KEGG ORTHOLOGY: K05060

ORTHOLOGY: K05060

Entry

K05060                      KO

Symbol

IL6ST, GP130, CD130

Name

interleukin 6 signal transducer

Pathway

map04060

Cytokine-cytokine receptor interaction

map04061

Viral protein interaction with cytokine and cytokine receptor

map04550

Signaling pathways regulating pluripotency of stem cells

map04630

JAK-STAT signaling pathway

map04659

Th17 cell differentiation

map05167

Kaposi sarcoma-associated herpesvirus infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05203

Viral carcinogenesis

Disease

H00462

Stuve-Wiedemann syndrome

H01968

Hyper-IgE syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
   05203 Viral carcinogenesis
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
   04090 CD molecules
    K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
Cytokine receptors [BR:ko04050]
Interleukin receptor families
  IL6/12 receptor family
   K05060  IL6ST, GP130, CD130; interleukin 6 signal transducer
CD molecules [BR:ko04090]
Proteins
  K05060  CD130, IL6ST; interleukin 6 signal transducer (gp130, oncostatin M receptor)

Other DBs

GO:

0004915

Genes

HSA:	3572(IL6ST)

PTR:	461866(IL6ST)

PPS:	100992032(IL6ST)

GGO:	101153224(IL6ST)

PON:	100451191(IL6ST)

NLE:	100581824(IL6ST)

HMH:	116463892(IL6ST)

MCC:	574127(IL6ST)

MCF:	101926138(IL6ST)

MTHB:

126957544

MNI:	105499399(IL6ST)

CSAB:

103221611(IL6ST)

CATY:

105599628(IL6ST)

PANU:

100998383(IL6ST)

TGE:	112625906(IL6ST)

MLEU:

105551494(IL6ST)

RRO:	104680478(IL6ST)

RBB:	108530957(IL6ST)

TFN:	117065139(IL6ST)

PTEH:

111541627(IL6ST)

CANG:

105512469(IL6ST)

CJC:	100396729(IL6ST)

SBQ:	101029979(IL6ST)

CIMI:

108317975(IL6ST)

CSYR:

103258794(IL6ST)

MMUR:

105877286(IL6ST)

LCAT:

123647990(IL6ST)

PCOQ:

105819129(IL6ST)

OGA:	100958958(IL6ST)

MMU:	16195(Il6st)

MCAL:

110307804(Il6st)

MPAH:

110328878(Il6st)

RNO:	25205(Il6st)

MCOC:

116083943(Il6st)

ANU:	117723760(Il6st)

MUN:	110546647(Il6st)

CGE:	100767181(Il6st)

MAUA:

101842747(Il6st)

PROB:

127221151(Il6st)

PLEU:

114703579(Il6st)

MORG:

121455663(Il6st)

MFOT:

126507925

AAMP:

119808804(Il6st)

NGI:	103739911(Il6st)

HGL:	101703833(Il6st)

CPOC:

100724018(Il6st)

CCAN:

109700609(Il6st)

DORD:

105987287(Il6st)

DSP:	122117279(Il6st)

PLOP:

125367391(Il6st)

NCAR:

124986719

MMMA:

107151880(Il6st)

OCU:

100349330

OPI:	101523596(IL6ST)

TUP:	102494199(IL6ST)

GVR:	103588371(IL6ST)

CFA:	403545(IL6ST)

CLUD:

112660681(IL6ST)

VVP:	112935199(IL6ST)

VLG:	121496704(IL6ST)

NPO:	129513576(IL6ST)

AML:	100483131(IL6ST)

UMR:	103663669(IL6ST)

UAH:	113255323(IL6ST)

UAR:	123790182(IL6ST)

ELK:

111156948

LLV:

125099966

MPUF:

101691642(IL6ST)

MNP:	132028647(IL6ST)

MLK:	131832243(IL6ST)

NVS:	122889456(IL6ST)

