KEGG ORTHOLOGY: K01332

ORTHOLOGY: K01332

Entry

K01332                      KO

Symbol

Name

complement component 2 [EC:3.4.21.43]

Pathway

map04610

Complement and coagulation cascades

map04936

Alcoholic liver disease

map05133

Pertussis

map05150

Staphylococcus aureus infection

map05171

Coronavirus disease

map05322

Systemic lupus erythematosus

Disease

H00080

Systemic lupus erythematosus

H00102

Classic complement pathway component defects

H00821

Age-related macular degeneration

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K01332  C2; complement component 2
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease
    K01332  C2; complement component 2
  09171 Infectious disease: bacterial
   05133 Pertussis
    K01332  C2; complement component 2
   05150 Staphylococcus aureus infection
    K01332  C2; complement component 2
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K01332  C2; complement component 2
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K01332  C2; complement component 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01332  C2; complement component 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.43  classical-complement-pathway C3/C5 convertase
     K01332  C2; complement component 2
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K01332  C2; complement component 2

Genes

HSA:

717(C2)

PTR:	100608992(C2)

PPS:	103783827(C2)

GGO:	101145799(C2)

PON:	100173033(C2)

PPYG:

129039427(C2)

NLE:	100606928(C2)

HMH:	116460294(C2)

SSYN:

129473846(C2)

MCC:	106997899(C2)

MCF:	102137096(C2)

MTHB:

126953216

MNI:	105497597(C2)

CSAB:

103221735(C2)

CATY:

105583240(C2)

TGE:	112622243(C2)

MLEU:

105554204(C2)

RRO:	104678122(C2)

RBB:	108520263(C2)

TFN:	117086977(C2)

CANG:

105513812(C2)

CJC:	103792363(C2)

SBQ:	104650316(C2)

CIMI:

108299811(C2)

ANAN:

105706373(C2)

CSYR:

103271297(C2)

MMUR:

105858160(C2)

LCAT:

123631761(C2)

ERUF:

138395094(C2)

PCOQ:

105817869(C2)

OGA:	100948920(C2)

MMU:

12263(C2)

MCAL:

110312387(C2)

MPAH:

110336126(C2)

RNO:

24231(C2)

MCOC:

116075350(C2)

ASYL:

127670193(C2)

MUN:	110560138(C2)

CGE:	100759069(C2)

MAUA:

101829138(C2)

PLEU:

114705865(C2)

PMAV:

102911788(C2)

MORG:

121435235(C2)

MFOT:

126495378

AAMP:

119822469(C2)

CNL:	130890538(C2)

NGI:	103724419(C2)

HGL:	101723809(C2)

CPOC:

100716184(C2)

CCAN:

109689592(C2)

DORD:

105999865(C2)

DSP:	122111495(C2)

DMER:

138828219(C2)

PLOP:

125352766(C2)

NCAR:

124989526

MMMA:

107143589(C2)

ITI:	101978344(C2)

SCIL:

308648919(C2)

OCU:	100355553 127488893

OPI:	101519169(C2)

OCZ:	121161782(C2)

TUP:	102480144(C2)

GVR:	103592349(C2)

CFA:	474853(C2)

CLUD:

112641335(C2)

VVP:	112913623(C2)

VLG:	121500782(C2)

NPO:	129512458(C2)

AML:	100474163(C2)

UMR:	103682287(C2)

UAH:	113243740(C2)

UAR:	123790974(C2)

ELK:

111152312

LLV:

125101523

MPUF:

101692540(C2)

MNP:	132017821(C2)

MLK:	131834325(C2)

NVS:	122911435(C2)

MMAQ:

308344264(C2)

ORO:	101377842(C2)

EJU:	114222260(C2)

ZCA:	113927723(C2)

MLX:	118027318(C2)

MANO:

123837580(C2)

NSU:	110586911(C2)

LWW:	102735390(C2)

FCA:	101092434(C2)

PYU:	121022335(C2)

PCOO:

112853511(C2)

PBG:	122478264(C2)

PVIV:

125166103(C2)

LRUF:

124528942

LGF:	123608169(C2)

AJU:

106983482

PTG:	102969252(C2)

PPAD:

109260505(C2)

PUC:

125938420

PLEZ:

122219715(C2)

HHV:	120221933(C2)

CCRU:

144228993(C2)

BTA:	515440(C2)

BOM:	102269155(C2)

BIU:	109576932(C2)

BJV:	133236871(C2)

BBUB:

102406076(C2)

BKE:	129645756(C2)

BBIS:

104983805(C2)

CHX:	102176085(C2)

OAS:	101115321(C2)

OCAN:

138425928(C2)

BTAX:

128056021(C2)

CSUM:

138069480(C2)

ODA:	120870574(C2)

CCAD:

122429826(C2)

MREE:

136151285(C2)

OVR:	110139426(C2)

MBEZ:

129543572(C2)

SSC:	448981(C2)

CFR:	102518989(C2)

CDK:	105087440(C2)

VPC:	102528144(C2)

BACU:

103018276(C2)

BMUS:

118903150(C2)

