KEGG   ORTHOLOGY: K17719
Entry
K17719                      KO                                     
Symbol
CYP2C9
Name
cytochrome P450 family 2 subfamily C9 [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00830  Retinol metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map04726  Serotonergic synapse
map05204  Chemical carcinogenesis - DNA adducts
map05417  Lipid and atherosclerosis
Reaction
R07048  
R07050  
R07051  
R07055  
R07056  
R07079  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07080  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07081  benzpyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07085  benzo[a]pyrene-7,8-diol,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R07087  9-hydroxybenzo[a]pyrene,NADPH:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)
R08267  
R08275  
R08285  
R08324  
R08325  
R08326  
R08390  
R08392  
Disease
H01205  Coumarin resistance
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00591 Linoleic acid metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
   00982 Drug metabolism - cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.51  (S)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.52  (S)-limonene 7-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
    1.14.14.53  (R)-limonene 6-monooxygenase
     K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K17719  CYP2C9; cytochrome P450 family 2 subfamily C9
Other DBs
GO: 0018675 0018676 0052741
Genes
HSA: 1559(CYP2C9)
PTR: 100616515(CYP2C9)
PPS: 100996034(CYP2C9)
GGO: 101126456
PON: 100450749(CYP2C9)
PPYG: 129006530
NLE: 100591471
HMH: 116457268
SSYN: 129468897
MCC: 678686(CYP2C75) 678695(CYP2C9)
MCF: 102115450(CYP2C9) 102147103(CYP2C19)
MTHB: 126962028 126962032
MNI: 105479916 105479949
CSAB: 103216299(CYP2C19) 103216301(CYP2C9)
CATY: 105575618 105581138 105586929 105586938
PANU: 100997824 101012978
TGE: 112631549 112631550
MLEU: 105534699 105534700 105535382 105536626
RRO: 104665355 104666123
TFN: 117083900 117092015
PTEH: 111531037 111552212
CANG: 105501587 105504516 105504517
DORD: 106001520
NCAR: 124985776
TVP: 118828297 118828298 118828299 118828301 118828302
 » show all
Reference
PMID:3196692
  Authors
Ged C, Umbenhauer DR, Bellew TM, Bork RW, Srivastava PK, Shinriki N, Lloyd RS, Guengerich FP
  Title
Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.
  Journal
Biochemistry 27:6929-40 (1988)
DOI:10.1021/bi00418a039
  Sequence
[hsa:1559]
LinkDB

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