KEGG ORTHOLOGY: K09848

ORTHOLOGY: K09848

Entry

K09848                      KO

Symbol

TRAF4

Name

TNF receptor-associated factor 4

Pathway

map04214

Apoptosis - fly

map04657

IL-17 signaling pathway

map05200

Pathways in cancer

map05222

Small cell lung cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09143 Cell growth and death
   04214 Apoptosis - fly
    K09848  TRAF4; TNF receptor-associated factor 4
09150 Organismal Systems
  09151 Immune system
   04657 IL-17 signaling pathway
    K09848  TRAF4; TNF receptor-associated factor 4
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K09848  TRAF4; TNF receptor-associated factor 4
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K09848  TRAF4; TNF receptor-associated factor 4

Genes

HSA:	9618(TRAF4)

PTR:	454534(TRAF4)

PPS:	100975513(TRAF4) 100980140

GGO:	101142858(TRAF4)

PON:	100431446(TRAF4)

NLE:	100607896(TRAF4)

HMH:	116470627 116474596(TRAF4)

MCC:	716364(TRAF4)

MCF:	102146475(TRAF4)

MTHB:

126938725 126956100

MNI:	105476400(TRAF4)

CSAB:

103242634(TRAF4)

CATY:

105591534(TRAF4)

PANU:

100998010(TRAF4) 101012840

TGE:	112609875(TRAF4)

MLEU:

105552020(TRAF4)

RRO:	104674107(TRAF4)

RBB:	108530161 108539936(TRAF4)

TFN:	117066115 117066440(TRAF4)

PTEH:

111520789(TRAF4)

CANG:

105510844(TRAF4)

CJC:	100404035(TRAF4)

SBQ:	101050448(TRAF4)

CIMI:

108313656(TRAF4)

CSYR:

103269140(TRAF4)

MMUR:

105857888(TRAF4)

LCAT:

123620262(TRAF4)

PCOQ:

105813515(TRAF4)

OGA:	100948546(TRAF4)

MMU:	22032(Traf4)

MCAL:

110305822(Traf4)

MPAH:

110331517(Traf4)

RNO:	303285(Traf4)

MCOC:

116078917(Traf4)

ANU:	117711719(Traf4)

MUN:	110544618(Traf4)

CGE:	100762863(Traf4)

MAUA:

101832293(Traf4)

PROB:

127218862(Traf4)

PLEU:

114691489(Traf4)

MORG:

121439731 121457042(Traf4)

MFOT:

126492289

AAMP:

119813293(Traf4)

NGI:	103730465(Traf4)

HGL:	101716536(Traf4)

CPOC:

100723177(Traf4)

CCAN:

109685873(Traf4)

DORD:

105985848(Traf4)

DSP:	122117999(Traf4)

PLOP:

125365843(Traf4)

NCAR:

124979915 124990203

MMMA:

107155151(Traf4)

OCU:

100344600

OPI:	101519553(TRAF4)

TUP:	102496823(TRAF4)

GVR:	103598599(TRAF4)

CFA:	100688511(TRAF4)

CLUD:

112677650(TRAF4)

VVP:	112933128(TRAF4)

VLG:	121473018(TRAF4)

NPO:	129517250(TRAF4)

AML:	100464464(TRAF4)

UMR:	103667407(TRAF4)

UAH:	113269047(TRAF4)

UAR:	123776940(TRAF4)

ELK:

111151781

LLV:

125087052

MPUF:

101680334(TRAF4)

MNP:	132004224(TRAF4)

MLK:	131816559(TRAF4)

NVS:	122906399(TRAF4)

ORO:	101366008(TRAF4)

EJU:	114214005(TRAF4)

ZCA:	113939327(TRAF4)

MLX:	118025276(TRAF4)

NSU:	110592964(TRAF4)

FCA:	101096365(TRAF4)

PYU:	121017224(TRAF4)

PCOO:

112855155(TRAF4)

PBG:	122485148(TRAF4)

PVIV:

125151850(TRAF4)

LRUF:

124512882

PTG:	102951157(TRAF4)

PPAD:

109251836(TRAF4)

