KEGG ORTHOLOGY: K01332

ORTHOLOGY: K01332

Entry

K01332                      KO

Symbol

Name

complement component 2 [EC:3.4.21.43]

Pathway

map04610

Complement and coagulation cascades

map04936

Alcoholic liver disease

map05133

Pertussis

map05150

Staphylococcus aureus infection

map05171

Coronavirus disease - COVID-19

map05322

Systemic lupus erythematosus

Disease

H00080

Systemic lupus erythematosus

H00102

Classic complement pathway component defects

H00821

Age-related macular degeneration

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K01332  C2; complement component 2
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K01332  C2; complement component 2
  09171 Infectious disease: bacterial
   05133 Pertussis
    K01332  C2; complement component 2
   05150 Staphylococcus aureus infection
    K01332  C2; complement component 2
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K01332  C2; complement component 2
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K01332  C2; complement component 2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01332  C2; complement component 2
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.43  classical-complement-pathway C3/C5 convertase
     K01332  C2; complement component 2
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S1: chymotrypsin family
   K01332  C2; complement component 2

Genes

HSA:

717(C2)

PTR:	100608992(C2)

PPS:	103783827(C2)

GGO:	101145799(C2)

PON:	100173033(C2)

PPYG:

129039427(C2)

NLE:	100606928(C2)

HMH:	116460294(C2)

SSYN:

129473846(C2)

MCC:	106997899(C2)

MCF:	102137096(C2)

MTHB:

126953216

MNI:	105497597(C2)

CSAB:

103221735(C2)

CATY:

105583240(C2)

TGE:	112622243(C2)

MLEU:

105554204(C2)

RRO:	104678122(C2)

RBB:	108520263(C2)

TFN:	117086977(C2)

CANG:

105513812(C2)

CJC:	103792363(C2)

SBQ:	104650316(C2)

CIMI:

108299811(C2)

ANAN:

105706373(C2)

CSYR:

103271297(C2)

MMUR:

105858160(C2)

LCAT:

123631761(C2)

ERUF:

138395094(C2)

PCOQ:

105817869(C2)

OGA:	100948920(C2)

MMU:

12263(C2)

MCAL:

110312387(C2)

MPAH:

110336126(C2)

RNO:

24231(C2)

MCOC:

116075350(C2)

ANU:	117724307(C2)

ASYL:

127670193(C2)

MUN:	110560138(C2)

CGE:	100759069(C2)

MAUA:

101829138(C2)

PLEU:

114705865(C2)

PMAV:

102911788(C2)

MORG:

121435235(C2)

MFOT:

126495378

AAMP:

119822469(C2)

NGI:	103724419(C2)

HGL:	101723809(C2)

CPOC:

100716184(C2)

CCAN:

109689592(C2)

DORD:

105999865(C2)

DSP:	122111495(C2)

DMER:

138828219(C2)

PLOP:

125352766(C2)

NCAR:

124989526

MMMA:

107143589(C2)

ITI:	101978344(C2)

OCU:	100355553 127488893

OPI:	101519169(C2)

OCZ:	121161782(C2)

TUP:	102480144(C2)

GVR:	103592349(C2)

CFA:	474853(C2)

CLUD:

112641335(C2)

VVP:	112913623(C2)

VLG:	121500782(C2)

NPO:	129512458(C2)

AML:	100474163(C2)

UMR:	103682287(C2)

UAH:	113243740(C2)

UAR:	123790974(C2)

ELK:

111152312

LLV:

125101523

MPUF:

101692540(C2)

MNP:	132017821(C2)

MLK:	131834325(C2)

NVS:	122911435(C2)

ORO:	101377842(C2)

EJU:	114222260(C2)

ZCA:	113927723(C2)

MLX:	118027318(C2)

NSU:	110586911(C2)

LWW:	102735390(C2)

FCA:	101092434(C2)

PYU:	121022335(C2)

PCOO:

112853511(C2)

PBG:	122478264(C2)

PVIV:

125166103(C2)

LRUF:

124528942

LGF:	123608169(C2)

AJU:

106983482

PTG:	102969252(C2)

PPAD:

109260505(C2)

PUC:

125938420

PLEZ:

122219715(C2)

HHV:	120221933(C2)

BTA:	515440(C2)

BOM:	102269155(C2)

BIU:	109576932(C2)

BBUB:

102406076(C2)

BBIS:

104983805(C2)

CHX:	102176085(C2)

OAS:	101115321(C2)

BTAX:

128056021(C2)

CSUM:

138069480(C2)

ODA:	120870574(C2)

CCAD:

122429826(C2)

MREE:

136151285(C2)

OVR:	110139426(C2)

MBEZ:

129543572(C2)

SSC:	448981(C2)

CFR:	102518989(C2)

CDK:	105087440(C2)

VPC:	102528144(C2)

BACU:

103018276(C2)

BMUS:

