KEGG   DRUG: Pacritinib
Entry
D11768                      Drug                                   
Name
Pacritinib (USAN/INN);
Vonjo (TN)
Product
VONJO (CTI BioPharma Corp.)
Formula
C28H32N4O3
Exact mass
472.2474
Mol weight
472.58
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
Anti-inflammatory
 DG01985  Disease modifying anti-rheumatic drug (DMARD)
  DG02020  JAK inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: L01EJ03
Product: D11768<US>
Efficacy
Antineoplastic, Tyrosine kinase inhibitor
  Disease
Myelofibrosis [DS:H01605]
Target
JAK2 [HSA:3717] [KO:K04447]
FLT3 (CD135) [HSA:2322] [KO:K05092]
  Pathway
hsa04151  PI3K-Akt signaling pathway
hsa04640  Hematopoietic cell lineage
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EJ Janus-associated kinase (JAK) inhibitors
     L01EJ03 Pacritinib
      D11768  Pacritinib (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Pacritinib
    D11768  Pacritinib (USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   D11768  Pacritinib
 Anti-inflammatory
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   DG02020  JAK inhibitor
    D11768  Pacritinib
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11768  Pacritinib
Drug classes [BR:br08332]
 Immunological agent
  DG02020  JAK inhibitor
   D11768  Pacritinib
 Antirheumatic agent
  DG01985  Disease modifying anti-rheumatic drug (DMARD)
   D11768  Pacritinib
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    FLT3 (CD135)
     D11768  Pacritinib (USAN/INN) <US>
  Non-receptor tyrosine kinases
   JAK family
    JAK2
     D11768  Pacritinib (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11768
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11768
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11768
Other DBs
CAS: 937272-79-2
PubChem: 405226634
ChEBI: 231350
PDB-CCD: 6T3[PDBj]
LinkDB
KCF data

ATOM        35
            1   C8y C    21.4200  -14.0000
            2   N4x N    21.4200  -15.4000
            3   C8y C    22.6100  -16.1000
            4   N5x N    23.8700  -15.4000
            5   C8x C    23.8700  -14.0000
            6   C8x C    22.6100  -13.3000
            7   N2x N    22.6100  -17.5000
            8   C8y C    20.2300  -13.3000
            9   C8x C    20.2300  -11.9000
            10  C8x C    18.9700  -11.2000
            11  C8x C    17.7800  -11.9000
            12  C8y C    17.7800  -13.3000
            13  C8x C    18.9700  -14.0000
            14  C1x C    16.5900  -14.0000
            15  O2x O    15.4000  -13.3000
            16  C1x C    14.2100  -14.0000
            17  C2x C    14.2100  -15.4000
            18  C2x C    15.4000  -16.1000
            19  C1x C    15.4000  -17.5000
            20  O2x O    16.5900  -18.2000
            21  C1x C    17.7800  -17.5000
            22  C8y C    18.9700  -18.2000
            23  C8y C    18.9700  -19.6000
            24  C8x C    20.1600  -20.3000
            25  C8x C    21.4200  -19.6000
            26  C8y C    21.4200  -18.2000
            27  C8x C    20.1600  -17.5000
            28  O2a O    17.7547  -20.2951
            29  C1b C    16.5663  -19.6023
            30  C1b C    15.3699  -20.2865
            31  N1y N    14.1887  -19.5981
            32  C1x C    14.2223  -18.2001
            33  C1x C    12.9055  -17.7373
            34  C1x C    12.0584  -18.8466
            35  C1x C    12.8517  -19.9950
BOND        39
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     3   7 2
            8     1   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   12  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   22  23 2
            24   23  24 1
            25   24  25 2
            26   25  26 1
            27   26  27 2
            28   22  27 1
            29   26   7 1
            30   22  21 1
            31   23  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   31  32 1
            36   32  33 1
            37   33  34 1
            38   34  35 1
            39   31  35 1

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