LVE:	103071578(C2)

OOR:	101281566(C2)

LALB:

132527459(C2)

GMF:	115849418(C2)

DDP:	132432608(C2)

SCOO:

307193197(C2)

PCRS:

137231845(C2)

DLE:	111170704(C2)

PCAD:

102992128(C2)

PSIU:

116762860(C2)

PPHC:

136129365(C2)

NASI:

112395374(C2)

HAMP:

307058831(C2)

ECB:	100059162(C2)

EPZ:	103563291(C2)

EAI:	106831000(C2)

MYB:	102263362(C2)

MYD:	102766284(C2)

MMYO:

118679566(C2)

MLF:	102434614 102435622(C2)

MDT:	132237688(C2)

MYUM:

139012678(C2)

EFUS:

103300457(C2)

POTS:

308245764(C2)

MNA:	107538982(C2)

SHON:

118979560(C2)

AJM:	119053694(C2)

PDIC:

114494189(C2)

PHAS:

123810445(C2)

MMF:	118621434(C2)

PPAM:

129067328(C2)

RFQ:	117020467(C2)

RHII:

308493148(C2)

PALE:

102889530(C2)

PGIG:

120618902(C2)

PVP:	105305295(C2)

RAY:	107498438(C2)

MJV:	108393991(C2)

TOD:	119252228(C2)

SFUM:

130035723(C2)

SETR:

125996183(C2)

LAV:	100668309(C2)

TMU:

101350027

ETF:	101661223(C2)

MDO:	100025443(C2)

GAS:	123243666(C2)

SHR:	105750443(CFB)

AFZ:

127561087

PCW:	110199442(C2)

TVP:	118857287(C2)

PBRV:

138149989(C2)

MLAO:

141523469(C2)

OAA:

100089242

TACU:

119947147(C2)

GGA:	419574(C2)

PCOC:

116230112(C2)

MGP:

104914277

CJO:

107323905

TPAI:

128088525(C2)

LMUT:

125683968(C2)

NMEL:

110387356

ACHC:

115338421(CFB)

HLE:	104836577(C2)

CBOR:

142074111

MAME:

142403376 142403393

CRID:

134509430

ASN:	102381270(CFB)

AMJ:	102574290(C2)

CIZ:

142024699

CCAY:

125620990(C2)

LKP:	140904545(C2)

CPIC:

101947880

CABI:

116829917

EMQ:	137161155(C2)

ACS:	100556178(c2)

PVT:	110088698(C2)

SUND:

121922133(C2)

PBI:

103049015

PMUR:

107295035

CTIG:

120309290

NSS:	113424960(C2)

ZVI:

118080127

GJA:

107105482

EMC:	129329017(C2)

XLA:	734198(c2.L)

XTR:	100491079(c2)

NPR:

RTEM:

ACAT:

PADS:

BBUF:

BGAR:

DTC:

PWL:

MUO:	115458992 115466209(C2) 115474730

GSH:	117346944 117360271

DRE:

563828

DAES:

130241542(si:ch1073-280e3.1)

SRX:

107720441

SANH:

107662575

SGH:

107567682

CCAR:

109055343(si:ch1073-280e3.1)

CAUA:

113115417

CGIB:

127972321(si:ch1073-280e3.1)

PTET:

122358886(si:ch1073-280e3.1)

LROH:

127177064(si:ch1073-280e3.1)

GRF:

141284912

OMC:	131554417(si:ch1073-280e3.1)

PPRM:

120466881(si:ch1073-280e3.1)

RKG:	130097687(si:ch1073-280e3.1)

MAMB:

125248875(si:ch1073-280e3.1)

CIDE:

127495110(si:ch1073-280e3.1)

CERY:

137005460(si:ch1073-280e3.1)

MASI:

127422257

TROS:

130565167(si:ch1073-280e3.1)

TDW:	130429106(si:ch1073-280e3.1)

MANU:

129437571

PDAB:

135771470

IPU:	100862743(si:ch1073-280e3.1)

IFU:	128621027(si:ch1073-280e3.1)

PHYP:

113539139

SMEO:

124394571(si:ch1073-280e3.1)

TFD:	113643603(si:ch1073-280e3.1)

TVC:	132857764(si:ch1073-280e3.1)

CGAR:

128533205(si:ch1073-280e3.1)

NGRA:

132864701(si:ch1073-280e3.1)

TRN:	134334448(si:ch1073-280e3.1)

AMEX:

103046310(si:ch1073-280e3.1)

CMAO:

118802624(si:ch1073-280e3.1)

EEE:

113574701

CHAR:

105909325(si:ch1073-280e3.1)

SPIL:

134099044(si:ch1073-280e3.1)

ASAD:

121683211(si:ch1073-280e3.1)

TRU:

101064033

TFS:	130534764(si:ch1073-280e3.1)

TNG:	GSTEN00026804G001

NCC:

104962863

TBEN:

117469982(si:ch1073-280e3.1)

CGOB:

115017381

PGEO:

117457216

GACU:

117557378(si:ch1073-280e3.1)

EMAC:

134879681(si:ch1073-280e3.1)