PUC:

125926832

AJU:

106983231

HHV:	120246612(TRAF4)

BTA:	781568(TRAF4)

BOM:	102269869(TRAF4)

BIU:	109573194 109573977

BBUB:

102410311(TRAF4)

BBIS:

105003942(TRAF4)

CHX:	102169328(TRAF4)

OAS:	101107451(TRAF4)

BTAX:

128065129(TRAF4)

ODA:	120860780 120860782 120866282(TRAF4)

CCAD:

122448357(TRAF4)

MBEZ:

129540764(TRAF4)

SSC:	100518396(TRAF4)

CFR:	102507612(TRAF4)

CBAI:

105071559(TRAF4)

CDK:	105088169(TRAF4)

VPC:	102527080(TRAF4)

BACU:

103020623(TRAF4)

BMUS:

118886607(TRAF4)

LVE:	103082299(TRAF4)

OOR:	101273760(TRAF4)

DLE:	111185690(TRAF4)

PCAD:

102978993(TRAF4)

PSIU:

116745209(TRAF4)

NASI:

112394521(TRAF4)

ECB:	100072085(TRAF4)

EPZ:	103555959(TRAF4)

EAI:	106844533(TRAF4)

MYB:	102240047(TRAF4)

MYD:	102768459(TRAF4)

MMYO:

118671843(TRAF4)

MLF:	102432859(TRAF4)

PKL:	118702605(TRAF4)

EFUS:

103291725(TRAF4)

MNA:	107528737(TRAF4)

DRO:	112308504(TRAF4)

SHON:

119003465(TRAF4)

AJM:	119062023(TRAF4)

PDIC:

114503219(TRAF4)

PHAS:

123817690(TRAF4)

MMF:	118634970(TRAF4)

PPAM:

129070308(TRAF4)

HAI:	109385156(TRAF4)

RFQ:	117013039(TRAF4)

PALE:

102896659(TRAF4)

PGIG:

120620971(TRAF4)

PVP:	105291906(TRAF4)

RAY:	107507775(TRAF4)

MJV:	108383991(TRAF4)

TOD:	119232889(TRAF4)

SARA:

101551642(TRAF4)

SETR:

126008011(TRAF4)

LAV:	100660891(TRAF4)

TMU:

101356495

ETF:	101653562(TRAF4)

DNM:	101426030(TRAF4)

MDO:	100020121(TRAF4)

GAS:	123246797(TRAF4)

SHR:	100932711(TRAF4)

AFZ:

127558912

PCW:	110192193(TRAF4)

OAA:	100681634(TRAF4)

GGA:	417577(TRAF4)

PCOC:

116228054(TRAF4)

MGP:	100540312(TRAF4)

CJO:	107322689(TRAF4)

TPAI:

128083733(TRAF4)

LMUT:

125702971(TRAF4)

NMEL:

110407752(TRAF4)

APLA:

113845664(TRAF4)

ACYG:

106049412(TRAF4)

CATA:

118255094(TRAF4)

AFUL:

116497288(TRAF4)

TGU:	100227147(TRAF4)

LSR:	110482014(TRAF4)

SCAN:

103820296(TRAF4)

PMOA:

120507669(TRAF4)

OTC:	121345800(TRAF4)

PRUF:

121361845(TRAF4)

GFR:	102038680(TRAF4)

FAB:	101817428(NEK8)

OMA:	130260790(TRAF4)

PHI:	102112684(TRAF4)

PMAJ:

107212657(TRAF4)

CCAE:

111937949(TRAF4)

CCW:	120411032(TRAF4)

CBRC:

103616264(TRAF4)

ETL:	114061249(TRAF4)

ZAB:	102070669(TRAF4)

ACHL:

103810160(TRAF4)

SVG:	106853285(TRAF4)

MMEA:

130576979(TRAF4)

HRT:	120761329(TRAF4)

FPG:	101915588(TRAF4)

FCH:	102058322(TRAF4)

CLV:	102090831(TRAF4)

EGZ:	104131856(TRAF4)

NNI:	104012773(TRAF4)

ACUN:

113487313(TRAF4)

TALA:

116964432(TRAF4)

AFOR:

103898101(TRAF4)

ACHC:

115347565(TRAF4)

HLE:	104835588(TRAF4)

AGEN:

126039145

GCL:

127024467

CCRI:

104167363(TRAF4)

MUI:	104546588(TRAF4)

BREG:

104631890(TRAF4)

FGA:	104072933(TRAF4)

LDI:	104342273(TRAF4)

MNB:	103774124(TRAF4)

OHA:	104332828(TRAF4)

NNT:	104410839(TRAF4)

SHAB:

115601935(TRAF4)

DPUB:

104302772(TRAF4)

PGUU:

104460907(TRAF4)

ACAR:

104523560(TRAF4)

CPEA:

104397359(TRAF4)

AVIT:

104280272(TRAF4)

CVF:	104288432(TRAF4)

RTD:	128912933(TRAF4)

CUCA:

104058724(TRAF4)

AAM:	106487791(TRAF4)

AROW:

112960751(TRAF4)

NPD:	112954609(TRAF4)

DNE:	112986364(TRAF4)

ASN:	102371929(TRAF4)

AMJ:	102574069(TRAF4)

GGN:	109293374(TRAF4)

CMY:	102940376(TRAF4)

CCAY:

125624065(TRAF4)

DCC:	119844788(TRAF4)

CPIC:

101937641(TRAF4)

TST:	117867594(TRAF4)

CABI:

116829734(TRAF4)

MRV:	120387148(TRAF4)

ACS:

103278073

ASAO:

132763291(TRAF4)

PVT:	110084287(TRAF4)

SUND:

121916805(TRAF4)

PBI:	103063535(TRAF4)

PMUR:

107298393(TRAF4) 107300072

CTIG:

120318176(TRAF4)

TSR:	106551046(TRAF4)

PGUT:

117669809(TRAF4)

APRI:

131188588(TRAF4)

PTEX:

113454554(TRAF4)

VKO:	123023644(TRAF4)

PMUA:

114585136(TRAF4)

PRAF:

128402823(TRAF4)

ZVI:	118096944(TRAF4)

HCG:	128335989(TRAF4)

GJA:	107119394(TRAF4)

STOW:

125445930(TRAF4)

EMC:	129344505(TRAF4)

XLA:	446373(traf4.S) 447325(traf4.L)

XTR:	448646(traf4)

NPR:	108785865(TRAF4)

RTEM:

120927696(TRAF4)

BBUF:

120994672(TRAF4)

BGAR:

122930418(TRAF4)

MUO:	115456578(TRAF4)

GSH:	117349268(TRAF4)

DRE:	404035(traf4b) 404045(traf4a)

SRX:	107713157 107727926 107731960 107758738

SANH:

107661115 107661808 107672397 107704806

SGH:	107581928 107587295 107592758(traf4)

CCAR:

109077348 109083222 109083233

CAUA:

113038159 113058278 113070069 113115237

CGIB:

127941998 127972853 127985377 128029353

PTET:

122326953(traf4b) 122359056(traf4a)

LROH:

127152990(traf4b) 127177378(traf4a)

OMC:	131520788(traf4a) 131528444(traf4b)

PPRM:

120478815(traf4a) 120482998(traf4b)

RKG:	130077796(traf4a) 130095462(traf4b)

MAMB:

125248399(traf4a) 125252734(traf4b)

CIDE:

127494946 127503157

MASI:

127422495 127429188 127429564 127431274

TROS:

130564886(traf4a) 130569698

TDW:	130408455(traf4b) 130429234(traf4a)

MANU:

129423426(traf4b) 129437810(traf4a)

IPU:	108277967(traf4a) 108279198(traf4b)

IFU:	128621253(traf4a) 128621970(traf4b)

PHYP:

113532979(traf4) 113541461

SMEO:

124394955(traf4a) 124398202(traf4b)

TFD:	113636744(traf4a) 113662491(traf4b)

TVC:	132857675(traf4a) 132859791 132860302(traf4b)

AMEX:

103024022(traf4) 103043275

CMAO:

118799430(traf4a) 118820422(traf4b)

