KEGG   ORTHOLOGY: K01332
Entry
K01332                      KO                                     
Symbol
C2
Name
complement component 2 [EC:3.4.21.43]
Pathway
map04610  Complement and coagulation cascades
map04936  Alcoholic liver disease
map05133  Pertussis
map05150  Staphylococcus aureus infection
map05171  Coronavirus disease - COVID-19
map05322  Systemic lupus erythematosus
Disease
H00080  Systemic lupus erythematosus
H00102  Classic complement pathway component defects
H00821  Age-related macular degeneration
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K01332  C2; complement component 2
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K01332  C2; complement component 2
  09171 Infectious disease: bacterial
   05133 Pertussis
    K01332  C2; complement component 2
   05150 Staphylococcus aureus infection
    K01332  C2; complement component 2
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K01332  C2; complement component 2
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K01332  C2; complement component 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01332  C2; complement component 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.43  classical-complement-pathway C3/C5 convertase
     K01332  C2; complement component 2
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K01332  C2; complement component 2
Genes
HSA: 717(C2)
PTR: 100608992(C2)
PPS: 103783827(C2)
GGO: 101145799(C2)
PON: 100173033(C2)
NLE: 100606928(C2)
MCC: 106997899(C2)
MCF: 102137096(C2)
CSAB: 103221735(C2)
CATY: 105583240(C2)
TGE: 112622243(C2)
RRO: 104678122(C2)
RBB: 108520263(C2)
TFN: 117086977(C2)
CJC: 103792363(C2)
SBQ: 104650316(C2)
CSYR: 103271297(C2)
MMUR: 105858160(C2)
OGA: 100948920(C2)
MMU: 12263(C2)
MCAL: 110312387(C2)
MPAH: 110336126(C2)
RNO: 24231(C2)
MCOC: 116075350(C2)
MUN: 110560138(C2)
CGE: 100759069(C2)
PLEU: 114705865(C2)
NGI: 103724419(C2)
HGL: 101723809(C2)
CPOC: 100716184(C2)
CCAN: 109689592(C2)
DORD: 105999865(C2)
DSP: 122111495(C2)
NCAR: 124989526
OCU: 100355553(C2)
OPI: 101519169(C2)
TUP: 102480144(C2)
CFA: 474853(C2)
VVP: 112913623(C2)
VLG: 121500782(C2)
AML: 100474163(C2)
UMR: 103682287(C2)
UAH: 113243740(C2)
UAR: 123790974(C2)
ELK: 111152312
LLV: 125101523
MPUF: 101692540(C2)
ORO: 101377842(C2)
EJU: 114222260(C2)
ZCA: 113927723(C2)
MLX: 118027318(C2)
FCA: 101092434(C2)
PYU: 121022335(C2)
PBG: 122478264(C2)
PTG: 102969252(C2)
PPAD: 109260505(C2)
AJU: 106983482(C2)
HHV: 120221933(C2)
BTA: 515440(C2)
BOM: 102269155(C2)
BIU: 109576932(C2)
BBUB: 102406076(C2)
CHX: 102176085(C2)
OAS: 101115321(C2)
ODA: 120870574(C2)
CCAD: 122429826(C2)
SSC: 448981(C2)
CFR: 102518989(C2)
CDK: 105087440(C2)
VPC: 102528144(C2)
BACU: 103018276(C2)
LVE: 103071578(C2)
OOR: 101281566(C2)
DLE: 111170704(C2)
PCAD: 102992128(C2)
PSIU: 116762860(C2)
ECB: 100059162(C2)
EPZ: 103563291(C2)
EAI: 106831000(C2)
MYB: 102263362(C2)
MYD: 102766284(C2)
MMYO: 118679566(C2)
MNA: 107538982(C2)
SHON: 118979560(C2)
