KEGG   ORTHOLOGY: K07514
Entry
K07514                      KO                                     
Symbol
EHHADH
Name
enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
Pathway
map00071  Fatty acid degradation
map00280  Valine, leucine and isoleucine degradation
map00310  Lysine degradation
map00380  Tryptophan metabolism
map00410  beta-Alanine metabolism
map00627  Aminobenzoate degradation
map00640  Propanoate metabolism
map00650  Butanoate metabolism
map00930  Caprolactam degradation
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01212  Fatty acid metabolism
map03320  PPAR signaling pathway
map04146  Peroxisome
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00087  beta-Oxidation
Reaction
R01975  (S)-3-hydroxybutanoyl-CoA:NAD+ oxidoreductase
R03026  (S)-3-hydroxybutanoyl-CoA hydro-lyase
R03045  3-hydroxypropionyl-CoA hydro-lyase
R04137  3-hydroxyisovaleryl-CoA hydro-lyase
R04170  (S)-3-hydroxydodecanoyl-CoA hydro-lyase
R04203  (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA:NAD+ oxidoreductase
R04204  (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase
R04224  (S)-3-hydroxyisobutyryl-CoA hydro-lyase
R04737  (S)-3-hydroxyhexadecanoyl-CoA:NAD+ oxidoreductase
R04738  (S)-3-hydroxyhexadecanoyl-CoA hydro-lyase
R04739  (S)-3-hydroxytetradecanoyl-CoA:NAD+ oxidoreductase
R04740  (S)-3-hydroxytetradecanoyl-CoA hydro-lyase
R04741  (S)-3-hydroxydodecanoyl-CoA:NAD+ oxidoreductase
R04743  (S)-hydroxydecanoyl-CoA:NAD+ oxidoreductase
R04744  (S)-hydroxydecanoyl-CoA hydro-lyase
R04745  (S)-hydroxyoctanoyl-CoA:NAD+ oxidoreductase
R04746  (S)-hydroxyoctanoyl-CoA hydro-lyase
R04748  (S)-hydroxyhexanoyl-CoA:NAD+ oxidoreductase
R04749  (S)-hydroxyhexanoyl-CoA hydro-lyase
R04756  cis,cis-3,6-dodecadienoyl-CoA delta3-cis-delta2-trans-isomerase
R05595  
R06941  (S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase
R06942  (3S)-3-hydroxyacyl-CoA hydro-lyase
Disease
H01198  Fanconi renotubular syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00650 Butanoate metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00310 Lysine degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00380 Tryptophan metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09111 Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00930 Caprolactam degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.8  Delta3-Delta2-enoyl-CoA isomerase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
Other DBs
GO: 0004300 0003857 0004165
Genes
HSA: 1962(EHHADH)
PTR: 460996(EHHADH)
PPS: 100985141(EHHADH)
GGO: 101130472(EHHADH)
PON: 100174685(EHHADH)
NLE: 100586768(EHHADH)
HMH: 116479922(EHHADH)
MCC: 701193(EHHADH)
MCF: 102118537(EHHADH)
MTHB: 126948446
MNI: 105480141(EHHADH)
CSAB: 103221115(EHHADH)
CATY: 105573959(EHHADH)
PANU: 100997048(EHHADH)
TGE: 112619647(EHHADH)
MLEU: 105541035(EHHADH)
RRO: 104672740(EHHADH)
RBB: 108525336(EHHADH)
TFN: 117083838(EHHADH)
PTEH: 111523217(EHHADH)
CANG: 105514476(EHHADH)
