Entry
Name
lipoate---protein ligase;
lplA (gene name);
lplJ (gene name);
lipoate protein ligase;
lipoate-protein ligase A;
LPL;
LPL-B
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
BRITE hierarchy
Sysname
[lipoyl-carrier protein]-L-lysine:lipoate ligase (AMP-forming)
Reaction(IUBMB)
ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction) [RN:
R11143 ];
(1a) ATP + (R)-lipoate = lipoyl-AMP + diphosphate [RN:
R07770 ];
(1b) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP [RN:
R07771 ]
Reaction(KEGG)
Substrate
Product
[lipoyl-carrier protein]-N6-(lipoyl)lysine [CPD:
C16237 ];
AMP [CPD:
C00020 ];
diphosphate [CPD:
C00013 ];
lipoyl-AMP [CPD:
C16238 ]
Comment
Requires Mg2+. This enzyme participates in lipoate salvage, and is responsible for lipoylation in the presence of exogenous lipoic acid [7]. The enzyme attaches lipoic acid to the lipoyl domains of certain key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E2 domain), 2-oxoglutarate dehydrogenase (E2 domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein) [6]. Lipoylation is essential for the function of these enzymes. The enzyme can also use octanoate instead of lipoate.
History
EC 6.3.1.20 created 2006 as EC 2.7.7.63, transferred 2016 to EC 6.3.1.20
Pathway
Orthology
K03800 lipoate---protein ligase
Genes
NTE : NEUTE1DRAFT65646(NEUTE1DRAFT_65646)
ALUC : AKAW2_31034A(AIM22)
ABP : AGABI1DRAFT72757(AGABI1DRAFT_72757)
ABV : AGABI2DRAFT211723(AGABI2DRAFT_211723)
PCB : PCHAS_141490(PC000765.00.0)
BBO : BBOV_I003930(19.m02378)
TET : TTHERM_00535630 TTHERM_01075670
SMIN : v1.2.016157.t1(symbB.v1.2.016157.t1)
TCR : 509611.100 510857.50
ECW : EcE24377A_4985(lplA)
EDJ : ECDH1ME8569_4242(lplA)
ECOI : ECOPMV1_04846(lplA)
SEM : STMDT12_C47010(lplA)
SETC : CFSAN001921_17545(lplA)
SEEN : SE451236_05900(lplA)
SENH : CFSAN002069_09320(lplA)
SEEH : SEEH1578_08920(lplA)
SENJ : CFSAN001992_11155(lplA)
SEEC : CFSAN002050_06365(lplA)
SEEB : SEEB0189_019500(lplA)
SENC : SEET0819_06790(lplA)
RTG : NCTC13098_06352(lplA_2)
REE : electrica_04337(lplA)
CLAP : NCTC11466_03927(lplA)
KIE : NCTC12125_03070(lplA)
BAGE : BADSM9389_06010(lplA)
METY : MRY16398_48430(lplA)
AHN : NCTC12129_00708(lplA_2)
PSHI : SAMEA2665130_1872(lplA)
SMW : SMWW4_v1c21910(lplA)
SERS : SERRSCBI_10275(lplA)
SERA : Ser39006_011950(lplA)
SFJ : SAMEA4384070_2220(lplA)
SOF : NCTC11214_04672(lplA)
PLF : PANA5342_p10262(lplA)
PVA : Pvag_pPag30250(lplA)
PHEI : NCTC12003_02326(lplA)
PRJ : NCTC6933_01649(lplA)
LRI : NCTC12151_01719(lplA)
PPR : PBPRB1373 PBPRB1808(LPLA)
PSYC : DABAL43B_0236(lplA)