AJM: 119053694(C2)
PDIC: 114494189(C2)
PHAS: 123810445(C2)
MMF: 118621434(C2)
RFQ: 117020467(C2)
PALE: 102889530(C2)
PGIG: 120618902(C2)
PVP: 105305295(C2)
RAY: 107498438(C2)
MJV: 108393991(C2)
TOD: 119252228(C2)
LAV: 100668309(C2)
TMU: 101350027
MDO: 100025443(C2)
GAS: 123243666(C2)
SHR: 105750443(CFB)
PCW: 110199442(C2)
OAA: 100089242
GGA: 419574(C2)
PCOC: 116230112(C2)
MGP: 104914277
CJO: 107323905
NMEL: 110387356
ACHC: 115338421(CFB)
ASN: 102381270(CFB)
AMJ: 102574290(C2)
CPIC: 101947880
CABI: 116829917
ACS: 100556178(c2)
PVT: 110088698(C2)
SUND: 121922133(C2)
PBI: 103049015
PMUR: 107295035
ZVI: 118080127
GJA: 107105482
XLA: 734198(c2.L)
XTR: 100491079(c2)
NPR: 108786508
RTEM: 120913253
BBUF: 120977489
BGAR: 122946772
DRE: 563828(si:ch1073-280e3.1)
SRX: 107720441
SANH: 107662575
SGH: 107567682
CCAR: 109055343
CAUA: 113115417
PPRM: 120466881(si:ch1073-280e3.1)
MAMB: 125248875(si:ch1073-280e3.1)
IPU: 100862743(si:ch1073-280e3.1)
PHYP: 113539139
SMEO: 124394571(si:ch1073-280e3.1)
TFD: 113643603(si:ch1073-280e3.1)
AMEX: 103046310
EEE: 113574701
TRU: 101064033
LCO: 104930441
NCC: 104962863
CGOB: 115017381
ELY: 117259163(si:ch1073-280e3.1)
PLEP: 121942912(si:ch1073-280e3.1)
SLUC: 116039027(si:ch1073-280e3.1)
ECRA: 117942570(si:ch1073-280e3.1)
PFLV: 114549828
GAT: 120816446(si:ch1073-280e3.1)
PPUG: 119223014(si:ch1073-280e3.1)
MSAM: 119882756(si:ch1073-280e3.1)
CUD: 121523692(si:ch1073-280e3.1)
ALAT: 119031698(si:ch1073-280e3.1)
MZE: 101480328
ONL: 100697699
OAU: 116323697(si:ch1073-280e3.1)
OLA: 101167637
OML: 112136450(si:ch1073-280e3.1)
XMA: 102229083
XCO: 114161640
XHE: 116737354
PRET: 103474842
PFOR: 103154630
PLAI: 106965101
PMEI: 106914174
GAF: 122832266(si:ch1073-280e3.1)
CVG: 107102499
CTUL: 119775419(si:ch1073-280e3.1)
GMU: 124883852(si:ch1073-280e3.1)
NFU: 107397014
KMR: 108244431(si:ch1073-280e3.1)
ALIM: 106530408
NWH: 119411148(si:ch1073-280e3.1)
AOCE: 111574507
POV: 109642964
SSEN: 122772936(si:ch1073-280e3.1)
HHIP: 117772604(si:ch1073-280e3.1)
LCF: 108890635
XGL: 120792530(si:ch1073-280e3.1)
BPEC: 110162865
BSPL: 114867603(si:ch1073-280e3.1)
SASA: 106580826
OTW: 112265208(si:ch1073-280e3.1)
OMY: 100135805(si:ch1073-280e3.1)
OGO: 123992917(si:ch1073-280e3.1)
ONE: 115136963
SALP: 111982534
SNH: 120018329(si:ch1073-280e3.1)
ELS: 105011227
SFM: 108928780
PKI: 111854971
AANG: 118209021(si:ch1073-280e3.1)
PSPA: 121304122
ARUT: 117433872(si:ch1073-280e3.1) 117971245
RTP: 109921429
BFO: 118420754
CIN: 497243(bf-1) 619241(bf-2)
APLC: 110983861
SKO: 100368814
PTEP: 107450490
 » show all
Reference
  Authors
Sim RB, Tsiftsoglou SA
  Title
Proteases of the complement system.
  Journal
Biochem Soc Trans 32:21-7 (2004)
DOI:10.1042/bst0320021
Reference
PMID:2949737
  Authors
Bentley DR
  Title
Primary structure of human complement component C2. Homology to two unrelated protein families.
  Journal
Biochem J 239:339-45 (1986)
DOI:10.1042/bj2390339
  Sequence
[hsa:717]
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