EEE:	113583143 113587652

CHAR:

105911029(traf4a)

TRU:	101079223(traf4)

TFS:	130534935(traf4a)

TNG:	GSTEN00030113G001

LCO:	104933840(traf4)

NCC:	104947740(traf4)

TBEN:

117468749(traf4a)

CGOB:

115018135(traf4)

PGEO:

117457740(traf4a)

GACU:

117540389(traf4a)

EMAC:

134880577(traf4a)

ELY:	117260233(traf4a)

EFO:	125888377(traf4a)

PLEP:

121943609(traf4a)

SLUC:

116048463(traf4a)

ECRA:

117942064(traf4a)

ESP:	116683162(traf4)

PFLV:

114553312(traf4)

GAT:	120821517(traf4a)

PPUG:

119211579(traf4a)

AFB:	129092181(traf4a)

CLUM:

117741943(traf4a)

PSWI:

130210966(traf4a)

MSAM:

119882582(traf4a)

SCHU:

122878428(traf4a)

CUD:	121524632(traf4a)

ALAT:

119010092(traf4a)

MZE:	101478516(traf4)

ONL:	100692866(traf4)

OAU:	116313869(traf4a)

OLA:	101161428(traf4)

OML:	112149230(traf4a)

CSAI:

133441890(traf4a)

XMA:	102237563(traf4)

XCO:	114161854(traf4)

XHE:	116737494(traf4)

PRET:

103474150(traf4)

PFOR:

103148535(traf4)

PLAI:

106963640(traf4)

PMEI:

106932491(traf4)

GAF:	122832115(traf4a)

PPRL:

129369758(traf4a)

CVG:	107090393(traf4)

CTUL:

119795376(traf4a)

GMU:	124883834(traf4a)

NFU:	107379986(traf4)

KMR:	108247288(traf4a)

ALIM:

106528834(traf4)

NWH:	119410703(traf4a)

AOCE:

111580070(traf4)

MCEP:

125013546(traf4a)

CSEM:

103378251(traf4)

POV:	109630346(traf4)

SSEN:

122773556(traf4a)

HHIP:

117772930(traf4a)

HSP:	118106284(traf4a)

SMAU:

118299219(traf4a)

LCF:	108876091(traf4a)

SDU:	111232339(traf4)

SLAL:

111649109(traf4)

XGL:	120791554(traf4a)

HCQ:	109514842(traf4)

SSCV:

125972663

SBIA:

133504965(traf4a)

PEE:	133404850(traf4a)

PTAO:

133482010(traf4a)

BPEC:

110163593(traf4)

MALB:

109972100(traf4)

BSPL:

114867697(traf4a)

SJO:	128360744(traf4a)

SASA:

100380313(traf4) 106581191

STRU:

115163415 115206330

OTW:	112265512 112267086(traf4a)

OMY:	110503912 110507756

OGO:	123992749 124005598(traf4a)

ONE:	115136758 115141822

OKI:	109905702 109909115

OKE:	118365170 118397446

SALP:

111982841 112080492

SNH:	120018197 120028865

CCLU:

121560176 121567953

ELS:	105024873(traf4)

SFM:	108921171 108932080

PKI:	111833059 111847189

AANG:

118236618

LOC:	102689292(traf4)

PSPA:

121306730 121308777(traf4a)

ARUT:

117429503 117430603

PSEX:

120530664

LCM:	102365594(TRAF4)

CMK:

RTP:

CPLA:

HOC:

LERI:

129710886(traf4a)

PMRN:

116936827(TRAF4)

BFO:	118421511 118426241 118426474 118432803

BBEL:

109467762 109468226

CIN:	100169997(zf(traf/ring)-2) 100178442 778947(zf(traf/ring)-1)

SCLV:

120330737 120345475

SPU:	115926879 574808 587392

LPIC:

129254575 129254597

APLC:

110986291 110987009

AJC:

117118417

SKO:	100313755 100375043

DME:	Dmel_CG3048(Traf4)

DER:

6541238

DSI:	Dsimw501_GD23279(Dsim_GD23279)

