Homo sapiens (human): 2879
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Entry
2879 CDS
T01001
Symbol
GPX4, GPx-4, GSHPx-4, MCSP, PHGPx, SMDS, snGPx, snPHGPx
Name
(RefSeq) glutathione peroxidase 4
KO
K05361
phospholipid-hydroperoxide glutathione peroxidase [EC:
1.11.1.12
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00480
Glutathione metabolism
hsa01100
Metabolic pathways
hsa04216
Ferroptosis
Network
nt06026
Glutathione biosynthesis
Element
N00899
Glutathione biosynthesis
Disease
H01825
Spondylometaphyseal dysplasia, Sedaghatian type
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09106 Metabolism of other amino acids
00480 Glutathione metabolism
2879 (GPX4)
09140 Cellular Processes
09143 Cell growth and death
04216 Ferroptosis
2879 (GPX4)
Enzymes [BR:
hsa01000
]
1. Oxidoreductases
1.11 Acting on a peroxide as acceptor
1.11.1 Peroxidases
1.11.1.12 phospholipid-hydroperoxide glutathione peroxidase
2879 (GPX4)
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SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
GSHPx
AhpC-TSA
Motif
Other DBs
NCBI-GeneID:
2879
NCBI-ProteinID:
NP_002076
OMIM:
138322
HGNC:
4556
Ensembl:
ENSG00000167468
Vega:
OTTHUMG00000181874
Pharos:
P36969
(Tbio)
UniProt:
P36969
Structure
PDB
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All DBs
Position
19:1103994..1106779
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AA seq
197 aa
AA seq
DB search
MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR
GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA
AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRY
GPMEEPLVIEKDLPHYF
NT seq
594 nt
NT seq
+upstream
nt +downstream
nt
atgagcctcggccgcctttgccgcctactgaagccggcgctgctctgtggggctctggcc
gcgcctggcctggccgggaccatgtgcgcgtcccgggacgactggcgctgtgcgcgctcc
atgcacgagttttccgccaaggacatcgacgggcacatggttaacctggacaagtaccgg
ggcttcgtgtgcatcgtcaccaacgtggcctcccagtgaggcaagaccgaagtaaactac
actcagctcgtcgacctgcacgcccgatacgctgagtgtggtttgcggatcctggccttc
ccgtgtaaccagttcgggaagcaggagccagggagtaacgaagagatcaaagagttcgcc
gcgggctacaacgtcaaattcgatatgttcagcaagatctgcgtgaacggggacgacgcc
cacccgctgtggaagtggatgaagatccaacccaagggcaagggcatcctgggaaatgcc
atcaagtggaacttcaccaagttcctcatcgacaagaacggctgcgtggtgaagcgctac
ggacccatggaggagcccctggtgatagagaaggacctgccccactatttctag
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