118903150(C2)

LVE:	103071578(C2)

OOR:	101281566(C2)

LALB:

132527459(C2)

GMF:	115849418(C2)

DDP:	132432608(C2)

DLE:	111170704(C2)

PCAD:

102992128(C2)

PSIU:

116762860(C2)

PPHC:

136129365(C2)

NASI:

112395374(C2)

ECB:	100059162(C2)

EPZ:	103563291(C2)

EAI:	106831000(C2)

MYB:	102263362(C2)

MYD:	102766284(C2)

MMYO:

118679566(C2)

MLF:	102434614 102435622(C2)

MDT:	132237688(C2)

MYUM:

139012678(C2)

EFUS:

103300457(C2)

MNA:	107538982(C2)

SHON:

118979560(C2)

AJM:	119053694(C2)

PDIC:

114494189(C2)

PHAS:

123810445(C2)

MMF:	118621434(C2)

PPAM:

129067328(C2)

RFQ:	117020467(C2)

PALE:

102889530(C2)

PGIG:

120618902(C2)

PVP:	105305295(C2)

RAY:	107498438(C2)

MJV:	108393991(C2)

TOD:	119252228(C2)

SFUM:

130035723(C2)

SETR:

125996183(C2)

LAV:	100668309(C2)

TMU:

101350027

ETF:	101661223(C2)

MDO:	100025443(C2)

GAS:	123243666(C2)

SHR:	105750443(CFB)

AFZ:

127561087

PCW:	110199442(C2)

TVP:	118857287(C2)

PBRV:

138149989(C2)

MLAO:

141523469(C2)

OAA:

100089242

TACU:

119947147(C2)

GGA:	419574(C2)

PCOC:

116230112(C2)

MGP:

104914277

CJO:

107323905

TPAI:

128088525(C2)

LMUT:

125683968(C2)

NMEL:

110387356

ACHC:

115338421(CFB)

HLE:	104836577(C2)

CBOR:

142074111

MAME:

142403376 142403393

CRID:

134509430

ASN:	102381270(CFB)

AMJ:	102574290(C2)

CIZ:

142024699

CCAY:

125620990(C2)

LKP:	140904545(C2)

CPIC:

101947880

CABI:

116829917

ACS:	100556178(c2)

PVT:	110088698(C2)

SUND:

121922133(C2)

PBI:

103049015

PMUR:

107295035

CTIG:

120309290

NSS:	113424960(C2)

ZVI:

118080127

GJA:

107105482

EMC:	129329017(C2)

XLA:	734198(c2.L)

XTR:	100491079(c2)

NPR:

RTEM:

ACAT:

PADS:

BBUF:

BGAR:

DTC:

PWL:

MUO:	115458992 115466209(C2) 115474730

GSH:	117346944 117360271

DRE:

SRX:

SANH:

SGH:

CCAR:

109055343(si:ch1073-280e3.1)

CAUA:

113115417

CGIB:

127972321(si:ch1073-280e3.1)

PTET:

122358886(si:ch1073-280e3.1)

LROH:

127177064(si:ch1073-280e3.1)

GRF:

141284912

OMC:	131554417(si:ch1073-280e3.1)

PPRM:

120466881(si:ch1073-280e3.1)

RKG:	130097687(si:ch1073-280e3.1)

MAMB:

125248875(si:ch1073-280e3.1)

CIDE:

127495110(si:ch1073-280e3.1)

CERY:

137005460(si:ch1073-280e3.1)

MASI:

127422257

TROS:

130565167(si:ch1073-280e3.1)

TDW:	130429106(si:ch1073-280e3.1)

MANU:

129437571

PDAB:

135771470

IPU:	100862743(si:ch1073-280e3.1)

IFU:	128621027(si:ch1073-280e3.1)

PHYP:

113539139

SMEO:

124394571(si:ch1073-280e3.1)

TFD:	113643603(si:ch1073-280e3.1)

TVC:	132857764(si:ch1073-280e3.1)

CGAR:

128533205(si:ch1073-280e3.1)

NGRA:

132864701(si:ch1073-280e3.1)

TRN:	134334448(si:ch1073-280e3.1)

AMEX:

103046310(si:ch1073-280e3.1)

CMAO:

118802624(si:ch1073-280e3.1)

EEE:

113574701

CHAR:

105909325(si:ch1073-280e3.1)

SPIL:

134099044(si:ch1073-280e3.1)

ASAD:

121683211(si:ch1073-280e3.1)

TRU:

101064033

TFS:	130534764(si:ch1073-280e3.1)

TNG:	GSTEN00026804G001

LCO:

104930441

NCC:

104962863

TBEN:

117469982(si:ch1073-280e3.1)

CGOB:

115017381

PGEO:

117457216

GACU:

117557378(si:ch1073-280e3.1)

EMAC:

134879681(si:ch1073-280e3.1)

