KEGG   ORTHOLOGY: K17448
Entry
K17448                      KO                                     
Symbol
SHC3
Name
SHC-transforming protein 3
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04510  Focal adhesion
map04650  Natural killer cell mediated cytotoxicity
map04722  Neurotrophin signaling pathway
map04910  Insulin signaling pathway
map04915  Estrogen signaling pathway
map04917  Prolactin signaling pathway
map04926  Relaxin signaling pathway
map04935  Growth hormone synthesis, secretion and action
map05034  Alcoholism
map05100  Bacterial invasion of epithelial cells
map05214  Glioma
map05220  Chronic myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04014 Ras signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04072 Phospholipase D signaling pathway
    K17448  SHC3; SHC-transforming protein 3
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17448  SHC3; SHC-transforming protein 3
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17448  SHC3; SHC-transforming protein 3
   04062 Chemokine signaling pathway
    K17448  SHC3; SHC-transforming protein 3
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04915 Estrogen signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04917 Prolactin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04926 Relaxin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04935 Growth hormone synthesis, secretion and action
    K17448  SHC3; SHC-transforming protein 3
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
 09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17448  SHC3; SHC-transforming protein 3
   05226 Gastric cancer
    K17448  SHC3; SHC-transforming protein 3
   05214 Glioma
    K17448  SHC3; SHC-transforming protein 3
   05220 Chronic myeloid leukemia
    K17448  SHC3; SHC-transforming protein 3
   05224 Breast cancer
    K17448  SHC3; SHC-transforming protein 3
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17448  SHC3; SHC-transforming protein 3
  09165 Substance dependence
   05034 Alcoholism
    K17448  SHC3; SHC-transforming protein 3
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17448  SHC3; SHC-transforming protein 3
   01522 Endocrine resistance
    K17448  SHC3; SHC-transforming protein 3
Genes
HSA: 53358(SHC3)
PTR: 450176(SHC3)
PPS: 100972624(SHC3)
GGO: 101127418(SHC3)
PON: 100462011(SHC3)
PPYG: 129044343(SHC3)
NLE: 100589484(SHC3)
HMH: 116475219(SHC3)
SSYN: 129479239(SHC3)
MCC: 574275(SHC3)
MCF: 102130150(SHC3)
MTHB: 126937656
MNI: 105498803(SHC3)
CSAB: 103219725(SHC3)
CATY: 105584282(SHC3)
PANU: 101024393(SHC3)
TGE: 112608168(SHC3)
MLEU: 105535962(SHC3)
RRO: 104668515(SHC3)
RBB: 108532239(SHC3)
TFN: 117098366(SHC3)
PTEH: 111527961(SHC3)
CANG: 105516026(SHC3)
CJC: 100402406(SHC3)
SBQ: 101028764(SHC3)
CIMI: 108304324(SHC3)
ANAN: 105724608(SHC3)
CSYR: 103257751(SHC3)
MMUR: 105876163(SHC3)
LCAT: 123645857(SHC3)
PCOQ: 105817773(SHC3)
OGA: 100952749(SHC3)
MMU: 20418(Shc3)
