KEGG ORTHOLOGY: K10085

ORTHOLOGY: K10085

Entry

K10085                      KO

Symbol

EDEM2

Name

ER degradation enhancer, mannosidase alpha-like 2

Pathway

map04141

Protein processing in endoplasmic reticulum

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K10085  EDEM2; ER degradation enhancer, mannosidase alpha-like 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04091 Lectins
    K10085  EDEM2; ER degradation enhancer, mannosidase alpha-like 2
Lectins [BR:ko04091]
M-type lectins
  K10085  EDEM2; ER degradation enhancer, mannosidase alpha-like 2

Genes

HSA:	111089941(MMP24-AS1-EDEM2) 55741(EDEM2)

PTR:	458197(EDEM2)

PPS:	100980744(EDEM2)

GGO:	101130517(EDEM2)

PON:	100174723(EDEM2)

PPYG:

129021419(EDEM2)

NLE:

100606026

HMH:	116460948(EDEM2)

SSYN:

129474850(EDEM2)

MCC:	706150(EDEM2)

MCF:	101864833(EDEM2)

MTHB:

126964205

MNI:	105496255(EDEM2)

CSAB:

103248949

CATY:

105582310(EDEM2)

PANU:

101016705(EDEM2)

TGE:	112633031(EDEM2)

MLEU:

105533845(EDEM2)

RRO:	104680522(EDEM2)

RBB:	108534646(EDEM2)

TFN:	117068689(EDEM2)

PTEH:

111548173(EDEM2)

CANG:

105502612(EDEM2)

CJC:	100395668(EDEM2)

SBQ:	101045376(EDEM2)

CIMI:

108292582(EDEM2)

ANAN:

105719196(EDEM2)

CSYR:

103272795(EDEM2)

MMUR:

105866031(EDEM2)

LCAT:

123622405(EDEM2)

PCOQ:

105804910(EDEM2)

OGA:	100961420(EDEM2)

MMU:	108687(Edem2)

MCAL:

110310781

MPAH:

110317724(Edem2)

RNO:	296304(Edem2)

MCOC:

116091245(Edem2)

ANU:

117704310

MUN:	110550571(Edem2)

CGE:

100753801

MAUA:

101829566(Edem2)

PROB:

127227979

PLEU:

114706521

MORG:

121460215(Edem2)

MFOT:

126506977

AAMP:

119814421(Edem2)

NGI:	103728471(Edem2)

HGL:	101700166(Edem2)

CPOC:

100714018(Edem2)

CCAN:

109695335(Edem2)

DORD:

105981500(Edem2)

DSP:

122120278

PLOP:

125353408(Edem2)

NCAR:

124977789

MMMA:

107138686(Edem2)

OCU:

100344900

OPI:

101528946

TUP:	102499834(EDEM2)

GVR:	103590769(EDEM2)

CFA:	477209(EDEM2)

CLUD:

112673858(EDEM2)

VVP:

112928221

VLG:	121478208(EDEM2)

NPO:	129494801(EDEM2)

AML:	100482741(EDEM2)

UMR:

103669810

UAH:	113258529(EDEM2)

UAR:	123798036(EDEM2)

ELK:

111141658

LLV:

125109250

MPUF:

101670584(EDEM2)

MNP:	132021862(EDEM2)

MLK:	131807799(EDEM2)

NVS:

122916130

ORO:	101376181(EDEM2)

EJU:	114220601(EDEM2)

ZCA:	113937285(EDEM2)

MLX:

118011413

NSU:

110579390

LWW:	102725854(EDEM2)

FCA:	101083162(EDEM2)

PYU:	121012270(EDEM2)

PCOO:

112868785

PBG:	122497530(EDEM2)

PVIV:

125161749(EDEM2)

LRUF:

124503048

PTG:	102969307(EDEM2)

PPAD:

109272519(EDEM2)

PUC:

125936678

AJU:

106973958

HHV:	120242793(EDEM2)

BTA:	513253(EDEM2)

BOM:	102287255(EDEM2)

BIU:	109567395(EDEM2)

BBUB:

102396723(EDEM2)

BBIS:

104999340(EDEM2)

CHX:	102170888(EDEM2)

OAS:	101115389(EDEM2)

BTAX:

128058475(EDEM2)

CSUM:

138091441(EDEM2)

ODA:	120868678(EDEM2)

CCAD:

122448282

MREE:

136159537(EDEM2)

MBEZ:

129562812(EDEM2)

SSC:	100621927(EDEM2)

CFR:

102508945

CBAI:

105073530(EDEM2)

CDK:	105084960(EDEM2)

VPC:	102538732(EDEM2)

BACU:

102997949(EDEM2)

BMUS:

118881738(EDEM2)

LVE:	103086214(EDEM2)