ELY:	117259163(si:ch1073-280e3.1)

EFO:	125888711(si:ch1073-280e3.1)

PLEP:

121942912(si:ch1073-280e3.1)

SLUC:

116039027(si:ch1073-280e3.1)

ECRA:

117942570(si:ch1073-280e3.1)

ESP:

116685960

PFLV:

114549828

GAT:	120816446(si:ch1073-280e3.1)

PPUG:

119223014(si:ch1073-280e3.1)

AFB:	129102596(si:ch1073-280e3.1)

CLUM:

117741242(si:ch1073-280e3.1)

CANA:

137790838(si:ch1073-280e3.1) 137801432

CVE:	137869495(si:ch1073-280e3.1)

MSAM:

119882756(si:ch1073-280e3.1)

SCHU:

122878514(si:ch1073-280e3.1)

CUD:	121523692(si:ch1073-280e3.1)

SPUL:

138604594

LMIX:

132979789 132979790

HTC:

141798046

ALAT:

119031698(si:ch1073-280e3.1)

ASTR:

137596481(si:ch1073-280e3.1)

MZE:

101480328

ONL:

100697699

OAU:	116323697(si:ch1073-280e3.1)

OLA:

101167637

OML:	112136450(si:ch1073-280e3.1)

CSAI:

133441555(si:ch1073-280e3.1)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122832266(si:ch1073-280e3.1)

PPRL:

129358818(si:ch1073-280e3.1)

CVG:

107102499

CTUL:

119775419(si:ch1073-280e3.1)

GMU:	124883852(si:ch1073-280e3.1)

NFU:

107397014

KMR:	108244431(si:ch1073-280e3.1)

ALIM:

106530408

NWH:	119411148(si:ch1073-280e3.1)

AOCE:

111574507(si:ch1073-280e3.1)

EJA:

BFRE:

MCEP:

POV:

SSEN:

122772936(si:ch1073-280e3.1)

SSOE:

131462629(si:ch1073-280e3.1)

HHIP:

117772604(si:ch1073-280e3.1)

HSP:	118106051(si:ch1073-280e3.1)

PPLT:

128439653(si:ch1073-280e3.1)

SMAU:

118295617(si:ch1073-280e3.1)

LCF:	108890635(si:ch1073-280e3.1)

XGL:	120792530(si:ch1073-280e3.1)

BPEC:

110162865

ENY:

140368549

BSPL:

114867603(si:ch1073-280e3.1)

SJO:	128360481(si:ch1073-280e3.1)

SSCO:

133980114(si:ch1073-280e3.1)

GMH:

115560915

SASA:

106580826

STRU:

115163141

OTW:	112265208(si:ch1073-280e3.1)

OMY:	100135805(si:ch1073-280e3.1)

OGO:	123992917(si:ch1073-280e3.1)

ONE:

115136963

OKI:

109905531

OKE:	118397273(si:ch1073-280e3.1)

OMM:	135552709(si:ch1073-280e3.1)

OCLA:

139385495

SALP:

111982534

SNH:	120018329(si:ch1073-280e3.1)

SFON:

129822010(si:ch1073-280e3.1)

CCLU:

121563694(si:ch1073-280e3.1)

ELS:

105011227

OEP:	134028612(si:ch1073-280e3.1)

SFM:

108928780

PKI:

111854971

AANG:

118209021(si:ch1073-280e3.1)

AROT:

135237026(si:ch1073-280e3.1)

CCOG:

133108346(si:ch1073-280e3.1)

LOC:	102694189 107079953

PSPA:

121304122

ARUT:

117433872(si:ch1073-280e3.1) 117971245

PSEX:

120539046(si:ch1073-280e3.1)

HAKA:

140719894

BFO:

118420754

CIN:	497243(bf-1) 619241(bf-2)

SPU:	754422 756500 756883

LPIC:

129277947 129277948

LVG:	121428879 121429261

APLC:

110983861

ARUN:

117303019

AAMU:

139947954 139948327 139948328

SKO:

DALB:

CVS:

PTEP:

DPOL:

MAEA:

LJP:	135464968 135480710

LAK:	106177660 106178727

NVE:	5501707 5502106 5515331

EPA:	110235255 110235277 110235590 110242877 110244509 110253640

ATEN:

116298611 116308431 116308433

ADF:	107349284 107355215

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

111328750 111343603 111345231

RES:	135693962 135694096

» show all

Reference

PMID:14748705

Authors

Sim RB, Tsiftsoglou SA

Title

Proteases of the complement system.

Journal

Biochem Soc Trans 32:21-7 (2004)
DOI:10.1042/bst0320021

Reference

PMID:2949737

Authors

Bentley DR

Title

Primary structure of human complement component C2. Homology to two unrelated protein families.

Journal

Biochem J 239:339-45 (1986)
DOI:10.1042/bj2390339

Sequence

[hsa:717]

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