MCAL: 110308134(Shc3)
MPAH: 110333751(Shc3)
RNO: 114858(Shc3)
MCOC: 116081462(Shc3)
ANU: 117713721(Shc3)
ASYL: 127664792(Shc3)
MUN: 110559069(Shc3)
CGE: 100760879(Shc3)
MAUA: 101832424(Shc3)
PROB: 127229241(Shc3)
PLEU: 114689488(Shc3)
MORG: 121445378 121453450
MFOT: 126502881
AAMP: 119817129(Shc3)
NGI: 103726215(Shc3)
HGL: 101715363(Shc3)
CPOC: 100732336(Shc3)
CCAN: 109675955(Shc3)
DORD: 105990929(Shc3)
DSP: 122113790(Shc3)
PLOP: 125355540(Shc3)
NCAR: 124965516
MMMA: 107157649(Shc3)
OCU: 100353992
OPI: 101522287(SHC3)
TUP: 102472295(SHC3)
GVR: 103608083(SHC3)
CFA: 476352(SHC3)
CLUD: 112644865(SHC3)
VVP: 112908627(SHC3)
VLG: 121485154(SHC3)
NPO: 129500459(SHC3)
AML: 100468080(SHC3)
UMR: 103663185(SHC3)
UAH: 113270120(SHC3)
UAR: 123776524(SHC3)
ELK: 111153623
LLV: 125083737
MPUF: 101676109(SHC3)
MNP: 132024896(SHC3)
MLK: 131812476(SHC3)
NVS: 122917799(SHC3)
ORO: 101375500(SHC3)
EJU: 114219804(SHC3)
ZCA: 113935041(SHC3)
MLX: 118026255(SHC3)
NSU: 110584374(SHC3)
LWW: 102739229(SHC3)
FCA: 101095865(SHC3)
PYU: 121013551(SHC3)
PCOO: 112868533(SHC3)
PBG: 122475305(SHC3)
PVIV: 125150616(SHC3)
LRUF: 124524856
LGF: 123592464(SHC3)
AJU: 106987970
PTG: 102965813(SHC3)
PPAD: 109275536(SHC3)
PUC: 125929330
PLEZ: 122204960(SHC3)
HHV: 120237954(SHC3)
BTA: 512696(SHC3)
BOM: 102268950(SHC3)
BIU: 109562580(SHC3)
BBUB: 102411865(SHC3)
BBIS: 104992086(SHC3)
CHX: 102189677(SHC3)
OAS: 101107936(SHC3)
BTAX: 128052614(SHC3)
CSUM: 138081300(SHC3)
ODA: 120861915(SHC3)
CCAD: 122431762(SHC3)
MREE: 136176762(SHC3)
OVR: 110147051(SHC3)
MBEZ: 129557186(SHC3)
SSC: 102164918(SHC3)
CFR: 102508169(SHC3)
CBAI: 105065419(SHC3)
CDK: 105086410(SHC3)
VPC: 102541852(SHC3)
BACU: 103017986(SHC3)
BMUS: 118896483(SHC3)
LVE: 103078122(SHC3)
OOR: 101280480(SHC3)
LALB: 132522995(SHC3)
DLE: 111167641(SHC3)
PCAD: 102977456(SHC3)
PSIU: 116755660(SHC3)
NASI: 112390850(SHC3)
ECB: 100061926(SHC3)
EPZ: 103552516(SHC3)
EAI: 106841633(SHC3)
MYB: 102245983(SHC3)
MYD: 102772432(SHC3)
MMYO: 118652528(SHC3)
MLF: 102435382(SHC3)
MDT: 132211802(SHC3)
MYUM: 138998810(SHC3)
PKL: 118708684(SHC3)
EFUS: 103297925(SHC3)
MNA: 107529164(SHC3)
DRO: 112307260(SHC3)
SHON: 118993733(SHC3)
AJM: 119040940(SHC3)
PDIC: 114512532(SHC3)
PHAS: 123815569(SHC3)
MMF: 118629877(SHC3)
PPAM: 129082357(SHC3)
HAI: 109376923(SHC3)
RFQ: 117031898(SHC3)
PALE: 102879956(SHC3)
PGIG: 120594118(SHC3)
PVP: 105300265(SHC3)
RAY: 107504308(SHC3)
MJV: 108394387(SHC3)
TOD: 119231849(SHC3)
SARA: 101550468(SHC3)
SFUM: 130035187(SHC3)
SETR: 126003375(SHC3)
LAV: 100659669(SHC3)
TMU: 101360084
ETF: 101644193(SHC3)
DNM: 101417480(SHC3)
MDO: 100024603(SHC3)
GAS: 123231336(SHC3)
SHR: 100914800(SHC3)
AFZ: 127562429
PCW: 110223827(SHC3)
TVP: 118834894(SHC3)
PBRV: 138160950(SHC3)
GGA: 431265(SHC3)
PCOC: 116236693(SHC3)
CJO: 107306293(SHC3)
TPAI: 128089591(SHC3)
LMUT: 125687232(SHC3)
NMEL: 110390178(SHC3)
APLA: 101792705(SHC3)
ACYG: 106045108(SHC3)
CATA: 118259571(SHC3)
AFUL: 116500840(SHC3)