ORO:	101368221(IL6ST)

EJU:	114220972(IL6ST)

ZCA:	113929940(IL6ST)

MLX:	118016794(IL6ST)

NSU:	110590912(IL6ST)

LWW:

102733408

FCA:	101089832(IL6ST)

PYU:	121015786(IL6ST)

PCOO:

112860883(IL6ST)

PBG:	122489075(IL6ST)

PVIV:

125155182(IL6ST)

LRUF:

124517290

PTG:	102968948(IL6ST)

PPAD:

109246341(IL6ST)

PUC:

125935635

AJU:

106975253

HHV:	120239954(IL6ST)

BTA:	522155(IL6ST)

BOM:	102280532(IL6ST)

BIU:	109574817(IL6ST)

BBUB:

102405590(IL6ST)

BBIS:

104998380(IL6ST)

CHX:	102188086(IL6ST)

OAS:	101113174(IL6ST)

BTAX:

128066072(IL6ST)

ODA:	120879525(IL6ST)

CCAD:

122454224(IL6ST)

MBEZ:

129553248(IL6ST)

SSC:	100037294(IL6ST)

CFR:	102511873(IL6ST)

CBAI:

105077802(IL6ST)

CDK:	105087138(IL6ST)

VPC:	102529144(IL6ST)

BACU:

103000073(IL6ST)

BMUS:

118891872(IL6ST)

LVE:	103075698(IL6ST)

OOR:	101287401(IL6ST)

DLE:	111186578(IL6ST)

PCAD:

102982237(IL6ST)

PSIU:

116751175(IL6ST)

NASI:

112413398(IL6ST)

ECB:	100051700(IL6ST)

EPZ:	103548204(IL6ST)

EAI:	106843367(IL6ST)

MYB:	102253606(IL6ST)

MYD:	102763204(IL6ST)

MMYO:

118655807(IL6ST)

MLF:	102441934 102443066(IL6ST)

PKL:	118702983(IL6ST)

EFUS:

103303119(IL6ST)

MNA:	107527134(IL6ST)

DRO:	112315251(IL6ST)

SHON:

118981655(IL6ST)

AJM:	119049182(IL6ST)

PDIC:

114502072(IL6ST)

PHAS:

123819500(IL6ST)

MMF:	118642413(IL6ST)

PPAM:

129071973(IL6ST)

HAI:	109382150(IL6ST)

RFQ:	117024735(IL6ST)

PALE:

102880415(IL6ST)

PGIG:

120608187(IL6ST)

PVP:	105299364(IL6ST)

RAY:	107509633(IL6ST) 107518627

MJV:	108393228(IL6ST)

TOD:	119261463(IL6ST)

SARA:

101551921(IL6ST)

SETR:

126000929(IL6ST)

LAV:	100669556(IL6ST)

TMU:

101353064

ETF:	101646676(IL6ST)

DNM:	101441436(IL6ST)

MDO:	100017284(IL6ST)

GAS:	123237164(IL6ST)

SHR:	100913307(IL6ST)

AFZ:

127557536

PCW:	110215675(IL6ST)

OAA:	100073530(IL6ST)

GGA:	395684(IL6ST)

PCOC:

116239417(IL6ST)

MGP:

100550313

CJO:	107305990(IL6ST)

TPAI:

128074507(IL6ST)

LMUT:

125686778(IL6ST)

NMEL:

110389606(IL6ST)

APLA:

101799928(IL6ST)

ACYG:

106035611(IL6ST)

CATA:

118251514(IL6ST)

AFUL:

116501212(IL6ST)

TGU:	100226842(IL6ST)

LSR:	110472554(IL6ST)

SCAN:

103821034(IL6ST)

PMOA:

120502492(IL6ST)

OTC:	121337736(IL6ST)

PRUF:

121355302(IL6ST)

GFR:	102036418(IL6ST)

FAB:	101807050(IL6ST)

OMA:	130264882(IL6ST)