CJC: 100395397(EHHADH)
SBQ: 101049266(EHHADH)
CIMI: 108311091(EHHADH)
CSYR: 103253098
MMUR: 105863069(EHHADH)
LCAT: 123630345(EHHADH)
PCOQ: 105808288(EHHADH)
OGA: 100965096(EHHADH)
MMU: 74147(Ehhadh)
MCAL: 110311920(Ehhadh)
MPAH: 110330110(Ehhadh)
RNO: 171142(Ehhadh)
MCOC: 116085740(Ehhadh)
ANU: 117702132 117717517(Ehhadh)
MUN: 110561900(Ehhadh)
CGE: 100754698(Ehhadh)
MAUA: 101832275(Ehhadh)
PROB: 127226986(Ehhadh)
MORG: 121465101(Ehhadh)
MFOT: 126504179
AAMP: 119825175(Ehhadh)
NGI: 103732668(Ehhadh)
HGL: 101699730(Ehhadh)
CCAN: 109695163
PLOP: 125351917
OCU: 100346381
OPI: 101522356(EHHADH)
TUP: 102502891(EHHADH)
GVR: 103591460(EHHADH)
CFA: 488110(EHHADH)
CLUD: 112662628(EHHADH)
VVP: 112926276(EHHADH)
VLG: 121477417(EHHADH)
NPO: 129498716(EHHADH)
AML: 100468058(EHHADH)
UMR: 103676178(EHHADH)
UAH: 113254101(EHHADH)
UAR: 123778934(EHHADH)
ELK: 111150208
LLV: 125101702
MPUF: 101685945(EHHADH)
MNP: 132011971(EHHADH)
MLK: 131824775(EHHADH)
NVS: 122908770(EHHADH)
ORO: 101370722(EHHADH)
EJU: 114207180(EHHADH)
ZCA: 113918332(EHHADH)
MLX: 118006911(EHHADH)
NSU: 110582430(EHHADH)
LWW: 102732268(EHHADH)
FCA: 101083876(EHHADH)
PYU: 121034100(EHHADH)
PCOO: 112850204(EHHADH)
PBG: 122491648(EHHADH)
LRUF: 124526811
PTG: 102965690(EHHADH)
PPAD: 109275245(EHHADH)
PUC: 125921106
AJU: 106967987
HHV: 120238074(EHHADH)
BTA: 518852(EHHADH)
BOM: 102285943(EHHADH)
BIU: 109557289(EHHADH)
BBUB: 102404255(EHHADH)
BBIS: 104998607(EHHADH)
CHX: 102179598(EHHADH)
OAS: 101117635(EHHADH)
BTAX: 128054724(EHHADH)
ODA: 120872222(EHHADH)
CCAD: 122444841(EHHADH)
MBEZ: 129544984(EHHADH)
SSC: 448846(EHHADH)
CFR: 102519802(EHHADH)
CBAI: 105072312(EHHADH)
CDK: 105085864(EHHADH)
VPC: 102535563(EHHADH)
BACU: 102997304(EHHADH)
LVE: 103073756(EHHADH)
OOR: 101277611(EHHADH)
DLE: 111173099(EHHADH)
PCAD: 102985760(EHHADH)
PSIU: 116753374(EHHADH)
NASI: 112415146(EHHADH)
ECB: 100067714(EHHADH)
EPZ: 103565918(EHHADH)
EAI: 106834502(EHHADH)
MYB: 102240784(EHHADH)
MYD: 102771761(EHHADH)
MMYO: 118676759(EHHADH)
MLF: 102438879(EHHADH)
MNA: 107527318(EHHADH)
PKL: 118723609(EHHADH)
EFUS: 103300660(EHHADH)
HAI: 109396830(EHHADH)
DRO: 112308135(EHHADH)
SHON: 119004236(EHHADH)
AJM: 119038747(EHHADH)
PDIC: 114490871(EHHADH)
PHAS: 123827199(EHHADH)
MMF: 118617797(EHHADH)
RFQ: 117036016(EHHADH)
PPAM: 129079845(EHHADH)
PALE: 102880064(EHHADH)
PGIG: 120592913(EHHADH)
PVP: 105306896(EHHADH)
RAY: 107518255(EHHADH)
TOD: 119257360(EHHADH)
SARA: 101544136(EHHADH)
LAV: 100677184(EHHADH)
TMU: 101352903
ETF: 101653713(EHHADH)
DNM: 101423565(EHHADH)
MDO: 100026751(EHHADH)
GAS: 123244682(EHHADH)
SHR: 100913272(EHHADH)
AFZ: 127563515
PCW: 110221285(EHHADH)
OAA: 100082172(EHHADH)
GGA: 424877(EHHADH)
PCOC: 116231030(EHHADH)
MGP: 100551164(EHHADH)
CJO: 107317934(EHHADH)
TPAI: 128082767(EHHADH)
LMUT: 125697493(EHHADH)
NMEL: 110398159(EHHADH)
APLA: 101795970(EHHADH)
ACYG: 106039208(EHHADH)
CATA: 118246948(EHHADH)
AFUL: 116492724(EHHADH)
TGU: 100229171(EHHADH)
LSR: 110474075(EHHADH)
SCAN: 103815479(EHHADH)
