KEGG ORTHOLOGY: K14959

ORTHOLOGY: K14959

Entry

K14959                      KO

Symbol

MLL4

Name

[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00773

Autosomal dominant intellectual developmental disorder

H00831

Primary dystonia

H01613

Follicular lymphoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
   03036 Chromosome and associated proteins
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
   HMT complexes
    MLL3/MLL4 complex
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4

Other DBs

GO:

0042800

Genes

HSA:	9757(KMT2B)

PTR:	455959(KMT2B)

PPS:	100979249(KMT2B)

GGO:	101139923(KMT2B)

PON:	100442005(KMT2B)

PPYG:

129019515(KMT2B)

NLE:	100594433(KMT2B)

HMH:	116478917(KMT2B)

SSYN:

129459631(KMT2B)

MCC:	718835(KMT2B)

MCF:	102115861(KMT2B)

MTHB:

126941879

MNI:	105495504(KMT2B)

CSAB:

103234531(KMT2B)

CATY:

105578189(KMT2B)

PANU:

101011413(KMT2B)

TGE:	112613055(KMT2B)

MLEU:

105543104(KMT2B)

RRO:	104667085(KMT2B)

RBB:	108512323(KMT2B)

TFN:	117092369(KMT2B)

PTEH:

111529937(KMT2B)

CANG:

105516695(KMT2B)

CJC:	100407541(KMT2B)

SBQ:	101034359(KMT2B)

CIMI:

108286344(KMT2B)

ANAN:

105707046(KMT2B)

CSYR:

103249681(KMT2B)

MMUR:

105876915(KMT2B)

LCAT:

123624459(KMT2B)

PCOQ:

105816259(KMT2B)

OGA:	100941061(KMT2B)

MMU:	75410(Kmt2b)

MCAL:

110297666(Kmt2b)

MPAH:

110338314(Kmt2b)

RNO:	102550344(Kmt2b)

MCOC:

116101986(Kmt2b)

ANU:	117709080(Kmt2b)

ASYL:

127671532(Kmt2b)

MUN:	110550986(Kmt2b)

CGE:	100750575(Kmt2b)

MAUA:

101835352(Kmt2b)

PROB:

127238764(Kmt2b)

PLEU:

114681635(Kmt2b)

MORG:

121449315(Kmt2b)

MFOT:

126486716

AAMP:

119820602(Kmt2b)

NGI:	103729965(Kmt2b)

HGL:	101699273(Kmt2b)

CPOC:

100735175(Kmt2b)

CCAN:

109689598(Kmt2b)

DORD:

105993122(Kmt2b)

DSP:	122097464(Kmt2b)

DMER:

138811088(Kmt2b)

PLOP:

125368349(Kmt2b)

NCAR:

124966333

MMMA:

107151676(Kmt2b)

ITI:	101962874(Kmt2b)

OCU:

100353483

OPI:	101535318(KMT2B)

TUP:	102477772(KMT2B)

GVR:	103583372 103592831(KMT2B)

CFA:	100688666(KMT2B)

CLUD:

112643518(KMT2B)

VVP:	112928324(KMT2B)

VLG:	121484255(KMT2B)

NPO:	129499888(KMT2B)

AML:	100469094(KMT2B)

UMR:	103682560(KMT2B)

UAH:	113244759(KMT2B)

UAR:	123793892(KMT2B)

ELK:

111161417

LLV:

125088364

MPUF:

101685930(KMT2B)

MNP:	132005509(KMT2B)

MLK:	131818658(KMT2B)

NVS:	122911561(KMT2B)

ORO:	101370290(KMT2B)

EJU:	114224359(KMT2B)

ZCA:	113935548(KMT2B)

MLX:	118022788(KMT2B)

NSU:	110590086(KMT2B)

LWW:	102730782(KMT2B)

FCA:	101098760(KMT2B)

PYU:	121011346(KMT2B)

PCOO:

112851004(KMT2B)

PBG:	122495065(KMT2B)

PVIV:

125153519(KMT2B)

LRUF:

124511218

LGF:	123578205(KMT2B)

AJU:

106974745

PTG:	102964982(KMT2B)

PPAD:

109251503(KMT2B)

PUC:	125918291 125918297

PLEZ:

122208268(KMT2B)

HHV:	120243477(KMT2B)

BTA:	785776(KMT2B)

BOM:	102269320(KMT2B)

BIU:	109572325(KMT2B)

BBIS:

104995419(KMT2B)

CHX:	102172292(KMT2B)

OAS:	101104086(KMT2B)

BTAX:

128062799(KMT2B)