PHI:	102107918(IL6ST)

PMAJ:

107198202(IL6ST)

CCAE:

111941441(IL6ST)

CCW:	104686676(IL6ST)

CBRC:

103623859(IL6ST)

ETL:	114065911(IL6ST)

ZAB:	102064531(IL6ST)

ACHL:

103811506

SVG:	106859619(IL6ST)

MMEA:

130588694(IL6ST)

HRT:	120765107(IL6ST)

FPG:	101911352(IL6ST)

FCH:	102051353(IL6ST)

CLV:	102094030(IL6ST)

EGZ:	104134682(IL6ST)

NNI:	104013731(IL6ST) 104014605

PCRI:

104035606(IL6ST)

PLET:

104625570(IL6ST)

EHS:

104513183

PCAO:

104046321(IL6ST)

ACUN:

113489579(IL6ST)

TALA:

104360147(IL6ST)

PADL:

103919426(IL6ST)

AFOR:

103893399(IL6ST)

ACHC:

115337289(IL6ST)

HALD:

104311316(IL6ST)

HLE:	104839948(IL6ST)

AGEN:

126036446

GCL:	127027095 127029099

CCRI:

104165720

CSTI:

104556346(IL6ST)

CMAC:

104474245(IL6ST)

MUI:	104547229(IL6ST)

BREG:

104637609(IL6ST)

FGA:	104070239(CSF3R)

GSTE:

104251240(IL6ST)

LDI:	104342528(IL6ST)

MNB:	103779984(IL6ST)

OHA:	104337795(IL6ST)

NNT:	104402782(IL6ST)

SHAB:

115619787(IL6ST)

DPUB:

104296756(IL6ST)

PGUU:

104470475

ACAR:

104524582(IL6ST)

CPEA:

104395628(IL6ST)

AVIT:

104270101

CVF:	104294995(IL6ST)

RTD:	128902409(IL6ST)

CUCA:

104054806(IL6ST)

TEO:	104373318(IL6ST)

BRHI:

104500331(IL6ST)

AAM:

106496354

AROW:

112960895(IL6ST)

NPD:	112945657(IL6ST)

TGT:	104575740 104579128(IL6ST)

DNE:	112995745(IL6ST)

SCAM:

104146855(IL6ST)

ASN:	102376353(IL6ST)

AMJ:	102559273(IL6ST)

CPOO:

109307922(IL6ST)

GGN:	109297812(IL6ST)

PSS:	102460174(IL6ST)

CMY:	102933394(IL6ST)

CCAY:

125627293 125637431(IL6ST)

DCC:	119848324 119855770(IL6ST)

CPIC:

101932922(IL6ST) 101952357

TST:	117869078 117878776(IL6ST)

CABI:

116818241(IL6ST) 116838490

MRV:	120407778(IL6ST)

ACS:	100562134(il6st) 103277600

ASAO:

132766997(IL6ST) 132781481

PVT:	110079290 110085393(IL6ST)

SUND:

121920678(IL6ST) 121936948

PBI:	103057304 112542239 112542588

PMUR:

107294972(IL6ST) 107300506

CTIG:

120313516(IL6ST)

TSR:	106546253(IL6ST) 106546711

PGUT:

117679200(IL6ST)

PTEX:

113446884(IL6ST)

NSS:	113413897(IL6ST)

VKO:	123031593(IL6ST)

PMUA:

114588695 114606170 114606832

PRAF:

128423246 128423686

ZVI:	118077334(IL6ST) 118086030

HCG:	128344904(IL6ST)

GJA:

107113291

STOW:

125436715(IL6ST)

EMC:	129334317(IL6ST)

XLA:	100158347(il6st.L) 100174791(il6st.S)

XTR:	100489642(il6st)

NPR:	108792012(IL6ST)

RTEM:

120928395(IL6ST)

BBUF:

120992142(IL6ST)

BGAR:

122925178(IL6ST)

MUO:	115462994(IL6ST)

GSH:	117354145(IL6ST)

DRE:	100006778(il6st)

SRX:	107715880 107737037

SANH:

107670041 107702582

SGH:	107558262 107560412

CCAR:

109052348 109097267

CAUA:

113053994 113109553

CGIB:

127965846 128021434

PTET:

122352748(il6st)

LROH:

127171999(il6st)

OMC:	131548471(il6st)

PPRM:

120482034(il6st)

MAMB:

125255827(il6st)

CIDE:

127520522

MASI:

127432334 127433366

TROS:

130545905(il6st)

TDW:	130411742(il6st)

MANU:

129445799(il6st)

IPU:	108265121 108276998(il6st)

IFU:

PHYP:

SMEO:

TFD:

TVC:

AMEX:

103042008 103042209(il6st)

CMAO:

118819526 118825112(il6st)

EEE:	113570988 113576765 113576766

CHAR:

105894607(il6st) 116222992

TRU:	101062203 101064175(il6st) 105416441

TFS:	130514650(il12rb2l) 130517079(il6st) 130525702

TNG:	GSTEN00009012G001

LCO:	104933465 104933784 104935192

TBEN:

117473070 117476801 117478864 117479018 117492640(il12rb2l)

CGOB:

115012860 115012984 115016624(il6st) 115027698

PGEO:

117451041(il12rb2l) 117452481 117456270(il6st) 117467437

GACU:

117534883(il6st) 117540516 117554452(il12rb2l) 117555372

EMAC:

134868374(il6st) 134873385 134877886(il12rb2l) 134881953

ELY:	117252812 117266832 117267794(il12rb2l) 117269354(il6st)

EFO:	125880081(il12rb2l) 125890780 125901061 125905796(il6st)

PLEP:

121954127 121956460(il12rb2l) 121959563(il6st)

SLUC:

116041458(il6st) 116054394 116057714 116059531(il12rb2l)

ECRA:

117936155 117944399 117957407(il12rb2l) 117959350(il6st)

ESP:	116669632 116689052 116703594 116704591(il6st)

PFLV:

114547305 114555836 114569734 114570890(il6st)

GAT:	120827524(il12rb2l) 120830148 120831482(il6st)

PPUG:

119221050(il12rb2l) 119224839 119226627(il6st)

AFB:	129098483(il12rb2l) 129100878 129102152(il6st) 129103642

CLUM:

117735037(il12rb2l) 117740125(il6st)

PSWI:

130189258(il12rb2l) 130205360(il6st)

MSAM:

119888331(il12rb2l) 119891872 119910425 119915140(il6st)

SCHU:

122862102 122865144(il6st) 122868436(il12rb2l) 122876052

CUD:	121509454 121524829 121525110 121526716 121529324(il12rb2l)

ALAT:

119004967 119013413(il12rb2l) 119019911 119030470(il6st)

MZE:	101465095 101476931(il6st) 101481305 112432603

ONL:	100700123 100703251 100706260(il6st) 100710927

OAU:	116313567 116315646(il12rb2l) 116318031 116319152(il6st)

OLA:	101163013 101167043 101172130(il6st) 105356917

OML:	112137718 112140342(il6st) 112142567 112146293(il12rb2l)

CSAI:

133420418 133422468(il12rb2l) 133425119 133425377 133462129

XMA:	102219847(il6st) 102226847

XCO:	114134540 114149108(il6st)

XHE:	116709551 116724154(il6st) 116729712 116736040

PRET:

103458450 103473124(il6st)

PFOR:

103145475 103146571 103152649 103153225

PLAI:

106937885(il6st) 106947786 106962241 106962441

PMEI:

106905374(il6st) 106918996 106922796 106930939

GAF:	122822432(il12rb2l) 122828531 122846249 122847131(il6st)

PPRL:

129363456(il12rb2l) 129365232 129366093 129379791(il6st)

