KEGG ORTHOLOGY: K03904

ORTHOLOGY: K03904

Entry

K03904                      KO

Symbol

FGB

Name

fibrinogen beta chain

Pathway

map04610

Complement and coagulation cascades

map04611

Platelet activation

map04613

Neutrophil extracellular trap formation

map05171

Coronavirus disease - COVID-19

Disease

H00222

Congenital fibrinogen deficiency

H00223

Inherited thrombophilia

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03904  FGB; fibrinogen beta chain
   04611 Platelet activation
    K03904  FGB; fibrinogen beta chain
   04613 Neutrophil extracellular trap formation
    K03904  FGB; fibrinogen beta chain
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K03904  FGB; fibrinogen beta chain
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K03904  FGB; fibrinogen beta chain
   00536 Glycosaminoglycan binding proteins
    K03904  FGB; fibrinogen beta chain
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of hepatic cells
   K03904  FGB; fibrinogen beta chain
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Extracellular matrix molecules
   K03904  FGB; fibrinogen beta chain
Hyaluronan
  Extracellular matrix or blood plasma proteins
   K03904  FGB; fibrinogen beta chain

Genes

HSA:

2244(FGB)

PTR:	461558(FGB)

PPS:	100992445(FGB)

GGO:	101133258(FGB)

PON:	100173861(FGB)

PPYG:

129035616(FGB)

NLE:	100606953(FGB)

HMH:	116465465(FGB)

SSYN:

129481160(FGB)

MCC:	698487(FGB)

MCF:	102118738(FGB)

MTHB:

126955429

MNI:	105463510(FGB)

CSAB:

103236419(FGB)

CATY:

105580679(FGB)

PANU:

101017243(FGB)

TGE:	112624900(FGB)

MLEU:

105532319(FGB)

RRO:	104657127(FGB)

RBB:	108529036(FGB)

TFN:	117086050(FGB)

PTEH:

111553252(FGB)

CANG:

105524465(FGB)

CJC:	100392644(FGB)

SBQ:	101043955(FGB)

CIMI:

108282786(FGB)

ANAN:

105714552(FGB)

CSYR:

103268043(FGB)

MMUR:

105881781(FGB)

LCAT:

123638505(FGB)

PCOQ:

105811121(FGB)

OGA:	100953775(FGB)

MMU:	110135(Fgb)

MCAL:

110291148(Fgb)

MPAH:

110320684(Fgb)

RNO:	24366(Fgb)

MCOC:

116093039(Fgb)

ANU:	117707813(Fgb)

ASYL:

127683223(Fgb)

MUN:	110547216(Fgb)

CGE:	100770424(Fgb)

MAUA:

101833425(Fgb)

PROB:

127232782(Fgb)

PLEU:

114682942(Fgb)

MORG:

121452700(Fgb)

MFOT:

126511581

AAMP:

119826179(Fgb)

NGI:	103750993(Fgb)

HGL:	101698228(Fgb)

CPOC:

100726228(Fgb)

CCAN:

109684169(Fgb)

DORD:

105995829(Fgb)

DSP:	122127131(Fgb)

PLOP:

125341597(Fgb)

NCAR:

124994158

MMMA:

107141273(Fgb)

ITI:	101970473(Fgb)

OCU:

100351341

OPI:	101524446(FGB)

TUP:	102481171(FGB)

GVR:	103592060(FGB)

CFA:	475472(FGB)

CLUD:

112654635(FGB)

VVP:	112933464(FGB)

VLG:	121481626(FGB)

NPO:	129516763(FGB)

AML:	100466140(FGB)

UMR:	103658034(FGB)

UAH:	113255441(FGB)

UAR:	123793204(FGB)

ELK:

111157895

LLV:

125093122

MPUF:

101684675(FGB)

MNP:	132000964(FGB)

MLK:	131831534(FGB)

NVS:	122890506(FGB)

ORO:	101385652(FGB)

EJU:	114210152(FGB)

ZCA:	113924368(FGB)

MLX:	118022221(FGB)

NSU:	110588626(FGB)

LWW:	102739135(FGB)

FCA:	101099632(FGB)

PYU:	121028303(FGB)

PCOO:

112858467(FGB)

PBG:	122475245(FGB)

PVIV:

125164145(FGB)

LRUF:

124520896

LGF:	123591207(FGB)

AJU:

106982473

PTG:	102963657(FGB)

PPAD:

109262501(FGB)

PUC:

125923773

PLEZ:

122216961(FGB)

HHV:	120221622(FGB)

BTA:	510522(FGB)

BOM:	102284525(FGB)

BIU:	109571096(FGB)

BBUB:

102415912(FGB)

BBIS:

104989148(FGB)

CHX:	102184929(FGB)

OAS:	101102336(FGB)

BTAX:

128062424(FGB)

CSUM:

138093677(FGB)

ODA:	120871447(FGB)

CCAD:

122451322(FGB)

MREE:

136145711(FGB)

OVR:	110136090(FGB)

MBEZ:

129542867(FGB)

SSC:	100514354(FGB)

CFR:	102521525(FGB)

CBAI:

105079731(FGB)

CDK:	105089288(FGB)

VPC:	102526388(FGB)

BACU:

103000076(FGB)

BMUS:

118895672(FGB)

LVE:	103069063(FGB)

OOR:	101277474(FGB)

LALB:

132519228(FGB)

DLE:	111187747(FGB)

PCAD:

102980493(FGB)

PSIU:

116753813(FGB)

NASI:

112390728(FGB)

ECB:	100069774(FGB)

EPZ:	103553816(FGB)

EAI:	106832939(FGB)

MYB:	102259358(FGB)

MYD:	102759977(FGB)

MMYO:

118659125(FGB)

MLF:	102426218(FGB)

MDT:	132235449(FGB)

MYUM:

139010637(FGB)

PKL:	118711016(FGB)

EFUS:

103288484(FGB)

MNA:	107525621(FGB)

DRO:	112312668(FGB)

SHON:

118995381(FGB)

AJM:	119065902(FGB)

PDIC:

114503318(FGB)

PHAS:

123814092(FGB)

MMF:	118615871(FGB)

PPAM:

129061610(FGB)

HAI:	109381993(FGB)

RFQ:	117038320(FGB)

PALE:

102887435(FGB)

PGIG:

120613421(FGB)

PVP:	105292188(FGB)

RAY:	107507542(FGB)

MJV:	108406293(FGB)

TOD:	119234758(FGB)

SARA:

101541948(FGB)

SFUM:

130028376(FGB)

SETR:

126003443(FGB)

LAV:	100672464(FGB)

TMU:

101342093

ETF:	101644590(FGB)

DNM:	101437155(FGB)

MDO:	100024397(FGB)

GAS:	123251049(FGB)

SHR:	100930207(FGB)

AFZ:

127540314

PCW:	110213679(FGB)

TVP:	118853469(FGB)

PBRV:

138174844(FGB)

OAA:	100081434(FGB)

TACU:

119935658(FGB)

GGA:	373926(FGB)

PCOC:

116243142(FGB)

MGP:	100546139(FGB)

CJO:	107313034(FGB)

TPAI:

128084376(FGB)

LMUT:

125692424(FGB)

NMEL:

110398152(FGB)

APLA:

101793102(FGB)

ACYG:

106032371(FGB)

CATA:

118249164(FGB)

AFUL:

116489185(FGB)

TGU:	100223598(FGB)

LSR:	110470500(FGB)

SCAN:

103825966(FGB)

PMOA:

120497948(FGB)

OTC:	121348450(FGB)

PRUF:

121360223(FGB)

ATRC:

139592611(FGB)

GFR:	102045003(FGB)

FAB:	101812541(FGB)

OMA:	130252012(FGB)

PHI:	102105105(FGB)

PMAJ:

107203582(FGB)

CCAE:

111927838(FGB)

CCW:	104697171(FGB)

CBRC:

103617362(FGB)

ACOE:

138109692(FGB)

ETL:	114066329(FGB)

ZAB:	102068267(FGB)

ZLE:	135447323(FGB)

ACHL:

103802418(FGB)

SVG:	106861721(FGB)

MMEA:

130579280(FGB)

HRT:	120752776(FGB)

SATI:

136360448(FGB)

CCIC:

134044472(FGB)

FPG:	101923040(FGB)

FCH:	102059523(FGB)

CCRI:

104164107(FGB)

NNT:	104403842(FGB)

SHAB:

115610189(FGB)

ACUN:

113479606(FGB)

TALA:

104356021(FGB)

ACHC:

115340468(FGB)

HALD:

104324705(FGB)

HLE:	104843271(FGB)

AGEN:

126044728

HHAR:

128137094(FGB)

GCL:

127015918

CSTI:

104559798(FGB)

LDI:	104346795(FGB)