TGU: 100221851(SHC3)
LSR: 110470634(SHC3)
SCAN: 103821251(SHC3)
PMOA: 120509461(SHC3)
OTC: 121332732(SHC3)
PRUF: 121363937(SHC3)
ATRC: 139588934(SHC3)
GFR: 102039603(SHC3)
FAB: 101820104(SHC3)
OMA: 130265527(SHC3)
PHI: 102110162(SHC3)
PMAJ: 107216331(SHC3)
CCAE: 111941731(SHC3)
CCW: 104689719(SHC3)
CBRC: 103621374(SHC3)
ACOE: 138103161(SHC3)
ETL: 114061143(SHC3)
ZAB: 102068447(SHC3)
ZLE: 135459293(SHC3)
ACHL: 103808012(SHC3)
SVG: 106848871(SHC3)
MMEA: 130584683(SHC3)
HRT: 120765905(SHC3)
SATI: 136374400(SHC3)
CCIC: 134056281(SHC3)
FPG: 101913271(SHC3)
FCH: 102053453(SHC3)
CCRI: 104158850(SHC3)
NNT: 104401767(SHC3)
SHAB: 115600820(SHC3)
ACUN: 113490173(SHC3)
TALA: 104357645(SHC3)
ACHC: 115337159(SHC3)
HALD: 104319776(SHC3)
HLE: 104832480(SHC3)
AGEN: 126036635
HHAR: 128137360(SHC3)
GCL: 127027510
CSTI: 104561284(SHC3)
LDI: 104343238(SHC3)
MNB: 103777600(SHC3)
DPUB: 104296823(SHC3)
PPUS: 135193242(SHC3)
AVIT: 104274577(SHC3)
BRHI: 104495386(SHC3)
EGZ: 104126913(SHC3)
NNI: 104009737(SHC3)
PCRI: 104029588(SHC3)
PCAO: 104045338(SHC3)
PADL: 103921606(SHC3)
AFOR: 103900860(SHC3)
FGA: 104083819(SHC3)
GSTE: 104256868(SHC3)
CLV: 102091397(SHC3)
MUI: 104537582(SHC3)
PGUU: 104465733(SHC3)
PLET: 104619623(SHC3)
EHS: 104511251(SHC3)
CMAC: 104474491(SHC3)
CUCA: 104064071(SHC3)
TEO: 104382052(SHC3)
BREG: 104634670(SHC3)
OHA: 104331392(SHC3)
ACAR: 104528759(SHC3)
CPEA: 104387006(SHC3)
CVF: 104287014(SHC3)
RTD: 128902647(SHC3)
CRID: 134508927(SHC3)
AAM: 106495478(SHC3)
AROW: 112965253(SHC3)
NPD: 112959236(SHC3)
TGT: 104580452(SHC3)
DNE: 112978778(SHC3)
SCAM: 104150288(SHC3)
ASN: 102374227(SHC3)
AMJ: 102574737(SHC3)
CPOO: 109323712(SHC3)
GGN: 109297521(SHC3)
PSS: 102449148(SHC3)
CMY: 102938973(SHC3)
CCAY: 125636728(SHC3)
DCC: 119856341(SHC3)
CPIC: 101943152(SHC3)
TST: 117879421(SHC3)
CABI: 116820123(SHC3)
MRV: 120407261(SHC3)
ACS: 100560033(shc3)
ASAO: 132767282(SHC3)
PVT: 110080566(SHC3)
SUND: 121923451(SHC3)
PBI: 103061531(SHC3)
PMUR: 107293823(SHC3)
CTIG: 120316152(SHC3)
TSR: 106543844(SHC3)
PGUT: 117661352(SHC3)
APRI: 131193358(SHC3)
PTEX: 113438512(SHC3)
NSS: 113414290(SHC3)
VKO: 123031493(SHC3)
PMUA: 114606494(SHC3)
PRAF: 128423236(SHC3)
ZVI: 118076970(SHC3)
HCG: 128346323(SHC3)
GJA: 107108634(SHC3)
STOW: 125436789(SHC3)
EMC: 129335216(SHC3)
XLA: 108706999 108714850
XTR: 100101768(shc3)
NPR: 108792509(SHC3)
RTEM: 120941594(SHC3)
BBUF: 120991487(SHC3)
BGAR: 122932862(SHC3)
PWL: 138287202(SHC3)
MUO: 115463262(SHC3)
GSH: 117352322(SHC3)
DRE: 100332111(shc3)
SRX: 107713521(shc3) 107731079
SANH: 107653345 107675707
SGH: 107585661 107599382
CCAR: 109077279 109108077
CAUA: 113038997 113039148 113064459
CGIB: 127942206 127985828
PTET: 122332578(shc3)
LROH: 127152212(shc3)
OMC: 131528767(shc3)
PPRM: 120471251(shc3)
RKG: 130073035(shc3)
MAMB: 125252380(shc3)
CIDE: 127503996
CERY: 137012826(shc3)
MASI: 127429246 127430834
TROS: 130570122(shc3)
TDW: 130407777(shc3)
MANU: 129423808(shc3)
PDAB: 135721511(shc3)