CSUM:

138096646(KMT2B)

ODA:	120872497(KMT2B)

CCAD:

122421375(KMT2B)

MREE:

136161181(KMT2B)

OVR:	110123621(KMT2B)

MBEZ:

129546059(KMT2B)

SSC:	100520742(KMT2B)

CFR:	102520520(KMT2B)

CBAI:

105065102(KMT2B)

CDK:

105088051

VPC:	102538562(KMT2B)

BACU:

103015601(KMT2B)

BMUS:

118884797(KMT2B)

LVE:	103073652(KMT2B)

OOR:	101276223(KMT2B)

LALB:

132509963(KMT2B)

GMF:	115862579(KMT2B)

DDP:	132416107(KMT2B)

DLE:	111181136(KMT2B)

PCAD:

102987727(KMT2B)

PSIU:

116744553(KMT2B)

PPHC:

136141197(KMT2B)

NASI:

112392388(KMT2B)

ECB:	100059802(KMT2B)

EPZ:	103566091(KMT2B)

EAI:	106829152(KMT2B)

MYB:	102259087(KMT2B)

MYD:	102771251(KMT2B)

MMYO:

118674717(KMT2B)

MLF:	102433699(KMT2B)

MDT:	132216977(KMT2B)

MYUM:

138997216(KMT2B)

PKL:	118720655(KMT2B)

EFUS:

103284776(KMT2B)

MNA:	107543372(KMT2B)

DRO:	112320053(KMT2B)

SHON:

118982549(KMT2B)

AJM:	119044204(KMT2B)

PDIC:

114511083(KMT2B)

PHAS:

123823661(KMT2B)

MMF:	118638673(KMT2B)

PPAM:

129083195(KMT2B)

HAI:	109372008(KMT2B)

RFQ:	117034916(KMT2B)

PALE:

102881431(KMT2B)

PGIG:

120592489(KMT2B)

PVP:	105306647(KMT2B)

RAY:	107497624(KMT2B)

MJV:	108401519(KMT2B)

TOD:	119250148(KMT2B)

SARA:

101537418(KMT2B)

SFUM:

130044014(KMT2B)

SETR:

126027579(KMT2B)

LAV:	100669611(KMT2B)

TMU:

101345928

ETF:	101656752(KMT2B)

DNM:	101413650(KMT2B)

MDO:	100617561(KMT2B)

GAS:

123256611

SHR:	100927672(KMT2B)

AFZ:

127556061

PCW:	110201341(KMT2B)

TVP:	118836691 118839019(KMT2B)

PBRV:

138154064(KMT2B)

MLAO:

141509358(KMT2B)

OAA:	103165316(KMT2B)

TACU:

119946179(KMT2B)

CNIC:

136000657(KMT2B)

ASN:	102382195(KMT2B)

CMY:	102931937(KMT2B)

CCAY:

125625630(KMT2B)

DCC:	119847681(KMT2B)

CPIC:

101950574(KMT2B)

TST:	117869515(KMT2B)

CABI:

116839067(KMT2B)

MRV:	120390254(KMT2B)

ACS:	100556600(kmt2b)

ASAO:

132780295(KMT2B)

PVT:	110089900(KMT2B)

SUND:

121915298(KMT2B)

PBI:	103058696(KMT2B)

PMUR:

107287999(KMT2B)

CTIG:

120300040(KMT2B)

TSR:	106550780(KMT2B)

PGUT:

117669309(KMT2B)

PCAE:

139321422(KMT2B)

APRI:

131204277(KMT2B)

PTEX:

113437418(KMT2B)

NSS:	113419887(KMT2B)

VKO:	123025799(KMT2B)

PMUA:

114603572(KMT2B)

PRAF:

128418584(KMT2B)

ZVI:	118085945(KMT2B)

HCG:	128332572(KMT2B)

GJA:	107108169(KMT2B)

STOW:

125434769(KMT2B)

EMC:	129343103(KMT2B)

XLA:	108696880 108697287

XTR:	100144721(kmt2b)

NPR:	108799776(KMT2B)

RTEM:

120916238(KMT2B)

ACAT:

141110317(KMT2B)

BBUF:

120993856(KMT2B)

BGAR:

122929120(KMT2B)

DTC:	141085190(KMT2B)

PWL:	138246500(KMT2B)

MUO:	115476211(KMT2B)

GSH:	117369214(KMT2B)

DRE:	560856(kmt2ba) 566825(kmt2bb)

SRX:	107724085 107739503 107745205 107747652

SANH:

107665484 107675870 107693264 107701550

SGH:	107571391(kmt2b) 107585719 107589473 107599517

CCAR:

109085861 109091702 109103645 109112389

CAUA:

113061939 113061940 113062164 113069211 113077794 113099189 113099201 113114935 113120015

CGIB:

127935245 127973165 127979018 128028980

PTET:

122323526(kmt2ba) 122358939(kmt2bb)

LROH:

127157412(kmt2bb) 127182023(kmt2ba)

GRF:	141285331(kmt2bb) 141289281(kmt2ba)

OMC:	131520426(kmt2bb) 131525286(kmt2ba)

PPRM:

120478822(kmt2bb) 120483374(kmt2ba)

RKG:	130070691(kmt2bb) 130070833(kmt2ba)

MAMB:

125248738 125275959(kmt2ba)

CIDE:

127495955 127501701

CERY:

137005442(kmt2bb) 137037316(kmt2ba)

MASI:

127421184 127422178 127425593 127429839

TROS:

130564368(kmt2bb) 130566892(kmt2ba)

TDW:	130415530(kmt2ba) 130428110(kmt2bb)

MANU:

129438380(kmt2bb) 129454902(kmt2ba)

PDAB:

135770815(kmt2bb) 135777017(kmt2ba)

IPU:	108272954(kmt2ba) 108277672(kmt2bb)

IFU:	128615464(kmt2ba) 128621843(kmt2bb)

PHYP:

113535181 113539221(kmt2b)

SMEO:

124381839(kmt2ba) 124394710(kmt2bb)

TFD:	113641273(kmt2ba) 113642372(kmt2bb)

TVC:	132842880(kmt2ba) 132858299(kmt2bb)

CGAR:

128515782(kmt2ba) 128532880(kmt2bb)

NGRA:

132870921(kmt2ba) 132901702(kmt2bb)

TRN:	134329867(kmt2ba) 134334871(kmt2bb)

AMEX:

103022217(kmt2bb)

CMAO:

118803799(kmt2bb) 118805983(kmt2ba)

EEE:	113572597 113586392(kmt2b)

CHAR:

105901266(kmt2bb) 105902047(kmt2ba)

SPIL:

134073066(kmt2ba) 134083480(kmt2bb)

ASAD:

121696297(kmt2ba) 121720875(kmt2bb)

TRU:	101064190 101073293(kmt2b) 115251849

TFS:	130518561(kmt2ba) 130532714(kmt2bb)

TNG:	GSTEN00032527G001

LCO:	104927558 104932361(kmt2b)

NCC:	104960690 104961389(kmt2b)

TBEN:

117477555(kmt2ba) 117480290(kmt2bb)

CGOB:

115016046 115021110(kmt2b)

PGEO:

117455559(kmt2ba) 117460876(kmt2bb)

GACU:

117542674(kmt2ba) 117553899(kmt2bb)

EMAC:

134861535(kmt2bb) 134874859

ELY:	117263326(kmt2ba) 117266030(kmt2bb)

EFO:	125893714(kmt2bb) 125904405(kmt2ba)

PLEP:

121946079(kmt2bb) 121957413(kmt2ba)

SLUC:

116047504(kmt2ba) 116049332(kmt2bb)

ECRA:

117946883(kmt2bb) 117956541(kmt2ba)

ESP:	116690992(kmt2b) 116701633

PFLV:

114556540(kmt2b) 114567833

GAT:	120811149(kmt2bb) 120826849(kmt2ba)

PPUG:

119197459(kmt2bb) 119218734(kmt2ba)

AFB:	129097316 129110093(kmt2bb)

CLUM:

117739150(kmt2ba) 117745348(kmt2bb)

PSWI:

130193257 130213312(kmt2bb)

CANA:

137780819(kmt2bb) 137784480(kmt2ba)

CVE:	137872740(kmt2ba) 137891730(kmt2bb)

MSAM:

119898296(kmt2bb) 119907919(kmt2ba)

SCHU:

122864889(kmt2ba) 122881423(kmt2bb)

CUD:	121512979(kmt2bb) 121524572(kmt2ba)

SPUL:

138584512(kmt2bb) 138608454(kmt2ba)

LMIX:

132984123(kmt2bb) 132991427(kmt2ba)

ALAT:

119005807(kmt2bb) 119016569(kmt2ba)

ASTR:

137602067(kmt2bb) 137607821(kmt2ba)

MZE:	101467874 101481309(kmt2b)

ONL:	100689867 100700132(kmt2b)

OAU:	116319815(kmt2bb) 116320047(kmt2ba)