MNB:	103781301(FGB)

DPUB:

104298358(FGB)

PPUS:

135178435(FGB)

AVIT:

104276044(FGB)

BRHI:

104494605(FGB)

EGZ:	104124173(FGB)

NNI:	104021233(FGB)

PCRI:

104028881(FGB)

PCAO:

104049701(FGB)

PADL:

103921775(FGB)

AFOR:

103902285(FGB)

FGA:	104073793(FGB)

GSTE:

104260181(FGB)

CLV:	102085313(FGB)

MUI:	104540325(FGB)

PGUU:

104458652(FGB)

PLET:

104616540(FGB)

EHS:	104503649(FGB)

CMAC:

104479525(FGB)

CUCA:

104055267(FGB)

TEO:	104375633(FGB)

BREG:

104637301(FGB)

OHA:	104331615(FGB)

ACAR:

104521998(FGB)

CPEA:

104387196(FGB)

CVF:	104294129(FGB)

RTD:	128910426(FGB)

CRID:

134516525(FGB)

AAM:	106491906(FGB)

AROW:

112976723(FGB)

NPD:	112949308(FGB)

TGT:	104564478(FGB)

DNE:	112995281(FGB)

SCAM:

104145545(FGB)

ASN:	102379305(FGB)

AMJ:	102566445(FGB)

CPOO:

109309686(FGB)

GGN:	109300832(FGB)

PSS:	102456321(FGB)

CMY:	102937149(FGB)

CCAY:

125635582(FGB)

DCC:	119854741(FGB)

CPIC:

101950518(FGB)

TST:	117878594(FGB)

CABI:

116824068(FGB)

MRV:	120405858(FGB)

ACS:	100552725(fgb)

ASAO:

132776789(FGB)

PVT:	110072769(FGB)

SUND:

121931981(FGB)

PBI:	103052869(FGB)

PMUR:

107290653(FGB)

CTIG:

120309602(FGB)

TSR:	106553596(FGB)

PGUT:

117662117(FGB)

APRI:

131202994(FGB)

PTEX:

113435845(FGB)

NSS:	113417955(FGB)

VKO:	123023797(FGB)

PMUA:

114604333(FGB)

PRAF:

128420960(FGB)

ZVI:	118083667(FGB)

HCG:	128327886(FGB)

GJA:	107109449(FGB)

STOW:

125439911(FGB)

EMC:	129336890(FGB)

XLA:	108706652(fgb.S) 397825(fgb.L)

XTR:	594921(fgb)

NPR:	108788199(FGB)

RTEM:

120920084(FGB)

BBUF:

120990996(FGB)

BGAR:

122942573(FGB)

PWL:	138303621(FGB)

MUO:	115462220(FGB)

GSH:	117359019(FGB)

DRE:	337315(fgb)

SRX:

107714148

SANH:

107665922 107692638

SGH:

107564337

CCAR:

109078427(fgb)

CAUA:

113044503(fgb)

CGIB:

127949343

PTET:

122351763(fgb)

LROH:

127165236(fgb)

OMC:	131539349(fgb)

PPRM:

120463741(fgb)

RKG:	130096893(fgb)

MAMB:

125272755(fgb)

CIDE:

127521871

CERY:

137032555(fgb)

MASI:

127444155

TROS:

130552536(fgb)

TDW:	130438802(fgb)

MANU:

129444923(fgb)

PDAB:

135735773(fgb)

IPU:

108258914

IFU:	128601791(fgb)

PHYP:

113524553(fgb)

SMEO:

124377979(fgb)

TFD:	113652973(fgb)

TVC:	132839606(fgb)

CGAR:

128506210(fgb)

NGRA:

132865744(fgb)

TRN:	134329626(fgb)

AMEX:

103025155(fgb)

CMAO:

118798324(fgb)

EEE:	113574934(fgb)

CHAR:

105904872(fgb)

SPIL:

134059482(fgb)

TRU:	101068102(fgb)

TFS:	130522400(fgb)

TNG:	GSTEN00004568G001

LCO:	104938451(fgb)

NCC:	104947550(fgb)

TBEN:

117469889(fgb)

CGOB:

115005447(fgb)

PGEO:

117463576(fgb)

GACU:

117553678(fgb)

EMAC:

134876177(fgb)

ELY:	117272658(fgb)

EFO:	125883423(fgb)

SLUC:

116052116(fgb)

ECRA:

117962124(fgb)

ESP:	116690933(fgb)

