KEGG ORTHOLOGY: K12743

ORTHOLOGY: K12743

Entry

K12743                      KO

Symbol

PCBAB

Name

N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase [EC:6.3.2.26]

Pathway

map00311

Penicillin and cephalosporin biosynthesis

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00672

Penicillin biosynthesis, aminoadipate + cycteine + valine => penicillin

M00673

Cephamycin C biosynthesis, aminoadipate + cycteine + valine => cephamycin C

Reaction

R04870

L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming, valine-inverting)

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00311 Penicillin and cephalosporin biosynthesis
    K12743  PCBAB; N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K12743  PCBAB; N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Enzymes [BR:ko01000]
6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.26  N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
     K12743  PCBAB; N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
Polyketide biosynthesis proteins [BR:ko01008]
Nonribosomal peptide synthetase (NRPS)
  Linear NRPS
   ACV synthetase
    K12743  PCBAB; N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase

Other DBs

GO:

0050564

Genes

BCOO:

119075341

PMEO:

129593796 129595266

PCHM:

VFPPC_08658

ANI:	ANIA_02621

AOR:	AO090038000543

AFV:	AFLA_009029

APUU:

APUU_12364S

ABE:

ARB_02226

TVE:

TRV_00553

XRY:	QN244_11740

SCLF:

BB341_07790

STIR:

DDW44_23095

SCT:	SCAT_5684(pcbAB)

SCY:	SCATT_56840

AAB:	A4R43_03220

AMYY:

YIM_39185(srfAA)

PSUU:

Psuf_059700

» show all

Reference

PMID:2061333

Authors

MacCabe AP, van Liempt H, Palissa H, Unkles SE, Riach MB, Pfeifer E, von Dohren H, Kinghorn JR

Title

Delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Aspergillus nidulans. Molecular characterization of the acvA gene encoding the first enzyme of the penicillin biosynthetic pathway.

Journal

J Biol Chem 266:12646-54 (1991)
DOI:10.1016/S0021-9258(18)98948-9

Sequence

[ani:ANIA_02621]

LinkDB

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