HHC : M911_11190 M911_12655 M911_13110
EBS : ECTOBSL9_0277 ECTOBSL9_0597 ECTOBSL9_2126
TNI : TVNIR_1885(lplJ_[H])
APRS : BI364_05090 BI364_13765
GAI : IMCC3135_18605(lplA)
AEL : NCTC12917_02942(lplA)
CHJ : NCTC10426_01432(lplJ)
ACII : C4901_01305 C4901_03775 C4901_12930 C4901_15015
ATY : A9R16_001130 A9R16_004040 A9R16_012695
CDIZ : CEDIAZO_03289(lplA)
LMIR : NCTC12852_00971 NCTC12852_01467(lplA)
BHZ : ACR54_00419(lipM) ACR54_02585(lplA)
BTRM : SAMEA390648703375(lplA)
AXX : ERS451415_02527(lplA)
ADN : Alide_0400 Alide_2337
ADK : Alide2_0345 Alide2_2531
OTO : ADJ79_00170 ADJ79_12665
SDR : SCD_n00426 SCD_n00803
DEK : DSLASN_13920 DSLASN_13960
DTI : Desti_0239 Desti_0742
NEN : NCHU2750_46950(lplA)
AFE : Lferr_2173 Lferr_2343
AFI : Acife_2466 Acife_3277
AFJ : AFERRID_05050 AFERRID_06760
BAZ : BAMTA208_04810(yhfJ)
BFD : NCTC4823_02826(lplJ)
OCN : CUC15_07350 CUC15_13780
LAO : AOX59_08700 AOX59_12450
BLEN : NCTC4824_03014(lplJ)
SAH : SaurJH1_0386 SaurJH1_1108
SAJ : SaurJH9_0376 SaurJH9_1086
SAX : USA300HOU_0348(lplA1)
SAA : SAUSA300_0328 SAUSA300_0930
SAO : SAOUHSC_00308 SAOUHSC_00963
SUU : M013TW_0308 M013TW_0956
SUV : SAVC_01385 SAVC_04300
SUE : SAOV_0353 SAOV_0973c
SUJ : SAA6159_00303(lplA1) SAA6159_00883
SUK : SAA6008_00304(lplA1) SAA6008_00982
SUT : SAT0131_00332 SAT0131_01062
SUQ : HMPREF0772_10168 HMPREF0772_12207
SUZ : MS7_0317 MS7_0985(lplJ)
SUD : ST398NM01_0408 ST398NM01_1025
SUX : SAEMRSA15_02830 SAEMRSA15_08570
SUW : SATW20_03950 SATW20_10240
SUF : SARLGA251_02890 SARLGA251_09420
SAUA : SAAG_00815 SAAG_02136
SAUE : RSAU_000273 RSAU_000914
SAUN : SAKOR_00322 SAKOR_00946
SAUS : SA40_0285 SA40_0897
SAUU : SA957_0300 SA957_0912
SAUG : SA268_0297 SA268_0914
SAUZ : SAZ172_0328 SAZ172_0968
SAUT : SAI1T1_2002520 SAI1T1_2007290
SAUJ : SAI2T2_1002520 SAI2T2_1007310
SAUK : SAI3T3_1002520 SAI3T3_1007300
SAUQ : SAI4T8_1002520 SAI4T8_1007290
SAUV : SAI7S6_1002520 SAI7S6_1007300
SAUW : SAI5S5_1002510 SAI5S5_1007260
SAUX : SAI6T6_1002520 SAI6T6_1007270
SAUY : SAI8T7_1002520 SAI8T7_1007300
SAUF : X998_0384 X998_1027
SUY : SA2981_0326 SA2981_0981
SAUB : C248_0381 C248_1052
SAUM : BN843_3330 BN843_9340
SAUC : CA347_341 CA347_946(lplJ)
SAUR : SABB_00995 SABB_01521
SAUI : AZ30_01680 AZ30_04895
SAUD : CH52_00740 CH52_04090
SAMS : NI36_01550 NI36_04900
SUH : SAMSHR1132_03010 SAMSHR1132_08740
SHH : ShL2_00179(lplA1) ShL2_01793
SLG : SLGD_00254 SLGD_01841
SLN : SLUG_02530 SLUG_18350
SDP : NCTC12225_02014(lplJ)
SXY : BE24_02485 BE24_11115
SXL : SXYLSMQ121_0195 SXYLSMQ121_1757
SXO : SXYL_00194 SXYL_01905