OOR:	101283160(EDEM2)

DLE:	111184240(EDEM2)

PCAD:

129391321(EDEM2)

PSIU:

116740665(EDEM2)

NASI:

112398392

ECB:	100054608(EDEM2)

EPZ:	103554429(EDEM2)

EAI:

106837271

MYB:	102240890(EDEM2)

MYD:	102762548(EDEM2)

MMYO:

118663539

MLF:	102434914(EDEM2)

MDT:	132239556(EDEM2)

PKL:	118707349(EDEM2)

EFUS:

103293348(EDEM2)

MNA:	107537205(EDEM2)

DRO:

112303840

SHON:

118985406

AJM:	119063301(EDEM2)

PDIC:

114506646

PHAS:

123815351(EDEM2)

MMF:

118619301

PPAM:

129070746(EDEM2)

HAI:	109389624(EDEM2)

RFQ:	117015913(EDEM2)

PALE:

102879027

PGIG:

120603582

PVP:	105304303(EDEM2)

RAY:	107500804(EDEM2)

MJV:	108406327(EDEM2)

SARA:

101546123(EDEM2)

SETR:

126017325(EDEM2)

LAV:	100667220(EDEM2)

TMU:

101353212

ETF:	101657879(EDEM2)

DNM:	101439105(EDEM2)

MDO:	100032432(EDEM2)

GAS:	123237442(EDEM2)

SHR:

100930044

AFZ:

127550352

PCW:	110216762(EDEM2)

TVP:

118844298

PBRV:

138153569(EDEM2)

OAA:	100080350(EDEM2)

GGA:	770034(EDEM2)

PCOC:

116235138

MGP:

100543429

CJO:

107322864

TPAI:

128081032(EDEM2)

LMUT:

125701257(EDEM2)

NMEL:

110408248(EDEM2)

APLA:

101789577

ACYG:

106047756(EDEM2)

CATA:

118248909(EDEM2)

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:	102038524(EDEM2)

FAB:	101815810(EDEM2)

OMA:	130261145(EDEM2)

PHI:	102113088(EDEM2)

PMAJ:

107213166

CCAE:

111938321(EDEM2)

CCW:

104687899

CBRC:

103616232(EDEM2)

ACOE:

138120841(EDEM2)

ETL:

114057272

ZAB:

102061666

ZLE:	135456273(EDEM2)

ACHL:

103798125(EDEM2)

SVG:	106853081(EDEM2)

MMEA:

130583567(EDEM2)

HRT:	120760215(EDEM2)

SATI:

136368386(EDEM2)

FPG:	101922573(EDEM2)

FCH:

102051892

CCRI:

104154886(EDEM2)

NNT:	104399336(EDEM2)

SHAB:

ACUN:

TALA:

ACHC:

HALD:

104310972(EDEM2)

HLE:	104842000(EDEM2)

AGEN:

126045849

HHAR:

128143086(EDEM2)

GCL:

127023238

CSTI:

104553900(EDEM2)

LDI:	104339917(EDEM2)

MNB:	103769012(EDEM2)

DPUB:

104303866(EDEM2)

PPUS:

135188254(EDEM2)

AVIT:

104273714(EDEM2)

BRHI:

104488087(EDEM2)

EGZ:	104124993(EDEM2)

NNI:	104019981(EDEM2)

PCRI:

104024752(EDEM2)

PCAO:

104044216(EDEM2)

PADL:

103912427(EDEM2)

AFOR:

103903393(EDEM2)

FGA:	104073672(EDEM2)

GSTE:

104250587(EDEM2)

CLV:	102087993(EDEM2)

MUI:	104533562(EDEM2)

PGUU:

104458156(EDEM2)

PLET:

104619263(EDEM2)

EHS:	104516752(EDEM2)

CMAC:

104476896(EDEM2)

CUCA:

104063258(EDEM2)

TEO:	104370045(EDEM2)

BREG:

104634680(EDEM2)

OHA:	104338346(EDEM2)

ACAR:

104523135

CPEA:

104389394(EDEM2)

CVF:	104292678(EDEM2)

RTD:	128916658(EDEM2)

AAM:	106490120(EDEM2)

AROW:

112971423

NPD:

112949608

TGT:	104580439(EDEM2)

DNE:

112983787

SCAM:

104146449(EDEM2)

ASN:

102378524

AMJ:	102570218(EDEM2)

CPOO:

109313216(EDEM2)

GGN:	109294588(EDEM2)

PSS:

102459056

CMY:

102943251

CCAY:

125622576(EDEM2)

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:	100561439(edem2)

ASAO:

132773254(EDEM2)

PVT:	110073344(EDEM2)

SUND:

PBI:

PMUR:

CTIG:

TSR:	106543096(EDEM2)

PGUT:

117663692(EDEM2)