DYA:	Dyak_GE18283(Dyak_Traf1)

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI22040

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ005312

CPII:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:	114879516 114879522

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209601

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105380927 105393322

PGW:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:	128987444 129004941

PHU:	Phum_PHUM275010

FOC:

ZNE:

CSEC:

SGRE:

BROR:

IEL:

DPX:	DAPPUDRAFT_51929

DMK:

116917410

DPZ:

124314718

EAF:	111708678 111716930

LSM:

TCF:

PPOI:

ISC:

DSV:	119431945 119446169

RSAN:

119371959 119389992 119394603 119407298

RMP:	119164263 119172610 119174407

VDE:	111246580 111250120 111253539

VJA:	111259477 111262088 111265961 111267362

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

106459342 106462564 106463753 106465076 106468754

CEL:	CELE_F45G2.6(trf-1) CELE_Y110A7A.2(trf-2)

CBR:	CBG_21219(Cbr-trf-1) CBG_23748

CRQ:	GCK72_000353 GCK72_008385

NAI:	NECAME_01384 NECAME_15413

HRO:	HELRODRAFT_175057

PCAN:

112562574

BGT:	106057139 106080042

GAE:	121368340 121379071

HRF:

124135183

HRJ:

124273421

CRG:	105347139 105348784 117692576

CVN:	111135695 111137374

CANU:

128188911 128189023

OED:	125670024 125680844

MYI:	110458603 110466008

PMAX:

117332515 117333642

MCAF:

127711783

MMER:

123533781 123534774 123563071

RPHI:

132742419 132749660 132758968

DPOL:

127856322 127863698

OBI:

106871852

OSN:

115224855

LAK:	106151227 106181010 112042501

SMM:	Smp_168390 Smp_196450

SHX:	MS3_00003647(TRAF4_2)

OVI:	T265_04245

EGL:

EGR_10095

NVE:	5501009 5502622 5502624 5503999 5504001 5509293 5512371 5517997 5521731

EPA:	110231324 110231492 110231578 110231579 110233418 110233952 110235585 110237537 110238632 110239272 110239518 110242907 110244250 110252214 110252240 110252241 110252300 110252398 110253155

ATEN:

116286426 116286745 116286985 116286986 116287628 116288424 116288894 116289566 116291689 116301755 116304207

ADF:	107328755 107335878 107337998 107341963 107346065 107346138 107355935 107355936 107355937 107355938 107356677 107358281 107358283 107358294 107358505

AMIL:

114948680 114949411 114954444 114954548 114954549 114954550 114955477 114956400 114956401 114956447 114957874 114958565 114958853 114966349 114970930 114971164

PDAM:

113664861 113665769 113665771 113669608 113669617 113669780 113672934 113673024 113673104 113677326 113678044 113683296 113684425 113684441 113684530 113685114 113685898 113686127

DGT:	114516494 114517571 114517573 114517582 114517628 114519440 114520267 114523649 114523783 114524005 114524006 114527835 114528282 114536377 114544038

XEN:	124436052 124436630 124441390 124441790 124442707 124445410 124453057

HMG:	100197701 100201887 100205980 100206491 100207212 100212853 101234475

HSY:	130621817 130622060 130623645 130623889 130629852 130635541 130635941 130656477 130657149

TAD:	TRIADDRAFT_26989 TRIADDRAFT_27129

OLU:	OSTLU_89070

OTA:	OT_ostta15g00590

MIS:	MICPUN_64643

MPP:	MICPUCDRAFT_63642(JGI:MicpuC2_63642)

DDI:	DDB_G0272340

DPP:	DICPUDRAFT_37582

TET:	TTHERM_00378820

» show all

Reference

PMID:7490069

Authors

Tomasetto C, Regnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC

Title

Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.

Journal

Genomics 28:367-76 (1995)
DOI:10.1006/geno.1995.1163

Sequence

[hsa:9618]

Reference

PMID:12023963

Authors

Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS

Title

Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase.

Journal

J Biol Chem 277:28051-7 (2002)
DOI:10.1074/jbc.M202665200

Sequence

[hsa:9618]

LinkDB

DBGET integrated database retrieval system