SEQO : SE1039_07820 SE1039_23880
SCOH : BZ166_00710 BZ166_05505
SNL : BJD96_01270 BJD96_09750
SPIC : SAMEA4384060_1920(lplJ)
SSH : NCTC13712_00275(lplJ_1) NCTC13712_00973(lplJ_2)
SSIM : SAMEA4384339_0276(lplJ_1) SAMEA4384339_0878(lplJ_2)
SAUL : I6G39_01020 I6G39_08125
SSTE : SAMEA4384403_1827(lplJ)
MLEN : H3V22_08215 H3V22_13450
JEA : JEM45_00415 JEM45_10820
NAMP : KPF49_05510 KPF49_06770
LMN : LM5578_0844 LM5578_1012
LMY : LM5923_0799 LM5923_0966
LMT : LMRG_00452 LMRG_02030
LMOC : LMOSLCC5850_0764 LMOSLCC5850_0933
LMOE : BN418_0882 BN418_1132 BN418_1133
LMOB : BN419_0889 BN419_1134 BN419_1135
LMOD : LMON_0768 LMON_0937
LMOW : AX10_12360 AX10_13215
LMOQ : LM6179_1076(lplJ) LM6179_1246(lplJ)
LMR : LMR479A_0783(lplJ) LMR479A_0953(lplJ)
LMOM : IJ09_05645 IJ09_06505
LMF : LMOf2365_0788 LMOf2365_0952
LMC : Lm4b_00780 Lm4b_00950
LMOG : BN389_07970(lplJ) BN389_09610(lplJ_2)
LMOL : LMOL312_0764 LMOL312_0932
LMOJ : LM220_04131 LM220_10872
LMOZ : LM1816_00720 LM1816_12992
LMOX : AX24_01140 AX24_02030
LMH : LMHCC_1691 LMHCC_1864
LMQ : LMM7_0795(lplA) LMM7_0967(lplA)
LML : lmo4a_0776 lmo4a_0946
LMG : LMKG_01113 LMKG_02361
LMJ : LMOG_00798 LMOG_01970
LMW : LMOSLCC2755_0765 LMOSLCC2755_0932
LMX : LMOSLCC2372_0774 LMOSLCC2372_0944
LMZ : LMOSLCC2482_0808 LMOSLCC2482_0976
LMON : LMOSLCC2376_0731 LMOSLCC2376_0902
LMOS : LMOSLCC7179_0741 LMOSLCC7179_0911
LMOO : LMOSLCC2378_0784 LMOSLCC2378_0948
LMOY : LMOSLCC2479_0772 LMOSLCC2479_0943
LMOT : LMOSLCC2540_0764 LMOSLCC2540_0930
LMOA : LMOATCC19117_0788 LMOATCC19117_0953
LMOK : CQ02_04030 CQ02_04870
LMV : Y193_11095 Y193_11970
LII : JL52_03800 JL52_04680
LIW : AX25_03870 AX25_04760
LIA : JL58_03880 JL58_04885
LIO : JL53_04420 JL53_05365
LWI : UE46_05775 UE46_06090
LGZ : NCTC10812_01951(lplJ_1) NCTC10812_02122(lplJ_2)
LMAR : LAX80_003480(lplA2) LAX80_004270(lplA1)
GMO : NCTC11323_01396(lplJ)
GHA : NCTC10459_00022(lplJ_1) NCTC10459_00024(lplJ_2) NCTC10459_01419(lplJ_3)
PLUT : EI981_12340 EI981_21625
COHN : KCTCHS21_48530(lplA)
SPY : SPy_1033 SPy_1214(lplA)
SPZ : M5005_Spy0758(lplB) M5005_Spy0928(lplA)
SPYM : M1GAS476_0820(lplB) M1GAS476_0986(lplA)
SPYA : A20_0799 A20_0964c(lplA)
SPM : spyM18_1015 spyM18_1166(lplA)
SPG : SpyM3_0666 SpyM3_0854(lplA)
SPH : MGAS10270_Spy0875(lplB) MGAS10270_Spy1042(lplA)
SPI : MGAS10750_Spy0910(lplB) MGAS10750_Spy1077(lplA)
SPJ : MGAS2096_Spy0832(lplB) MGAS2096_Spy0987(lplA)
SPK : MGAS9429_Spy0872(lplB) MGAS9429_Spy1031(lplA)
SPF : SpyM50870(lplA) SpyM51001
SPA : M6_Spy0783 M6_Spy0917
SPB : M28_Spy0737(lplB) M28_Spy0900(lplA)
STG : MGAS15252_0785(lplA.1) MGAS15252_0925(lplA.2)