IPU: 108279345(shc3)
IFU: 128622479(shc3)
PHYP: 113535807
SMEO: 124398433(shc3)
TFD: 113646387(shc3)
TVC: 132859926(shc3)
CGAR: 128507586(shc3)
NGRA: 132894852(shc3)
TRN: 134330679(shc3)
AMEX: 103034159(shc3)
CMAO: 118820670(shc3)
EEE: 113573720
CHAR: 105911487(shc3)
SPIL: 134100903(shc3)
TRU: 101074404
TFS: 130517765(shc3)
TNG: GSTEN00034719G001
LCO: 104928532(shc3)
NCC: 104940972(shc3)
TBEN: 117476810(shc3)
CGOB: 115016959(shc3)
PGEO: 117456357(shc3)
GACU: 117538998(shc3)
EMAC: 134867979(shc3)
ELY: 117269992(shc3)
EFO: 125905484(shc3)
PLEP: 121960165(shc3)
SLUC: 116062835(shc3)
ECRA: 117959810(shc3)
ESP: 116704435(shc3)
PFLV: 114571470(shc3)
GAT: 120831599(shc3)
PPUG: 119226750(shc3)
AFB: 129102605(shc3)
CLUM: 117740595(shc3)
PSWI: 130205466(shc3)
CANA: 137783684(shc3)
CVE: 137868156(shc3)
MSAM: 119914153(shc3) 119915020
SCHU: 122865784(shc3)
CUD: 121525455(shc3)
SPUL: 138602188(shc3)
LMIX: 132991778(shc3)
ALAT: 119030496(shc3)
ASTR: 137608631(shc3)
MZE: 101471658
ONL: 100703092
OAU: 116331844(shc3)
OLA: 101174847(shc3)
OML: 112163126(shc3)
CSAI: 133454532(shc3)
XMA: 102217649
XCO: 114149224(shc3)
XHE: 116724009(shc3)
PRET: 103473860
PFOR: 103142750
PLAI: 106943163 106965218
PMEI: 106903214 106912419
GAF: 122819636(shc3)
PPRL: 129366485(shc3)
CVG: 107085834(shc3)
CTUL: 119789839(shc3)
GMU: 124872742(shc3)
NFU: 107374683(shc3)
KMR: 108231103(shc3)
ALIM: 106534007(shc3)
NWH: 119424705(shc3)
AOCE: 111585351(shc3)
EJA: 138211282(shc3)
BFRE: 138628003(shc3)
MCEP: 124997099(shc3)
CSEM: 103390284(shc3)
POV: 109642612
SSEN: 122760760(shc3)
SSOE: 131446339(shc3)
HHIP: 117771278(shc3)
HSP: 118098019(shc3)
PPLT: 128425391(shc3)
SMAU: 118284822(shc3)
LCF: 108874038
SDU: 111234683(shc3)
SLAL: 111664807(shc3)
XGL: 120806701(shc3)
HCQ: 109523621(shc3)
SSCV: 125979601(shc3)
SBIA: 133490578(shc3)
PEE: 133414206(shc3)
PTAO: 133490346(shc3)
BPEC: 110160455
ENY: 140366946(shc3)
MALB: 109960608
BSPL: 114866659(shc3)
SJO: 128380306(shc3)
SSCO: 133995341(shc3)
GMH: 115532490(shc3)
SASA: 106568489(shc3)
STRU: 115149458(shc3)
OTW: 112257355(shc3)
OMY: 110536941(shc3)
OGO: 124000022(shc3)
ONE: 115106013
OKI: 109893621(shc3)
OKE: 118372967(shc3)
OMM: 135548104(shc3)
OCLA: 139421860
SALP: 111980239
SNH: 120044764(shc3)
CCLU: 121573424 121582728
ELS: 105031363(shc3)
OEP: 134038850(shc3)
SFM: 108932838(shc3)
PKI: 111833617(shc3)
AANG: 118213341(shc3)
AROT: 135239495(shc3)
CCOG: 133105546(shc3)
LOC: 102685302(shc3)
PSPA: 121302023 121315808
ARUT: 117409208 117962916
PSEX: 120532944(shc3)
LCM: 102362793(SHC3)
CMK: 103182842
RTP: 109919981(shc3)
CPLA: 122561732
HOC: 132825937(shc3)
LERI: 129695696(shc3)
AGIF: 122857946
 » show all
Reference
PMID:8808684
  Authors
Nakamura T, Sanokawa R, Sasaki Y, Ayusawa D, Oishi M, Mori N
  Title
N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway.
  Journal
Oncogene 13:1111-21 (1996)
  Sequence
[hsa:53358]
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