| Entry |
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| Symbol |
CYP2A6
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| Name |
cytochrome P450 family 2 subfamily A6 [EC:1.14.14.-]
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| Pathway |
| map00980 | Metabolism of xenobiotics by cytochrome P450 |
| map00982 | Drug metabolism - cytochrome P450 |
| map00983 | Drug metabolism - other enzymes |
| map05204 | Chemical carcinogenesis - DNA adducts |
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| Reaction |
| R07000 | naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing) |
| R07001 | naphthalene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing) |
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| Disease |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00830 Retinol metabolism
K17683 CYP2A6; cytochrome P450 family 2 subfamily A6
09110 Biosynthesis of other secondary metabolites
00232 Caffeine metabolism
K17683 CYP2A6; cytochrome P450 family 2 subfamily A6
09111 Xenobiotics biodegradation and metabolism
00980 Metabolism of xenobiotics by cytochrome P450
K17683 CYP2A6; cytochrome P450 family 2 subfamily A6
00982 Drug metabolism - cytochrome P450
K17683 CYP2A6; cytochrome P450 family 2 subfamily A6
00983 Drug metabolism - other enzymes
K17683 CYP2A6; cytochrome P450 family 2 subfamily A6
09160 Human Diseases
09161 Cancer: overview
05204 Chemical carcinogenesis - DNA adducts
K17683 CYP2A6; cytochrome P450 family 2 subfamily A6
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
K17683 CYP2A6; cytochrome P450 family 2 subfamily A6
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450
K17683 CYP2A6; cytochrome P450 family 2 subfamily A6
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
CYP2 family
K17683 CYP2A6; cytochrome P450 family 2 subfamily A6
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| Genes |
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| Reference |
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| Authors |
Miles JS, Bickmore W, Brook JD, McLaren AW, Meehan R, Wolf CR |
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| Title |
Close linkage of the human cytochrome P450IIA and P450IIB gene subfamilies: implications for the assignment of substrate specificity. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Fernandez-Salguero P, Hoffman SM, Cholerton S, Mohrenweiser H, Raunio H, Rautio A, Pelkonen O, Huang JD, Evans WE, Idle JR, et al. |
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| Title |
A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. |
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| Journal |
Am J Hum Genet 57:651-60 (1995) |
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| Sequence |
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| Reference |
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| Authors |
Xu C, Goodz S, Sellers EM, Tyndale RF |
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| Title |
CYP2A6 genetic variation and potential consequences. |
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| Journal |
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| LinkDB |
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