PMOA: 120496450(EHHADH)
OTC: 121342163(EHHADH)
PRUF: 121364038(EHHADH)
GFR: 102040622(EHHADH)
FAB: 101818793(EHHADH)
OMA: 130256565(EHHADH)
PHI: 102112202(EHHADH)
PMAJ: 107208675(EHHADH)
CCAE: 111945334(EHHADH)
CCW: 104696695(EHHADH)
CBRC: 103612410(EHHADH)
ETL: 114054815(EHHADH)
ZAB: 102060514(EHHADH)
ACHL: 103804661(EHHADH)
SVG: 106849693(EHHADH)
MMEA: 130581492(EHHADH)
HRT: 120757095(EHHADH)
FPG: 101918474(EHHADH)
FCH: 102057870(EHHADH)
CLV: 102091542(EHHADH)
EGZ: 104131306(EHHADH)
NNI: 104010666(EHHADH)
PCRI: 104035898(EHHADH)
PLET: 104621252(EHHADH)
EHS: 104515039(EHHADH)
PCAO: 104052498(EHHADH)
ACUN: 113483679(EHHADH)
TALA: 104358391(EHHADH)
PADL: 103916934(EHHADH)
AFOR: 103903731(EHHADH)
ACHC: 115347400(EHHADH)
HALD: 104317864(EHHADH)
HLE: 104827863(EHHADH)
AGEN: 126039798
GCL: 127020128
CCRI: 104166182(EHHADH)
CSTI: 104558711(EHHADH)
CMAC: 104474898(EHHADH)
MUI: 104546147(EHHADH)
BREG: 104634099(EHHADH)
FGA: 104075194(EHHADH)
GSTE: 104256732(EHHADH)
LDI: 104342572(EHHADH)
MNB: 103776383(EHHADH)
OHA: 104335115(EHHADH)
NNT: 104409816(EHHADH)
SHAB: 115611825(EHHADH)
DPUB: 104305530(EHHADH)
PGUU: 104463689(EHHADH)
ACAR: 104519549(EHHADH)
CPEA: 104385120(EHHADH)
AVIT: 104269201(EHHADH)
CVF: 104288562(EHHADH)
RTD: 128911683(EHHADH)
CUCA: 104066360(EHHADH)
TEO: 104380371(EHHADH)
BRHI: 104495582(EHHADH)
AAM: 106493091(EHHADH)
AROW: 112970787(EHHADH)
NPD: 112946774(EHHADH)
TGT: 104565507(EHHADH)
DNE: 112983448(EHHADH)
SCAM: 104154206(EHHADH)
ASN: 102381971(EHHADH)
AMJ: 102558567(EHHADH)
CPOO: 109315316(EHHADH)
GGN: 109287805(EHHADH)
PSS: 102453335(EHHADH)
CMY: 102939101(EHHADH)
CCAY: 125642408(EHHADH)
DCC: 119861746(EHHADH)
CPIC: 101941626(EHHADH)
TST: 117882621(EHHADH)
CABI: 116815340(EHHADH)
MRV: 120372509(EHHADH)
ACS: 100558466(ehhadh)
ASAO: 132770771(EHHADH)
PVT: 110075819(EHHADH)
SUND: 121927038(EHHADH)
PBI: 103052873(EHHADH)
PMUR: 107285887(EHHADH)
CTIG: 120313906(EHHADH)
TSR: 106540162(EHHADH)
PGUT: 117678501(EHHADH)
APRI: 131200954(EHHADH)
PTEX: 113436767(EHHADH)
NSS: 113426038(EHHADH)
VKO: 123025753(EHHADH)
PMUA: 114597690(EHHADH)
PRAF: 128414455(EHHADH)
ZVI: 118093712(EHHADH)
HCG: 128351913(EHHADH)
GJA: 107123582(EHHADH)
STOW: 125438180(EHHADH)
EMC: 129331804(EHHADH)
XLA: 108703045(ehhadh.S)
XTR: 100216115(ehhadh)
NPR: 108795601(EHHADH)
RTEM: 120943840(EHHADH)
BBUF: 121007524(EHHADH)
BGAR: 122945387(EHHADH)
MUO: 115473831(EHHADH)
GSH: 117360921(EHHADH)
DRE: 100000859(ehhadh)
SRX: 107749878(ehhadh)
SANH: 107663901(ehhadh)
SGH: 107596516
CAUA: 113108839(ehhadh)
CGIB: 127965244
PTET: 122351568(ehhadh)
LROH: 127171390(ehhadh)
OMC: 131546932(ehhadh)
PPRM: 120487255(ehhadh)
RKG: 130085777(ehhadh)
MAMB: 125270062(ehhadh)
CIDE: 127518238
MASI: 127447182
TROS: 130556176(ehhadh)
TDW: 130427882(ehhadh)
MANU: 129452342(ehhadh)
IPU: 108266325
IFU: 128608419(ehhadh)
PHYP: 113525435(ehhadh)
SMEO: 124382620(ehhadh)
TFD: 113636615(ehhadh)
TVC: 132850513(ehhadh)
AMEX: 103032907(ehhadh)
CMAO: 118811897(ehhadh)