APRI:

131196202(EDEM2)

PTEX:

NSS:

VKO:

PMUA:

PRAF:

128416311(EDEM2)

ZVI:

118089064

HCG:	128323678(EDEM2)

GJA:	107122212(EDEM2)

STOW:

125433564(EDEM2)

EMC:	129330723(EDEM2)

XLA:	108701068(edem2.L)

XTR:	448548(edem2)

NPR:	108797481(EDEM2)

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	402801(edem2)

SRX:	107705666 107723131(edem2)

SANH:

107697010

SGH:	107601347(edem2)

CCAR:

109054834

CAUA:

113041053 113070284

CGIB:

127944465 128012052

PTET:

122329276(edem2)

LROH:

127155257(edem2)

OMC:	131532658(edem2)

PPRM:

120478160(edem2)

RKG:	130070797(edem2)

MAMB:

125259983(edem2)

CIDE:

127504645

CERY:

137009355(edem2)

MASI:

127419233

TROS:

130545597(edem2)

TDW:	130409753(edem2)

MANU:

129431241(edem2)

IPU:

108276291

IFU:	128619370(edem2)

PHYP:

113530600

TFD:	113641721(edem2)

TVC:	132861943(edem2)

TRN:	134333321(edem2)

AMEX:

103022382(edem2)

CMAO:

118822027(edem2)

EEE:

113583115

CHAR:

105906442(edem2)

TRU:

101062875

TFS:	130530321(edem2)

TNG:	GSTEN00023343G001

LCO:

104938156

TBEN:

117478537(edem2)

CGOB:

115010560

PGEO:

117449137(edem2)

GACU:

117536258(edem2)

EMAC:

134872187(edem2)

ELY:	117258535(edem2)

EFO:	125891216(edem2)

SLUC:

116037467(edem2)

ESP:

116685430

PFLV:

114558615

GAT:	120828957(edem2)

PPUG:

119223325(edem2)

AFB:	129100104(edem2)

CLUM:

117733043(edem2)

PSWI:

130200189(edem2)

CANA:

137800438(edem2)

CVE:	137888696(edem2)

MSAM:

119905988(edem2)

CUD:	121517010(edem2)

ALAT:

119022465(edem2)

ASTR:

137609151(edem2)

MZE:

101476421

ONL:

100709064

OAU:	116328416(edem2)

OLA:	101162666(edem2)

OML:	112159771(edem2)

CSAI:

133456318(edem2)

XMA:	102227646(edem2)

XCO:

114141103

XHE:

116722945

PRET:

103460635(edem2)

PFOR:

103156225(edem2)

PLAI:

106943133(edem2)

PMEI:

106910399(edem2)

GAF:	122837675(edem2)

PPRL:

129354437

CVG:	107105183(edem2)

CTUL:

119778912(edem2)

GMU:	124872578(edem2)

NFU:	107391491(edem2)

ALIM:

106531972(edem2)

AOCE:

111562423(edem2)

EJA:	138215563(edem2)

MCEP:

125009077(edem2)

CSEM:

103384448(edem2)

POV:	109641689(edem2)

SSEN:

122777632(edem2)

HHIP:

117765258(edem2)

HSP:	118110362(edem2)

PPLT:

128443130(edem2)

SMAU:

118316643(edem2)

LCF:	108876357 108892159

SDU:	111237648(edem2)

SLAL:

111673359(edem2)

XGL:	120804257(edem2)

HCQ:	109526471(edem2)

SSCV:

125988681(edem2)

SBIA:

133493361(edem2)

PEE:	133411572(edem2)

PTAO:

133473507(edem2)

BPEC:

110157998(edem2)

MALB:

109968596(edem2)

BSPL:

114859256(edem2)

SJO:	128356898(edem2)

SASA:

106572079(edem2)

STRU:

115165953

OTW:	112216024(edem2)

OMY:	110532295(edem2)

OGO:	124022040(edem2)

ONE:

115132171

OKI:

109908006

OKE:	118375216(edem2)

SALP:

111966459(edem2)

SNH:	120059331(edem2)

CCLU:

121538354(edem2)

ELS:

105022996

SFM:

108936922

PKI:	111837011(edem2)

AANG:

118208712(edem2)

LOC:	102683884(edem2)

PSPA:

121316616 121319335(edem2)

ARUT:

117424463 117433284

PSEX:

120514779(edem2)

LCM:	102367625(EDEM2)

CMK:	103189915(edem2)

RTP:

109910942

CPLA:

122560260(edem2)

HOC:	132822795(edem2)

LERI:

129707284(edem2)

PMRN:

116952059

LRJ:	133354954(EDEM2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG3810(Edem1)

DER:

6555655

DSE:

6616054

DSI:	Dsimw501_GD16401(Dsim_GD16401)