STX : MGAS1882_0781(lplA) MGAS1882_0920(lplA.2)
SOZ : Spy49_0812 Spy49_0960c(lplA)
STZ : SPYALAB49_000783 SPYALAB49_000919
SPYH : L897_03950 L897_04590
SPYO : STAB901_04365 STAB901_05230
SAG : SAG0882(lplA-1) SAG1056(lplA-2)
SAK : SAK_1005(lplA) SAK_1145(lplA)
SGC : A964_0885(lplA) A964_1031(lplA)
SAGS : SaSA20_0757 SaSA20_0880(lplA)
SAGL : GBS222_0753(lplA) GBS222_0882(lplA)
SAGI : MSA_10300 MSA_11780
SAGR : SAIL_10260 SAIL_11700
SAGP : V193_04195 V193_04840
SAGC : DN94_04195 DN94_04840
SAGT : GBSCOH1_0809 GBSCOH1_0965
SAGE : EN72_05145 EN72_05905
SAGG : EN73_04845 EN73_05470
SAGN : W903_0973 W903_1144
SMC : SmuNN2025_0119(lplA)
SRP : SSUST1_0307 SSUST1_1720
SSUT : TL13_0336 TL13_1624
SSUI : T15_0306(lplA) T15_1891
SDS : SDEG_1034(lplA) SDEG_1243(lplB)
SDG : SDE12394_05790 SDE12394_06505
SDA : GGS_0993(lplA) GGS_1127(lplB)
SDC : SDSE_1066(lplA) SDSE_1219(lplB)
SDQ : SDSE167_1138(lplA) SDSE167_1362(lplB)
SGG : SGGBAA2069_c08560(lplB)
SRQ : SR187_1585 SR187_8240
SVB : NCTC12167_00978(lplA)
SMEN : SAMEA4412692_1385(lplJ)
SFER : NCTC12278_00183(lplJ)
SCAI : NCTC12191_01455(lplB) NCTC12191_01694(lplA)
SPSU : NCTC13786_00407(lplJ)
SPOC : NCTC10925_00773(lplJ)
SAUP : NCTC3168_01714(lplA)
SURN : NCTC13766_01203(lplA_1) NCTC13766_01354(lplA_2)
SVF : NCTC3166_01033(lplA)
LPL : lp_2643(lplA1) lp_2734(lplA2)
LPJ : JDM1_2119(lplA1) JDM1_2191(lplA2)
LPT : zj316_2543(lplA1) zj316_2623(lplA2)
LPS : LPST_C2172(lplA1) LPST_C2244(lplA2)
LPR : LBP_cg2168 LBP_cg2237
LPB : SH83_11160 SH83_11500
LPX : ASU28_11180 ASU28_11500
LPG : BB562_04110 BB562_04485
LARG : LPA65_11475 LPA65_11810
LFE : LAF_0831 LAF_1136 LAF_1710
LFR : LC40_0546 LC40_0739 LC40_1086
LFF : LBFF_0874 LBFF_1253 LBFF_1894
LOR : AYI71_02970 AYI71_10070 AYI71_13240 AYI71_14710
LVA : LV515_04160 LV515_04430 LV515_04825 LV515_08575
LFN : LF145_00730 LF145_01625 LF145_04105 LF145_07970
LPON : LP475_04590 LP475_05300 LP475_07890
LGAS : LG045_02460 LG045_03440 LG045_08850
LPAS : KZE55_05360 KZE55_08980
LNG : BSQ50_00265 BSQ50_10535
LHW : BSQ49_00285 BSQ49_10020
LMAL : LM596_00465 LM596_10325
LBH : Lbuc_0419 Lbuc_1860 Lbuc_2068 Lbuc_2129
LBN : LBUCD034_0333(lpla1) LBUCD034_0460 LBUCD034_0462 LBUCD034_1947(lpla3) LBUCD034_2163 LBUCD034_2228
LPAR : FAM21731_00542 FAM21731_00544 FAM21731_00687 FAM21731_00959 FAM21731_01268 FAM21731_01343 FAM21731_01568
LCU : PL11_004815 PL11_005015
LKF : DNL43_03195 DNL43_03730 DNL43_06680 DNL43_06970
LHIL : G8J22_00214(lplJ_1) G8J22_00225 G8J22_00387(lplJ_2) G8J22_02351(lplJ_3) G8J22_02507(lplJ_4)