EEE: 113574639(ehhadh)
CHAR: 105908680(ehhadh)
TRU: 101073728(ehhadh)
TFS: 130522172(ehhadh)
LCO: 104919050(ehhadh)
NCC: 104957955(ehhadh)
TBEN: 117485854(ehhadh)
CGOB: 115025945(ehhadh)
PGEO: 117466946(ehhadh)
GACU: 117556838(ehhadh)
ELY: 117251679(ehhadh)
EFO: 125899991(ehhadh)
PLEP: 121948720(ehhadh)
SLUC: 116049496(ehhadh)
ECRA: 117953467(ehhadh)
ESP: 116698260(ehhadh)
PFLV: 114563758(ehhadh)
GAT: 120833480(ehhadh)
PPUG: 119228649(ehhadh)
AFB: 129104453(ehhadh)
CLUM: 117750890(ehhadh)
MSAM: 119904012(ehhadh)
SCHU: 122885695(ehhadh)
CUD: 121522181(ehhadh)
ALAT: 119026408(ehhadh)
MZE: 101484421(ehhadh)
ONL: 100709434(ehhadh)
OAU: 116323006(ehhadh)
OLA: 101170799(ehhadh)
OML: 112155124(ehhadh)
XMA: 102219640(ehhadh)
XCO: 114148066(ehhadh)
XHE: 116722977(ehhadh)
PRET: 103461662(ehhadh)
PFOR: 103150606(ehhadh)
PLAI: 106963921(ehhadh)
PMEI: 106933048(ehhadh)
GAF: 122839879(ehhadh)
CVG: 107087127(ehhadh)
CTUL: 119771920(ehhadh)
GMU: 124871138(ehhadh)
NFU: 107390106(ehhadh)
KMR: 108240797(ehhadh)
ALIM: 106523328(ehhadh)
NWH: 119419099(ehhadh)
AOCE: 111588505(ehhadh)
MCEP: 125018015(ehhadh)
CSEM: 103392204(ehhadh)
POV: 109631473(ehhadh)
SSEN: 122765508(ehhadh)
HHIP: 117755359(ehhadh)
HSP: 118120384(ehhadh)
LCF: 108901033
SDU: 111218377(ehhadh)
SLAL: 111651262(ehhadh)
XGL: 120802001(ehhadh)
HCQ: 109523309(ehhadh)
SSCV: 125973324
SBIA: 133511792(ehhadh)
PEE: 133410933(ehhadh)
PTAO: 133486644(ehhadh)
BPEC: 110166609(ehhadh)
MALB: 109957167(ehhadh)
BSPL: 114847834(ehhadh)
SJO: 128367872(ehhadh)
SASA: 100195275(ehhadh)
STRU: 115155396(ehhadh)
OTW: 112218409(ehhadh)
OMY: 110501984(ehhadh)
OGO: 124035923(ehhadh)
ONE: 115121742(ehhadh)
OKI: 109882746(ehhadh)
OKE: 118386454(ehhadh)
SALP: 112072998(ehhadh)
CCLU: 121554858(ehhadh)
ELS: 105029884(ehhadh)
SFM: 108928073(ehhadh)
PKI: 111841633(ehhadh)
AANG: 118223161(ehhadh)
LOC: 102697242(ehhadh)
PSPA: 121323163(ehhadh)
ARUT: 117406299(ehhadh)
PSEX: 120531176(ehhadh)
LCM: 102356308(EHHADH)
LPIC: 129274156
APLC: 110973407
AJC: 117109929
PVUL: 126831728
PCAN: 112564830
BGT: 106068419
GAE: 121381196
HRF: 124135069
HRJ: 124258930
CVN: 111115883
CANU: 128163935
OED: 125665228
MYI: 110465017
PMAX: 117343813
MCAF: 127730470
RPHI: 132751977
DPOL: 127839426
LAK: 106165251
 » show all
Reference
PMID:8188243
  Authors
Hoefler G, Forstner M, McGuinness MC, Hulla W, Hiden M, Krisper P, Kenner L, Ried T, Lengauer C, Zechner R, et al.
  Title
cDNA cloning of the human peroxisomal enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme and localization to chromosome 3q26.3-3q28: a free left Alu Arm is inserted in the 3' noncoding region.
  Journal
Genomics 19:60-7 (1994)
DOI:10.1006/geno.1994.1013
  Sequence
[hsa:1962]
Reference
  Authors
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL
  Title
Regulation of cellular metabolism by protein lysine acetylation.
  Journal
Science 327:1000-4 (2010)
DOI:10.1126/science.1179689
LinkDB

DBGET integrated database retrieval system