DYA:	Dyak_GE16995

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21757

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108376188 108378644

AOQ:

129238487

TDA:	119670321 119671479

MDE:	101901457 131807055

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ012733

CPII:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105673559(Edem1)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124218288(Edem1)

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_205662

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137928694(Edem1)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:	100167725 100572274

DNX:

107168053

AGS:

114132954

RMD:	113556192 113556802

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106690654(Edem1)

NLU:

111047036

HVI:

124362337

MQU:	128990333 128990562

PHU:	Phum_PHUM377490

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:	124162212 124163102

FCD:

110854427

DPX:	DAPPUDRAFT_272847 DAPPUDRAFT_305234

DMK:

DPZ:

AFRA:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123773734(Edem1)

CQD:

PTRU:

ESN:

MNZ:

MRJ:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F10C2.5(F10C2.5)

CBR:

CBG_23361

CRQ:	GCK72_018172

BMY:	BM_BM3259(Bm3259)

LOA:	LOAG_01645 LOAG_16558

TSP:

Tsp_01979

HRO:	HELRODRAFT_194877

LGI:	LOTGIDRAFT_223717

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

HASI:

CRG:

CANU:

CVN:	111100967 111102428

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:	106874461 106878781

OSN:

115214236

LJP:

135466492

LAK:

106152880

SMM:	Smp_143170

SHX:	MS3_00007936(EDEM2_2)

OVI:	T265_01329

EGL:

LLON:

NVE:

EPA:

ATEN:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_52514

AQU:

ATH:

ALY:

CRB:

CSAT:

104725087 104728623 104760586

EUS:	EUTSA_v10003168mg

BRP:

103848826

BNA:	106381573 106411464

BOE:

RSZ:

THJ:

CPAP:

CIT:

CIC:	CICLE_v10004553mg

PVY:

MINC:

TCC:

GRA:

GHI:	107928579 107929165

GAB:

HSYR:

DZI:

EGR:

GMX:

GSJ:

PVU:

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:	131644277 131644282

LJA:

130717584

ADU:

107466139

AIP:

107617978

AHF:	112711181 112775892

LANG:

109336475

PCIN:

129320176

QSA:	O6P43_003290

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

111785090 111785386 111801113

RCU:

MEAN:

JCU:

HBR:

MESC:

POP:

PEU:	105127789 105129498

PALZ:

PNZ:

JRE:

CILL:

CAVE:

AGLU:

QSU:

QLO:

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107771256 107806991 107810093 107815521

NSY:

104214654

NTO:	104094314 104103030

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110704792 110707508

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

OBR:

OGL:

BDI:

ATS:	109776866 109786606

TDC:	119269171 119277168

TAES:

123062213 123070958 123079340

TUA:

LPER:

LRD:

SBI:

ZMA:

MFLO:

SITA:

SVS:

PVIR:

PHAI:

PAUA:

PDA:

EGU:

MUS:

ZOF:	121979380 121984006

DCT:

PEQ:

AOF:

MSIN:

ACAK:

NCOL:

ATR:

CJF:

SMO:	SELMODRAFT_121761 SELMODRAFT_92622

PPP:

112294749

VCN:	VOLCADRAFT_59905

CVR:	CHLNCDRAFT_7049

OLU:	OSTLU_1860

OTA:	OT_ostta10g02940

GSL:	Gasu_52030

CCP:	CHC_T00008848001

MBR:	MONBRDRAFT_33664

SRE:	PTSG_12582

DDI:	DDB_G0277051

DPP:	DICPUDRAFT_91147

DFA:

DFA_06064

ACAN:

ACA1_061090

PTI:	PHATRDRAFT_52346

FCY:	FRACYDRAFT_189169(MNS3_1)

TPS:	THAPSDRAFT_30950

AAF:	AURANDRAFT_30199

PIF:	PITG_02266

PSOJ:

PHYSODRAFT_310282

SPAR:

SPRG_01028

TCR:

508317.80

NGR:	NAEGRDRAFT_67921

EHX:	EMIHUDRAFT_235221 EMIHUDRAFT_237798 EMIHUDRAFT_237799

GTT:	GUITHDRAFT_157285 GUITHDRAFT_157889 GUITHDRAFT_64693

LSOL:

GOY17_01555

LARE:

HIV01_012395

THES:

FHQ07_13300

TCN:	H9L16_15795

XBC:	ELE36_10610

WIN:

WPG_1800

TJE:	TJEJU_1115

GAA:	HX109_10145

CABY:

Cabys_2665

» show all

Reference

PMID:15537790

Authors

Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW

Title

Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins.

Journal

Glycobiology 15:421-36 (2005)
DOI:10.1093/glycob/cwi014

Sequence

[hsa:55741]

LinkDB

DBGET integrated database retrieval system