OLA:	101157226 101174945(kmt2b)

OML:	112143279(kmt2bb) 112162480(kmt2ba)

CSAI:

133428222(kmt2bb) 133461414(kmt2ba)

XMA:	102222844 102229737(kmt2b)

XCO:	114142152(kmt2b) 114156616

XHE:	116713912(kmt2b) 116730674

PRET:

103472504 103478519(kmt2b)

PFOR:

103143107(kmt2b) 103146865

PLAI:

106945874(kmt2b) 106960535

PMEI:

106919951 106928418(kmt2b)

GAF:	122831339(kmt2bb) 122843072(kmt2ba)

PPRL:

129371385(kmt2bb) 129374949

CVG:	107086122(kmt2b) 107101115

CTUL:

119775533(kmt2bb) 119779627

GMU:	124864459(kmt2bb) 124879104

NFU:	107372442(kmt2b) 107394636

KMR:	108240680(kmt2ba) 108241999(kmt2bb)

ALIM:

106517704(kmt2b) 106537143

NWH:	119409464(kmt2bb) 119425834(kmt2ba)

AOCE:

111571387(kmt2ba) 111577070(kmt2bb)

EJA:	138194356(kmt2bb) 138215035(kmt2ba)

BFRE:

138618253(kmt2ba) 138619614(kmt2bb)

MCEP:

125015742(kmt2bb) 125020556

CSEM:

103388508(kmt2b) 103394161

POV:	109633105(kmt2b) 109638782

SSEN:

122774538(kmt2bb) 122786593(kmt2ba)

SSOE:

131447779(kmt2ba) 131470916(kmt2bb)

HHIP:

117770576 117776549(kmt2bb)

HSP:	118113601(kmt2bb) 118124314(kmt2ba)

PPLT:

128449864(kmt2bb) 128461549(kmt2ba)

SMAU:

118291930(kmt2ba) 118300255(kmt2bb)

LCF:	108888836 108890658(kmt2bb)

SDU:	111223127 111234049(kmt2b)

SLAL:

111657578 111664979(kmt2b)

XGL:	120783762(kmt2bb) 120786435(kmt2ba)

HCQ:	109514546 109525616(kmt2b)

SSCV:

125975503(kmt2bb) 125987183(kmt2ba)

SBIA:

133499114(kmt2ba) 133500576(kmt2bb)

PEE:	133396134 133401744(kmt2bb)

PTAO:

133471228(kmt2ba) 133479257(kmt2bb)

BPEC:

110161138 110171497(kmt2b)

ENY:	140361991(kmt2ba) 140374539(kmt2bb)

MALB:

109971699(kmt2b) 109973928

BSPL:

114843364(kmt2bb) 114866253(kmt2ba)

SJO:	128366747(kmt2bb) 128374749(kmt2ba)

SSCO:

133983773(kmt2bb) 133996134(kmt2ba)

TTY:	137191605(kmt2bb) 137198784(kmt2ba)

GMH:	115536064 115553251(kmt2b)

SASA:

106570121 106577926 106588247 106594944 106605615

STRU:

115164151 115173397 115176084 115177337

OTW:	112226731 112230014 112246968 112264909

OMY:	110487656 110496098 110510370 110538034

OGO:	123998007 124005299 124012097 124043698

ONE:	115101452 115128277 115131800 115140822

OKI:	109900891 109901820 109903796 109907621

OKE:	118367807 118373824 118398340 118399190

OMM:	135520478 135521995 135550132 135552342

OCLA:

139373372 139390242 139391633 139422874

SALP:

111955007 111955466 111958933 111964605

SNH:	120022385 120026748 120030911 120047222

SFON:

129819608 129831444 129838009 129857256

CCLU:

121556964 121571388 121585346 121586284

ELS:	105007527 105019114(kmt2b)

OEP:	134024181(kmt2bb)

SFM:	108930328(kmt2b)

PKI:	111833696(kmt2b) 111839650

AANG:

118212590(kmt2bb) 118233860

AROT:

135248757(kmt2bb) 135261526

CCOG:

133126236(kmt2bb) 133136527

LOC:	102692171(kmt2b)

PSPA:

121299031(kmt2bb) 121304193

ARUT:

117434041(kmt2bb) 117971976 117971978

HOC:

132808782

HAKA:

140732824(kmt2bb)

CGLO:

CSET:

AGB:

FCD:

DMK:

PJA:

PPOI:

EGL:

NVE:	5501691 5502141

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

AQU:

Reference

PMID:17707229

Authors

Demers C, Chaturvedi CP, Ranish JA, Juban G, Lai P, Morle F, Aebersold R, Dilworth FJ, Groudine M, Brand M

