KEGG ORTHOLOGY: K17454

ORTHOLOGY: K17454

Entry

K17454                      KO

Symbol

E2F1

Name

transcription factor E2F1

Pathway

map01522

Endocrine resistance

map04110

Cell cycle

map04137

Mitophagy - animal

map04218

Cellular senescence

map04934

Cushing syndrome

map05160

Hepatitis C

map05161

Hepatitis B

map05163

Human cytomegalovirus infection

map05165

Human papillomavirus infection

map05166

Human T-cell leukemia virus 1 infection

map05167

Kaposi sarcoma-associated herpesvirus infection

map05169

Epstein-Barr virus infection

map05200

Pathways in cancer

map05206

MicroRNAs in cancer

map05207

Chemical carcinogenesis - receptor activation

map05212

Pancreatic cancer

map05214

Glioma

map05215

Prostate cancer

map05218

Melanoma

map05219

Bladder cancer

map05220

Chronic myeloid leukemia

map05222

Small cell lung cancer

map05223

Non-small cell lung cancer

map05224

Breast cancer

map05225

Hepatocellular carcinoma

map05226

Gastric cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K17454  E2F1; transcription factor E2F1
  09143 Cell growth and death
   04110 Cell cycle
    K17454  E2F1; transcription factor E2F1
   04218 Cellular senescence
    K17454  E2F1; transcription factor E2F1
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K17454  E2F1; transcription factor E2F1
   05206 MicroRNAs in cancer
    K17454  E2F1; transcription factor E2F1
   05207 Chemical carcinogenesis - receptor activation
    K17454  E2F1; transcription factor E2F1
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K17454  E2F1; transcription factor E2F1
   05225 Hepatocellular carcinoma
    K17454  E2F1; transcription factor E2F1
   05226 Gastric cancer
    K17454  E2F1; transcription factor E2F1
   05214 Glioma
    K17454  E2F1; transcription factor E2F1
   05220 Chronic myeloid leukemia
    K17454  E2F1; transcription factor E2F1
   05218 Melanoma
    K17454  E2F1; transcription factor E2F1
   05219 Bladder cancer
    K17454  E2F1; transcription factor E2F1
   05215 Prostate cancer
    K17454  E2F1; transcription factor E2F1
   05224 Breast cancer
    K17454  E2F1; transcription factor E2F1
   05222 Small cell lung cancer
    K17454  E2F1; transcription factor E2F1
   05223 Non-small cell lung cancer
    K17454  E2F1; transcription factor E2F1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K17454  E2F1; transcription factor E2F1
   05161 Hepatitis B
    K17454  E2F1; transcription factor E2F1
   05160 Hepatitis C
    K17454  E2F1; transcription factor E2F1
   05163 Human cytomegalovirus infection
    K17454  E2F1; transcription factor E2F1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K17454  E2F1; transcription factor E2F1
   05169 Epstein-Barr virus infection
    K17454  E2F1; transcription factor E2F1
   05165 Human papillomavirus infection
    K17454  E2F1; transcription factor E2F1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K17454  E2F1; transcription factor E2F1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K17454  E2F1; transcription factor E2F1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K17454  E2F1; transcription factor E2F1
Transcription factors [BR:ko03000]
Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix cell cycle-controlling factors, E2F
    K17454  E2F1; transcription factor E2F1

Genes

HSA:	1869(E2F1)

PTR:	107969994(E2F1)

PPS:	100983073(E2F1)

GGO:	101137595(E2F1)

PON:	100435851(E2F1)

PPYG:

129021690(E2F1)

NLE:	100601097(E2F1)

HMH:	116461337(E2F1)

SSYN:

129474784(E2F1)

MCC:	714126(E2F1)

MCF:	102146018(E2F1)

MTHB:

126964352

MNI:	105496223(E2F1)

CSAB:

103248605(E2F1)

CATY:

105582282(E2F1)

PANU:

101000533(E2F1)

TGE:	112632890(E2F1)

MLEU:

105528432(E2F1)

RRO:	104660298(E2F1)

RBB:	108533038(E2F1)

TFN:	117068658(E2F1)

PTEH:

111548151(E2F1)

CANG:

105525035(E2F1)

CJC:	100414261(E2F1)

SBQ:	101029045(E2F1)

CIMI:

108292968(E2F1)

ANAN:

105719040(E2F1)

CSYR:

103253965(E2F1)

MMUR:

105866012(E2F1)

LCAT:

123622430(E2F1)

ERUF:

138400878(E2F1)

PCOQ:

105804948(E2F1)

OGA:	100957114(E2F1)

MMU:	13555(E2f1)

MCAL:

110289983(E2f1)

MPAH:

110318578(E2f1)

RNO:	399489(E2f1)

MCOC:

116091213(E2f1)

ANU:	117702649(E2f1)

ASYL:

127686109(E2f1)

