KEGG   DISEASE: 子宮頸癌
エントリ  
H00030                                                             
名称    
子宮頸癌
概要    
Cervical cancer is the second largest cause of cancer-related death in women worldwide, and it occurs following persistent infection, sometimes for decades, with a specific subset of human papillomavirus (HPV) types, particularly types 16, 18, 33 and 42. Experimental studies show that the E6 and E7 genes of these high risk HPVs are oncogenes that deregulate key cell cycle controls. The E6 and E7 oncoproteins bind respectively to the p53 and Retinoblastoma (Rb) tumor suppressor proteins, which are involved in the regulation of growth control. The abnormalities in other cellular genes found in cervical cancer, including mutations in ras family of genes, and amplification in EGFR and ERBB2, may also play an important role in carcinogenesis and the aggressiveness of cervical tumors, although to date the role of most of these genetic abnormalities does not appear to be as important as the role of HPV.
カテゴリ  
がん
階層分類  
ヒト疾患 [BR:jp08402]
 がん
  乳房および女性生殖器のがん
   H00030  子宮頸癌
ICD-11 による疾患分類 [BR:jp08403]
 02 腫瘍
  悪性腫瘍, ただしリンパ, 造血, 中枢神経系または関連組織の原発腫瘍を除く
   悪性腫瘍, 原発性と確定または推定されるもの, 明示された部位のもの, ただしリンパ, 造血, 中枢神経系, 関連組織を除く
    女性生殖器の悪性腫瘍
     2C77  子宮頚部の悪性腫瘍
      H00030  子宮頸癌
関連パスウェイ
hsa05200  Pathways in cancer
hsa05165  Human papillomavirus infection
hsa05203  Viral carcinogenesis
ネットワーク
nt06110  MAPK signaling (viruses and bacteria)
nt06114  PI3K signaling (viruses)
nt06116  NOTCH signaling (viruses)
nt06121  TLR signaling (viruses and bacteria)
nt06122  IFN signaling (viruses)
nt06123  TNF signaling (viruses and bacteria)
nt06129  MHC presentation (viruses)
nt06130  Cell cycle (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06140  Transcription (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06166  Human papillomavirus (HPV)
病因遺伝子 
K-ras (mutation) [HSA:3845] [KO:K07827]
H-ras (mutation) [HSA:3265] [KO:K02833]
EGFR (amplification) [HSA:1956] [KO:K04361]
ERBB2 (amplification) [HSA:2064] [KO:K05083]
p21 (overexpression) [HSA:1026] [KO:K06625]
CDK4 (overexpression) [HSA:1019] [KO:K02089]
Bcl-2 (overexpression) [HSA:596] [KO:K02161]
発癌物質  
Azathioprine [CPD:C06837]
Diethylstilboestrol [CPD:C07620]
Estrogens, nonsteroidal
Tobacco smoking and tobacco smoke
病原体   
Human papillomavirus type 16 [GN:T40087]
Human papillomavirus type 18 [GN:T40088]
治療薬   
シクロホスファミド水和物 [DR:D00287]
イホスファミド [DR:D00343]
フルオロウラシル [DR:D00584]
ドキシフルリジン [DR:D01309]
シタラビン [DR:D00168]
テガフール・ウラシル [DR:D02131]
マイトマイシンC [DR:D00208]
ブレオマイシン塩酸塩 [DR:D03229]
ピラルビシン塩酸塩 [DR:D08386]
エトポシド [DR:D00125]
パクリタキセル [DR:D00491]
ノギテカン塩酸塩 [DR:D02168]
イリノテカン塩酸塩水和物 [DR:D01061]
ベバシズマブ [DR:D06409]
シスプラチン [DR:D00275]
カルボプラチン [DR:D01363]
ネダプラチン [DR:D01416]
組換え沈降4価ヒトパピローマウイルス様粒子ワクチン [DR:D10192]
組換え沈降2価ヒトパピローマウイルス様粒子ワクチン [DR:D10212]
組換え沈降9価ヒトバピローマウイルス様粒子ワクチン [DR:D11863]
リンク   
ICD-11: 2C77
ICD-10: C53
MeSH: D002583
文献    
PMID:11486705 (gene, carcinogen)
  著者
Wolf JK, Ramirez PT.
  タイトル
The molecular biology of cervical cancer.
  雑誌
Cancer Invest 19:621-9 (2001)
DOI:10.1081/CNV-100104290
文献    
PMID:10471054 (gene, carcinogen)
  著者
Lazo PA.
  タイトル
The molecular genetics of cervical carcinoma.
  雑誌
Br J Cancer 80:2008-18 (1999)
DOI:10.1038/sj.bjc.6690635
文献    
PMID:16062089 (carcinogen)
  著者
Patel P, Moazzam N, Potti A, Mehdi SA.
  タイトル
Azathioprine induced hodgkin lymphoma: a case report and review of literature.
  雑誌
Am J Clin Oncol 28:427-8 (2005)
DOI:10.1097/01.coc.0000168670.28659.8d
文献    
PMID:15168959 (carcinogen)
  著者
Schrager S, Potter BE.
  タイトル
Diethylstilbestrol exposure.
  雑誌
Am Fam Physician 69:2395-400 (2004)
文献    
PMID:17390375 (carcinogen)
  著者
Troisi R, Hatch EE, Titus-Ernstoff L, Hyer M, Palmer JR, Robboy SJ, Strohsnitter WC, Kaufman R, Herbst AL, Hoover RN.
  タイトル
Cancer risk in women prenatally exposed to diethylstilbestrol.
  雑誌
Int J Cancer 121:356-60 (2007)
DOI:10.1002/ijc.22631
文献    
PMID:11281434 (carcinogen)
  著者
Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK.
  タイトル
Human papillomavirus infections: epidemiology, pathogenesis, and therapy.
  雑誌
J Cutan Med Surg 5:43-60 (2001)
DOI:10.1177/120347540100500110
文献    
PMID:15489140 (carcinogen)
  著者
Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA.
  タイトル
Environmental and chemical carcinogenesis.
  雑誌
Semin Cancer Biol 14:473-86 (2004)
DOI:10.1016/j.semcancer.2004.06.010
文献    
PMID:15552776 (carcinogen)
  著者
Sasco AJ, Secretan MB, Straif K.
  タイトル
Tobacco smoking and cancer: a brief review of recent epidemiological evidence.
  雑誌
Lung Cancer 45 Suppl 2:S3-9 (2004)
DOI:10.1016/j.lungcan.2004.07.998
文献    
PMID:12612656 (marker)
  著者
Baldwin P, Laskey R, Coleman N.
  タイトル
Translational approaches to improving cervical screening.
  雑誌
Nat Rev Cancer 3:217-26 (2003)
DOI:10.1038/nrc1010
文献    
PMID:12797857 (marker)
  著者
Garland SM.
  タイトル
Can we really beat cervical cancer?
  雑誌
Med J Aust 178:647-9 (2003)
DOI:10.5694/j.1326-5377.2003.tb05396.x
文献    
PMID:14739059 (marker)
  著者
Gadducci A, Cosio S, Carpi A, Nicolini A, Genazzani AR.
  タイトル
Serum tumor markers in the management of ovarian, endometrial and cervical cancer.
  雑誌
Biomed Pharmacother 58:24-38 (2004)
DOI:10.1016/j.biopha.2003.11.003
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