CVG:	107084616 107102482(il6st)

CTUL:

119775733 119777669(il12rb2l) 119784846 119788485(il6st)

GMU:	124862255 124864466 124872610(il6st) 124877183 124884898

NFU:	107386188 107392137 107394971(il6st)

KMR:	108239198(il12rb2l) 108242572(il6st) 108242804

ALIM:

106513790(il6st) 106521888 106528396

NWH:	119413005 119420953(il12rb2l) 119424484(il6st) 119427679

AOCE:

111573454 111579143(il6st) 111587984

MCEP:

124996241(il6st) 124998022(il12rb2l) 125012211

CSEM:

103381225 103389161(il6st)

POV:	109636341 109643155(il6st)

SSEN:

122758349(il6st) 122769550 122784900

HHIP:

117755955 117766318(il12rb2l) 117771410(il6st)

HSP:	118116784 118122769(il12rb2l) 118125991(il6st)

SMAU:

118285077(il6st) 118286499 118288964(il12rb2l)

LCF:	108874928 108877693 108880437(il12rb2l) 108881656

SDU:	111221084(il6st) 111238541

SLAL:

111645686 111659627(il6st) 111673116

XGL:	120788231(il12rb2l) 120805689 120806330(il6st)

HCQ:	109530464(il6st)

SSCV:

125979804

SBIA:

133491024(il6st) 133514864(il12rb2l)

PEE:	133414047(il6st) 133415278(il12rb2l)

PTAO:

133465263(il6st) 133466184(il12rb2l)

BPEC:

110154993 110161686(il6st) 110171118

MALB:

109957337 109960748(il6st)

BSPL:

114848958 114861040(il12rb2l) 114862293 114867260(il6st)

SJO:	128364328 128374910 128379461(il12rb2l) 128380242(il6st)

SASA:

106562893 106568321 106571489 106606534

STRU:

115160086 115171739 115192602 115203782 115206127

OTW:	112220134 112230733 112240990(il12rb2l) 121840864

OMY:	101268915(gp130) 110486918 110509538 110522754 110537852

OGO:	123989494 123999130 124016629 124037053

ONE:	115118184 115147123

OKI:	109868105 109873548 109877746

OKE:	118358734 118374836(il12rb2l) 118385560 118388046

SALP:

111963817 111971668

SNH:	120021190 120025724 120041238 120052047

CCLU:

121539907 121541399 121551442 121581972

ELS:	105013144 105021723(il6st)

SFM:	108921565 108929965(il6st)

PKI:	111834479(il6st) 111836578

AANG:

118212691 118221791

LOC:	102695320(il6st) 107079649

PSPA:

121300926 121316741 121326973

ARUT:

117400844 117400845 117408764 117408765 117428866 117966339

PSEX:

120532608(il6st)

LCM:	102356131 102357816(IL6ST)

CMK:	103177817(il6st) 103177818 103177873

RTP:

109916916

CPLA:

122549289 122549302 122549305 122565377

HOC:	132805452 132813874 132818965

LERI:

129696504 129696516 129711330

PMRN:

116943329

LRJ:	133346376 133351930

BBEL:

109487790 109487791

CIN:	100135649(gp130-like)

APLC:

110977732 110977766 110985797

PJA:

PCHN:

PCLA:

RSAN:

VJA:

BGT:	106059238 106075307

GAE:

121375836

HRF:	124114804 124114805 124114810

HRJ:	124275147 124275275 124286491 124286521 124286524 124286532

CRG:

105322392

MYI:	110463908 110463910

PMAX:

117322109 117325807 117326355

OSN:

115218400

» show all

Reference

PMID:2261637

Authors

Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T

Title

Molecular cloning and expression of an IL-6 signal transducer, gp130.

Journal

Cell 63:1149-57 (1990)
DOI:10.1016/0092-8674(90)90411-7

Sequence

[hsa:3572]

LinkDB

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