Title

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

Journal

Mol Cell 27:573-84 (2007)
DOI:10.1016/j.molcel.2007.06.022

Sequence

[hsa:9757]

Reference

PMID:17500065

Authors

Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K

Title

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

Journal

J Biol Chem 282:20395-406 (2007)
DOI:10.1074/jbc.M701574200

Sequence

[hsa:9757]

LinkDB

ORTHOLOGY: K09187

Entry

K09187                      KO

Symbol

MLL2, ALR

Name

[histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map04934

Cushing syndrome

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00570

Kabuki syndrome

H01613

Follicular lymphoma

H02434

Diffuse large B-cell lymphoma, not otherwise specified

H02943

Branchial arch abnormalities, choanal atresia, athelia, hearing loss, and hypothyroidism syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
   HMT complexes
    MLL-HCF complex
     K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2

Other DBs

GO:

0042800

Genes

HSA:	8085(KMT2D)

PTR:	100610362(KMT2D)

PPS:	100995808(KMT2D)

GGO:	101144774(KMT2D)

PON:	100441715(KMT2D)

PPYG:

129009394(KMT2D)

NLE:	100586637(KMT2D)

HMH:	116461666(KMT2D)

SSYN:

129491126(KMT2D)

MCC:	710795(KMT2D)

MCF:	102123773(KMT2D)

MTHB:

126930146

MNI:	105492887(KMT2D)

CSAB:

103238253(KMT2D)

CATY:

105580395(KMT2D)

PANU:

101013975(KMT2D)

TGE:	112634043(KMT2D)

MLEU:

105544907(KMT2D)

RRO:	104679726(KMT2D)

RBB:	108543918(KMT2D)

TFN:	117090180(KMT2D)

PTEH:

111542040(KMT2D)

CANG:

105507638(KMT2D)

CJC:	100408425(KMT2D)

SBQ:	101037539(KMT2D)

CIMI:

108316029(KMT2D)

ANAN:

105709457(KMT2D)

CSYR:

103273452(KMT2D)

MMUR:

105869278(KMT2D)

LCAT:

123640430(KMT2D)

PCOQ:

105817625(KMT2D)

OGA:	100944849(KMT2D)

MMU:	381022(Kmt2d)

MCAL:

110310214(Kmt2d)

MPAH:

110334561(Kmt2d)

RNO:	100362634(Kmt2d)

MCOC:

116079206(Kmt2d)

ANU:	117719408(Kmt2d)

ASYL:

127667264(Kmt2d)

MUN:	110547438(Kmt2d)

CGE:	100765465(Kmt2d)

MAUA:

101839981(Kmt2d)

PROB:

127226039(Kmt2d)

PLEU:

114708576(Kmt2d)

MORG:

121441441(Kmt2d)

MFOT:

126493757

AAMP:

119824034(Kmt2d)

NGI:	103750570(Kmt2d)

HGL:	101718411(Kmt2d)

CPOC:

100728357(Kmt2d)

CCAN:

109694824(Kmt2d)

DORD:

105987518(Kmt2d)

DSP:	122106312(Kmt2d)

DMER:

138840248(Kmt2d)

PLOP:

125365227(Kmt2d)

NCAR:

124984039

MMMA:

107148596(Kmt2d)

ITI:	101971216(Kmt2d)

OCU:

100357052

OPI:	101525881(KMT2D)

TUP:	102480722(KMT2D)

GVR:	103588851(KMT2D)

CFA:	486558(KMT2D)

CLUD:

112678280(KMT2D)

VVP:	112921101(KMT2D)

VLG:	121480058(KMT2D)

NPO:	129517321(KMT2D)

AML:	100479447(KMT2D)

UMR:	103675622(KMT2D)

UAH:	113257661(KMT2D)

UAR:	123794786(KMT2D)

ELK:

111157787

LLV:

125107080

MPUF:

101672336(KMT2D)

MNP:	132019637(KMT2D)

MLK:	131838809(KMT2D)

NVS:	122891630(KMT2D)

ORO:	101369213(KMT2D)

EJU:	114225810(KMT2D)

ZCA:	113921953(KMT2D)

MLX:	118008878(KMT2D)

NSU:	110593565(KMT2D)

LWW:	102742632(KMT2D)

FCA:	101095268(KMT2D)

PYU:	121038633(KMT2D)

PCOO:

112867498(KMT2D)

PBG:	122472347(KMT2D)

PVIV:

125169640(KMT2D)

LRUF:

124501541

LGF:	123591041(KMT2D)

AJU:

106969329

PTG:	102962859(KMT2D)

PPAD:

109249058(KMT2D)

PUC:

125919016

PLEZ:

122224500(KMT2D)

HHV:	120223002(KMT2D)

BTA:	506805(KMT2D)

BOM:	102268887(KMT2D)

BIU:	109559148(KMT2D)

BBUB:

102401706(KMT2D)

BBIS:

105001687(KMT2D)

CHX:	102168698(KMT2D)

OAS:	101120741(KMT2D)

BTAX:

128048807(KMT2D)

CSUM:

138077771(KMT2D)

ODA:	120858214 120861279

CCAD:

122427655(KMT2D)

MREE:

136167167(KMT2D)

OVR:	110133172(KMT2D)

MBEZ:

129536737(KMT2D)

SSC:	110260656(KMT2D)

CFR:	102515223(KMT2D)

CBAI:

105076349(KMT2D)

CDK:	105103813(KMT2D)

VPC:	102536075(KMT2D)

BACU:

103004413(KMT2D)

BMUS:

118902460(KMT2D)

LVE:	103082116(KMT2D)

OOR:	101269640(KMT2D)

LALB:

132529611(KMT2D)

GMF:	115841367(KMT2D)

DDP:	132433647(KMT2D)

DLE:	111174034(KMT2D)

PCAD:

102981848(KMT2D)

PSIU:

116760790(KMT2D)

PPHC:

136130352(KMT2D)

NASI:

112394312(KMT2D)

ECB:	100058932(KMT2D)

EPZ:	103552202(KMT2D)

EAI:	106836860(KMT2D)

MYB:	102244965(KMT2D)

MYD:	102762410(KMT2D)

MMYO:

118650974(KMT2D)

MLF:	102434400(KMT2D)

MDT:	132227534(KMT2D)

MYUM:

139007171(KMT2D)

PKL:	118730318(KMT2D)

EFUS:

129149802(KMT2D)

MNA:	107528109(KMT2D)

DRO:	112318232(KMT2D)

SHON:

118976513(KMT2D)

AJM:	119042258(KMT2D)

PDIC:

114512768(KMT2D)

PHAS:

123813126(KMT2D)

MMF:	118624157(KMT2D)

PPAM:

129084875(KMT2D)

HAI:	109393224(KMT2D)

RFQ:	117028056(KMT2D)

PALE:

102888593(KMT2D)

PGIG:

120618206(KMT2D)

PVP:	105297532(KMT2D)

RAY:	107514237(KMT2D)

MJV:	108383409(KMT2D)

TOD:	119247884(KMT2D)

SARA:

101556381(KMT2D)

SFUM:

130029207(KMT2D)

SETR:

126022449(KMT2D)

LAV:	100670013(KMT2D)

TMU:

101353099

ETF:	101652640(KMT2D)

DNM:	101443835(KMT2D)

MDO:	103099827(KMT2D)

GAS:	123250244(KMT2D)

SHR:	100928575(KMT2D)

AFZ:

127538052

PCW:	110194047(KMT2D)

TVP:	118850016(KMT2D)

PBRV:

138164682(KMT2D)

MLAO:

141514870(KMT2D)

TACU:

119932914(KMT2D)

GGA:	425846(KMT2D)

PCOC:

116239278(KMT2D)

MGP:

104915798

CJO:	107325738(KMT2D)

TPAI:

128074181(KMT2D)

LMUT:

125685519(KMT2D)

NMEL:

110389135(KMT2D)

APLA:

119715282(KMT2D)

ACYG:

106047718(KMT2D)

CATA:

118261349(KMT2D)

AFUL:

116499959(KMT2D)

TGU:	100226907(KMT2D)

LSR:	110480395(KMT2D)

SCAN:

103824625(KMT2D)

PMOA:

120499503(KMT2D)

OTC:	121334290(KMT2D)

PRUF:

121356323(KMT2D)

ATRC:

139604787(KMT2D)

FAB:	101818086(KMT2D)

OMA:	130265671(KMT2D)

PHI:	102100454(KMT2D)

PMAJ:

107198594(KMT2D)

CBRC:

103611912(KMT2D)

ACOE:

138100104(KMT2D)

ZLE:	135459047(KMT2D)

SVG:	106862663(KMT2D)

MMEA:

130584132(KMT2D)

HRT:	120764441(KMT2D)

SATI:

136372807(KMT2D)

CCIC:

134054841(KMT2D)

SHAB:

115618585(KMT2D)

TALA:

116963045(KMT2D)

ACHC:

115350939(KMT2D)

HLE:	104831179(KMT2D)

AGEN:

126046316

HHAR:

128151727(KMT2D)

PPUS:

135174308(KMT2D)

CBOY:

140644343(KMT2D)

CNIC:

136000577(KMT2D)

CUCA:

104055021(KMT2D)

CVF:	104284814(KMT2D)

RTD:	128901209(KMT2D)

CRID:

134526768(KMT2D)

LMIC:

141733871(KMT2D)

AROW:

112960842(KMT2D)

NPD:	112954231(KMT2D)

DNE:	112996078(KMT2D)

ASN:	102373099(KMT2D)

CPOO:

109323545(KMT2D)

GGN:	109305426(KMT2D)

CMY:	102944171(KMT2D)

CCAY:

125627479(KMT2D)

DCC:	119845758(KMT2D)

CPIC:

101934288(KMT2D)

TST:	117888986(KMT2D)

CABI:

116827822(KMT2D)

MRV:	120390931(KMT2D)

ACS:	100554175(kmt2d)

ASAO:

132768219(KMT2D)

PVT:	110075080(KMT2D)

SUND:

121922468(KMT2D)

PMUR:

107286389(KMT2D)

CTIG:

120306148(KMT2D)

PCAE:

139312729(KMT2D)

APRI:

131189511(KMT2D)

VKO:	123033085(KMT2D)

PMUA:

114587663

PRAF:

128407190

ZVI:	118079598(KMT2D)

HCG:	128342849(KMT2D)

GJA:	107105838(KMT2D)

STOW:

125428034(KMT2D)

EMC:	129346200(KMT2D)

XLA:	108708548(kmt2d.L) 108708990(kmt2d.S)

XTR:	100494109(kmt2d)

NPR:	108791395(KMT2D)

RTEM:

120929576(KMT2D)

ACAT:

141127520(KMT2D)

BBUF:

120995961(KMT2D)

BGAR:

122930564(KMT2D)

DTC:	141076110(KMT2D)

PWL:	138292102(KMT2D)

MUO:	115465933(KMT2D)

GSH:

117357250

DRE:	100536523(kmt2d)

SRX:	107708781(kmt2d) 107716211

SANH:

107681934 107695802

SGH:	107563643 107570495(kmt2d)

CCAR:

109083090 109088326

CAUA:

113065480 113070551

CGIB:

127945167 128011063

PTET:

122328571 122329050(kmt2d)

LROH:

127154390(kmt2d)

GRF:	141290801(kmt2d)

OMC:	131531604(kmt2d)

PPRM:

120463585(kmt2d)

RKG:	130073522(kmt2d)

MAMB:

125259813(kmt2d)

CERY:

137009658(kmt2d)

MASI:

127418716 127419740

TROS:

130545175(kmt2d)

TDW:	130409817(kmt2d)

MANU:

129430804(kmt2d)

PDAB:

135775435(kmt2d)

IPU:	108275851(kmt2d)

IFU:	128619792(kmt2d)

PHYP:

113530648(kmt2d)

TFD:	113658175(kmt2d)

TVC:	132861885(kmt2d)

CGAR:

128510595(kmt2d)

NGRA:

132897109(kmt2d)

TRN:	134333770(kmt2d)

AMEX:

103042576(kmt2d)

CMAO:

118822997(kmt2d)

EEE:	113584431(kmt2d)

CHAR:

105897331(kmt2d)

SPIL:

134087134(kmt2d)

ASAD:

121713458(kmt2d)

TRU:	101062458(kmt2d)

TFS:	130529879(kmt2d)

TNG:	GSTEN00028083G001

LCO:	104932523(kmt2d)

NCC:	104956939(kmt2d)

TBEN:

117494251(kmt2d)

CGOB:

115010606(kmt2d)

PGEO:

117449483(kmt2d)

GACU:

117542045(kmt2d)

EMAC:

134870678(kmt2d)

ELY:	117258597(kmt2d)

EFO:	125891096(kmt2d)

PLEP:

121946657(kmt2d)

SLUC:

116038913(kmt2d)

ECRA:

117947742(kmt2d)

ESP:	116692906(kmt2d)

PFLV:

114559193(kmt2d)

GAT:	120829072(kmt2d)

PPUG:

119206538(kmt2d)

AFB:	129100258(kmt2d)

CLUM:

117733633(kmt2d)

PSWI:

130199076(kmt2d)

CANA:

137800868(kmt2d)

CVE:	137889633(kmt2d)

MSAM:

119887711 119919297(kmt2d)