ELY:

117259163

EFO:	125888711(si:ch1073-280e3.1)

PLEP:

121942912(si:ch1073-280e3.1)

SLUC:

116039027(si:ch1073-280e3.1)

ECRA:

117942570(si:ch1073-280e3.1)

ESP:

116685960

PFLV:

114549828

GAT:	120816446(si:ch1073-280e3.1)

PPUG:

119223014(si:ch1073-280e3.1)

AFB:	129102596(si:ch1073-280e3.1)

CLUM:

117741242(si:ch1073-280e3.1)

CANA:

137790838(si:ch1073-280e3.1) 137801432

CVE:	137869495(si:ch1073-280e3.1)

MSAM:

119882756(si:ch1073-280e3.1)

SCHU:

122878514(si:ch1073-280e3.1)

EARM:

139284967

CUD:	121523692(si:ch1073-280e3.1)

SPUL:

138604594

LMIX:

132979789 132979790

HTC:

141798046

ALAT:

119031698(si:ch1073-280e3.1)

ASTR:

137596481(si:ch1073-280e3.1)

PKLU:

139200319

LCO:

104930441

MZE:	101480328(si:ch1073-280e3.1)

ONL:

100697699

OAU:	116323697(si:ch1073-280e3.1)

OLA:

101167637

OML:	112136450(si:ch1073-280e3.1)

CSAI:

133441555(si:ch1073-280e3.1)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122832266(si:ch1073-280e3.1)

PPRL:

129358818(si:ch1073-280e3.1)

CVG:

107102499

CTUL:

119775419(si:ch1073-280e3.1)

GMU:	124883852(si:ch1073-280e3.1)

NFU:

107397014

KMR:	108244431(si:ch1073-280e3.1)

ALIM:

106530408

NWH:	119411148(si:ch1073-280e3.1)

LTU:

140314636

MCEP:

125013111

AOCE:

111574507(si:ch1073-280e3.1)

EJA:

138197059

BFRE:

138619046

LCF:	108890635(si:ch1073-280e3.1)

POV:

109642964

SSEN:

122772936(si:ch1073-280e3.1)

SSOE:

131462629(si:ch1073-280e3.1)

HHIP:

117772604(si:ch1073-280e3.1)

HSP:	118106051(si:ch1073-280e3.1)

PPLT:

128439653(si:ch1073-280e3.1)

SMAU:

118295617(si:ch1073-280e3.1)

XGL:	120792530(si:ch1073-280e3.1)

BPEC:

110162865

ENY:

140368549

BSPL:

114867603(si:ch1073-280e3.1)

SJO:	128360481(si:ch1073-280e3.1)

SSCO:

133980114(si:ch1073-280e3.1)

GMH:

115560915

SASA:

106580826

STRU:

115163141(si:ch1073-280e3.1)

OTW:	112265208(si:ch1073-280e3.1)

OMY:	100135805(si:ch1073-280e3.1)

OGO:	123992917(si:ch1073-280e3.1)

ONE:

115136963

OKI:

109905531

OKE:	118397273(si:ch1073-280e3.1)

OMM:	135552709(si:ch1073-280e3.1)

OCLA:

139385495

SALP:

111982534

SNH:	120018329(si:ch1073-280e3.1)

SFON:

129822010(si:ch1073-280e3.1)

CCLU:

121563694(si:ch1073-280e3.1)

ELS:

105011227

OEP:	134028612(si:ch1073-280e3.1)

SFM:

108928780

PKI:

111854971

AANG:

118209021(si:ch1073-280e3.1)

AROT:

135237026(si:ch1073-280e3.1)

CCOG:

133108346(si:ch1073-280e3.1)

LOC:	102694189 107079953

PSPA:

121304122

ARUT:

117433872(si:ch1073-280e3.1) 117971245

PSEX:

120539046(si:ch1073-280e3.1)

HAKA:

140719894

BFO:

118420754

CIN:	497243(bf-1) 619241(bf-2)

SPU:	587492 754422 756500 756883

LPIC:

129277947 129277948

LVG:	121428879 121429261

APLC:

110983861

ARUN:

117303019

AAMU:

139947954 139948327 139948328

SKO:

DALB:

CVS:

PTEP:

DPOL:

MAEA:

LJP:	135464968 135480710

LAK:	106177660 106178727

NVE:	5501707 5502106 5515331

EPA:	110235255 110235277 110235590 110242877 110244509 110253640

ATEN:

116298611 116308431 116308433

ADF:	107349284 107355215

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

111328750 111343603 111345231

RES:	135693962 135694096

CCLM:

134188511 134198295

» show all

Reference

PMID:14748705

Authors

Sim RB, Tsiftsoglou SA

Title

Proteases of the complement system.

Journal

Biochem Soc Trans 32:21-7 (2004)
DOI:10.1042/bst0320021

Reference

PMID:2949737

Authors

Bentley DR

Title

Primary structure of human complement component C2. Homology to two unrelated protein families.

Journal

Biochem J 239:339-45 (1986)
DOI:10.1042/bj2390339

Sequence

[hsa:717]

LinkDB

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