LBR : LVIS_0180 LVIS_1647 LVIS_1950
LBK : LVISKB_0181 LVISKB_1588 LVISKB_1931
LKO : ABN16_06510 ABN16_08430 ABN16_10090
LZY : LZ3411_1962 LZ3411_2222
LSUA : H3M12_00655 H3M12_01890
LACA : LAC1533_2239 LAC1533_2373
LHO : LOOC260_101870(lplA) LOOC260_106070 LOOC260_119990
LPD : AYR62_00340 AYR62_10025 AYR62_12380
LMAE : FGL90_03075 FGL90_05225 FGL90_05230
LROS : LROSL1_0457 LROSL1_2238
LGN : ABM34_02760 ABM34_02765 ABM34_07170
LFM : LF20184_00750 LF20184_06660
LFT : FG051_00375 FG051_06290
CPAB : G6534_05185 G6534_11030
LAH : LA20533_03820 LA20533_08075
LBM : DS830_05750 DS830_08020
OSI : DLJ48_02000 DLJ48_04675
EFA : EF0650(lplA-1) EF2741(lplA-2)
EFI : OG1RF_10381(lplA) OG1RF_12105(lplA2)
EFD : EFD32_0463 EFD32_2358
EFS : EFS1_0496(lplA-1) EFS1_2206(lplA-2)
EFN : DENG_00677(lplA) DENG_02684(lplA)
EFU : HMPREF0351_10758(lplA)
ECAS : ECBG_00737 ECBG_02068
EGA : AL523_11495 AL523_14805
ESS : ATZ33_09035 ATZ33_10985
ECEC : NCTC12421_00534(lplJ_1) NCTC12421_00991(lplJ_2) NCTC12421_01790(lplJ_3)
EIE : ENLAB_03490(lplA_1) ENLAB_30480(lplA_3)
THL : TEH_06580(lplA) TEH_07190(lplA)
TEY : GLW17_09525 GLW17_09840
TOO : C7K38_06635 C7K38_06785 C7K38_07095
TKR : C7K43_00250 C7K43_11855
VCP : H9L18_12860 H9L18_12975
VHY : G7082_08090 G7082_08210
AUR : HMPREF9243_0579 HMPREF9243_1716 HMPREF9243_1775
AUN : AWM73_01125 AWM73_01410 AWM73_06670
AUI : APT62_01995 APT62_06930
ASAN : AWM72_06920 AWM72_07280
ACG : AWM71_02320 AWM71_06380
AVS : AWM76_03260 AWM76_08445
AUH : AWM75_01090 AWM75_06345 AWM75_07990
ADC : FOC79_00195 FOC79_04665
ABAE : CL176_01105 CL176_09085
JEH : EJN90_07090 EJN90_10550
DPM : FNV33_01355 FNV33_03095 FNV33_07215
GAD : K8O88_06755 K8O88_07295
CBO : CBO0701(lplA1) CBO1635(lplA2)
CBJ : H04402_00776 H04402_01707
CLJ : CLJU_c09210 CLJU_c33220(lplA)
CAH : CAETHG_1221 CAETHG_3015
CLD : CLSPO_c07320(lplJ1) CLSPO_c13660(lplJ2) CLSPO_c16940(lplJ3)
CCK : Ccar_03135 Ccar_23445
CDRK : B9W14_01840 B9W14_08210
CLOS : DMR38_04330 DMR38_16615
FPLA : A4U99_06090 A4U99_06860 A4U99_13565
PFAA : MM59RIKEN_04740 MM59RIKEN_15320 MM59RIKEN_27880(lplA1)
VFA : MM35RIKEN_16160(lplA1) MM35RIKEN_23070 MM35RIKEN_23100(lplA)
CSCI : HDCHBGLK_03370(lplA)
CSH : Closa_1167 Closa_1530
CPRO : CPRO_09560(lplJ_1) CPRO_13610(lplJ_2)
CBOL : CGC65_05085 CGC65_29375
CDF : CD630_00460 CD630_16540(lplA)
PDC : CDIF630_00108 CDIF630_01832(lplA)
CDC : CD196_0047 CD196_1577(lplA)
CDL : CDR20291_0035 CDR20291_1552(lplA)
PDF : CD630DERM_00460 CD630DERM_16540(lplA)
EAC : EAL2_808p06490(lplA)
CST : CLOST_2072(yhfJ) CLOST_2087(yhfJ)
TEM : JW646_00935 JW646_02870