SCHU:

122883461(kmt2d)

CUD:	121517403(kmt2d)

SPUL:

138590411(kmt2d)

LMIX:

132990413(kmt2d)

ALAT:

119023106(kmt2d)

ASTR:

137603388(kmt2d)

MZE:	101486529(kmt2d)

ONL:	100706752(kmt2d)

OAU:	116325808(kmt2d)

OLA:	101172242(kmt2d)

OML:	112159276(kmt2d)

CSAI:

133457186(kmt2d)

XMA:	102237866(kmt2d)

XCO:	114140852(kmt2d)

XHE:	116727224(kmt2d)

PRET:

103467355(kmt2d)

PFOR:

103141131(kmt2d)

PLAI:

106959285(kmt2d)

PMEI:

106921544(kmt2d)

GAF:	122828614(kmt2d)

PPRL:

129372510(kmt2d)

CVG:	107086766(kmt2d)

CTUL:

119781989(kmt2d)

GMU:	124866846(kmt2d)

NFU:	107390885(kmt2d)

KMR:	108235223(kmt2d)

ALIM:

106524867(kmt2d)

NWH:	119417622(kmt2d)

AOCE:

111577439(kmt2d)

EJA:	138192713(kmt2d)

BFRE:

138614838(kmt2d)

MCEP:

125019949(kmt2d)

CSEM:

103385102(kmt2d)

POV:	109630747(kmt2d)

SSEN:

122777068(kmt2d)

SSOE:

131468806(kmt2d)

HHIP:

117764077(kmt2d)

HSP:	118110520(kmt2d)

PPLT:

128442001(kmt2d)

SMAU:

118316365(kmt2d)

LCF:

108876442

SDU:	111219023(kmt2d)

SLAL:

111668971(kmt2d)

XGL:	120804417(kmt2d)

HCQ:	109531346(kmt2d)

SSCV:

125989448(kmt2d)

SBIA:

133505432(kmt2d)

PEE:	133402236(kmt2d)

PTAO:

133478443(kmt2d)

BPEC:

110164958(kmt2d)

ENY:	140363418(kmt2d)

MALB:

109968659(kmt2d)

BSPL:

114858181(kmt2d)

SJO:	128356814(kmt2d)

SSCO:

133987164(kmt2d)

TTY:	137184480(kmt2d)

GMH:	115547788(kmt2d)

SASA:

106567046(kmt2d) 106572669

STRU:

115165500 115167836(kmt2d)

OTW:	112221704(kmt2d) 112247360

OMY:	110491964(kmt2d) 110532701

OGO:	124032266 124046095(kmt2d)

ONE:	115102572(kmt2d) 115132488

OKI:	109869140(kmt2d) 109878425

OKE:	118360113(kmt2d) 118360673

OMM:	135504020 135528468(kmt2d)

OCLA:

139368414 139416829

SALP:

111966806 111976311

SNH:	120059601 120061017

SFON:

129829672 129860551(kmt2d)

CCLU:

121537893 121546498

ELS:	105013562(kmt2d)

OEP:	134018532(kmt2d)

SFM:

108939256

PKI:

111860624

AANG:

118207247(kmt2d) 118211876

AROT:

135234420(kmt2d) 135238111

CCOG:

133110709 133138156(kmt2d)

LOC:	102683854(kmt2d)

PSPA:

121308967(kmt2d)

ARUT:

117401082 117967100

LCM:	102354014(KMT2D)

CPLA:

122543312(kmt2d)

HOC:	132805781(kmt2d)

LERI:

129714725(kmt2d)

HAKA:

140741152(kmt2d)

TAD:	TRIADDRAFT_62004

» show all

Reference

PMID:20808952

Authors

Andreu-Vieyra CV, Chen R, Agno JE, Glaser S, Anastassiadis K, Stewart AF, Matzuk MM

Title

MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.

Journal

PLoS Biol 8:e1000453 (2010)
DOI:10.1371/journal.pbio.1000453

Sequence

[hsa:8085] [mmu:381022]

Reference

PMID:20236313

Authors

Ansari KI, Mandal SS

Title

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

Journal

FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x

Reference

PMID:9247308

Authors

Prasad R, Zhadanov AB, Sedkov Y, Bullrich F, Druck T, Rallapalli R, Yano T, Alder H, Croce CM, Huebner K, Mazo A, Canaani E

Title

Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.

Journal

Oncogene 15:549-60 (1997)
DOI:10.1038/sj.onc.1201211

Sequence

[hsa:8085]

LinkDB

DBGET integrated database retrieval system