PFLV:

114545709(fgb)

GAT:	120822685(fgb)

PPUG:

119222950(fgb)

AFB:	129093197(fgb)

CLUM:

117747536(fgb)

PSWI:

130212219(fgb)

CANA:

137781875(fgb)

CVE:	137874416(fgb)

MSAM:

119911819(fgb)

SCHU:

122870155(fgb)

CUD:	121504969(fgb)

SPUL:

138600880(fgb)

LMIX:

132967169(fgb)

ALAT:

119027471(fgb)

ASTR:

137590462(fgb)

MZE:	101466796(fgb)

ONL:	100689963(fgb)

OAU:	116326597(fgb)

OLA:	101172769(fgb)

OML:	112156452(fgb)

CSAI:

133420389(fgb)

XMA:	102224268(fgb)

XCO:	114157563(fgb)

XHE:	116732871(fgb)

PRET:

103460803(fgb)

PFOR:

103149047(fgb)

PLAI:

106947311(fgb)

PMEI:

106924271(fgb)

GAF:	122820994(fgb)

PPRL:

129351355 129376569

CVG:	107082287(fgb)

CTUL:

119797974(fgb)

GMU:	124880205(fgb)

NFU:	107376836(fgb)

KMR:	108248309(fgb)

ALIM:

106529236(fgb)

NWH:	119417321(fgb)

AOCE:

111587253(fgb)

EJA:	138214165(fgb)

BFRE:

138636555(fgb)

MCEP:

125009235(fgb)

CSEM:

103389626(fgb)

POV:	109646742(fgb)

SSEN:

122765863(fgb)

SSOE:

131457343(fgb)

HHIP:

117779109(fgb)

HSP:	118102679(fgb)

PPLT:

128430234(fgb)

SMAU:

118284266(fgb)

LCF:

108874851

SDU:	111240018(fgb)

SLAL:

111668171(fgb)

XGL:	120797266(fgb)

HCQ:	109507031(fgb)

SSCV:

125990712(fgb)

SBIA:

133494813(fgb)

PEE:	133397636(fgb)

PTAO:

133472727(fgb)

BPEC:

110160251(fgb)

ENY:	140371646(fgb)

MALB:

109972932(fgb)

BSPL:

114851253(fgb)

SJO:	128384083(fgb)

SSCO:

134006110(fgb)

GMH:	115529423(fgb)

SASA:

106578170 106590856 106613451

STRU:

115194895(fgb)

OTW:	112240139(fgb) 121839428

OMY:	110531328 110536443 118959894

OGO:	124008318 124013883

OKI:	109885568(fgb)

OKE:	118377092 118378694

OMM:	135510218 135516501

OCLA:

139379130 139415795

SALP:

112076407(fgb)

SNH:	120030182 120041434

CCLU:

121558043 121571067

ELS:	105030631(fgb)

OEP:	134016554(fgb)

SFM:	108936645(fgb)

PKI:	111833016(fgb)

AANG:

118231817(fgb)

AROT:

135259753(fgb)

CCOG:

133135298(fgb)

LOC:	102699135(fgb)

PSPA:

121295158(fgb)

ARUT:

117408656(fgb)

PSEX:

120527153(fgb)

LCM:	102362367(FGB)

CMK:	103189383(fgb)

RTP:	109916207(fgb)

CPLA:

122553699(fgb)

HOC:	132818024(fgb)

LERI:

129702603(fgb)

PMRN:

103091734(FGB)

LRJ:	133342946(FGB)

» show all

Reference

PMID:6688356

Authors

Chung DW, Que BG, Rixon MW, Mace M Jr, Davie EW

Title

Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen.

Journal

Biochemistry 22:3244-50 (1983)
DOI:10.1021/bi00282a032

Sequence

[hsa:2244]

Reference

PMID:16102057

Authors

Mosesson MW

Title

Fibrinogen and fibrin structure and functions.

Journal

J Thromb Haemost 3:1894-904 (2005)
DOI:10.1111/j.1538-7836.2005.01365.x

Reference

PMID:22273812

Authors

Jeff JM, Brown-Gentry K, Crawford DC

Title

Replication and characterisation of genetic variants in the fibrinogen gene cluster with plasma fibrinogen levels and haematological traits in the Third National Health and Nutrition Examination Survey.

Journal

Thromb Haemost 107:458-67 (2012)
DOI:10.1160/TH11-07-0497

Sequence

[hsa:2244]

LinkDB

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