MUN:	110554547(E2f1)

CGE:	100758556(E2f1)

MAUA:

101831709(E2f1)

PROB:

127228116(E2f1)

PLEU:

114706553(E2f1)

PMAV:

102910616(E2f1)

MORG:

121460216(E2f1)

MFOT:

126506895

AAMP:

119815142(E2f1)

CNL:	130881476(E2f1)

NGI:	103751571(E2f1)

HGL:	101717980(E2f1)

CPOC:

100729531(E2f1)

CCAN:

109690765(E2f1)

DORD:

105981580(E2f1)

DSP:	122120305(E2f1)

DMER:

138817322(E2f1)

PLOP:

125352360(E2f1)

NCAR:

124977154

MMMA:

107140105(E2f1)

ITI:	101961922(E2f1)

OCU:	100356957 127489175

OPI:	101529862(E2F1)

OCZ:	121157404(E2F1)

TUP:	102484832(E2F1)

GVR:	103586861(E2F1)

CFA:	485839(E2F1)

CLUD:

112673817(E2F1)

VVP:	112928157(E2F1)

VLG:	121478071(E2F1)

NPO:	129496621(E2F1)

AML:	117795744(E2F1)

UMR:	103674455(E2F1)

UAH:	113258272(E2F1)

UAR:	123798360(E2F1)

ELK:

111141556

LLV:

125109172

MPUF:

101681681(E2F1)

MNP:	132021842(E2F1)

MLK:	131807833(E2F1)

NVS:	122916153(E2F1)

ORO:	101366721(E2F1)

EJU:	114220748(E2F1)

ZCA:	113938493(E2F1)

MLX:	118011049(E2F1)

NSU:	110579642(E2F1)

LWW:	102743808(E2F1)

FCA:	101098454(E2F1)

PYU:	121012039(E2F1)

PCOO:

112869529(E2F1)

PBG:	122496358(E2F1)

PVIV:

125162284(E2F1)

LRUF:

124503500

LGF:	123580295(E2F1)

AJU:

106974609

PTG:	102963506(E2F1)

PPAD:

109272548(E2F1)

PUC:

125936106

PLEZ:

122215649(E2F1)

HHV:	120242807(E2F1)

BTA:	535369(E2F1)

BOM:	102274863(E2F1)

BIU:	109567683(E2F1)

BBUB:

123464883(E2F1)

BKE:	129625855(E2F1)

CHX:	102173018(E2F1)

OAS:	101117526(E2F1)

BTAX:

128058399(E2F1)

CSUM:

138091235(E2F1)

ODA:	120868702(E2F1)

CCAD:

122448331(E2F1)

MREE:

136157979(E2F1)

OVR:	110143013(E2F1)

MBEZ:

129562499(E2F1)

SSC:	100153846(E2F1)

CFR:	102517851(E2F1)

CBAI:

105073627(E2F1)

CDK:	105092697(E2F1)

VPC:	102527293(E2F1)

BACU:

103015828(E2F1)

BMUS:

118881917(E2F1)

LVE:	103070408(E2F1)

OOR:	101275686(E2F1)

LALB:

132505876(E2F1)

GMF:	115839325(E2F1)

DDP:	132438531(E2F1)

DLE:	111184273(E2F1)

PCAD:

102993481(E2F1)

PSIU:

116740076(E2F1)

PPHC:

136135110(E2F1)

NASI:

112398484(E2F1)

ECB:	100069192(E2F1)

EPZ:	103541516(E2F1)

EAI:	106823225(E2F1)

MYB:	102242618(E2F1)

MYD:	102759026(E2F1)

MMYO:

118663841(E2F1)

MLF:	102421766(E2F1)

MDT:	132239525(E2F1)

MYUM:

139013817(E2F1)

PKL:	118707945(E2F1)

EFUS:

103293372(E2F1)

MNA:	107527747(E2F1)

DRO:	112303722(E2F1)

SHON:

118985966(E2F1)

AJM:	119047797(E2F1)

PDIC:

114506109(E2F1)

PHAS:

123815031(E2F1)

MMF:	118618748(E2F1)

PPAM:

129070474(E2F1)

HAI:	109377242(E2F1)

RFQ:	117016274(E2F1)

PALE:

102895276(E2F1)

PGIG:

120603555(E2F1)

PVP:	105304277(E2F1)

RAY:	107519491(E2F1)

MJV:	108401113(E2F1)

TOD:	119234016(E2F1)

SARA:

101555654(E2F1)

SFUM:

130030292(E2F1)

SETR:

126017556(E2F1)

LAV:	100664468(E2F1)

TMU:

101357348

ETF:	101660509(E2F1)

MDO:	100032280(E2F1)

GAS:	123235468(E2F1)

SHR:	116421696(E2F1)

AFZ:

127550324

PCW:	110216806(E2F1)

TVP:	118843580(E2F1)

PBRV:

138153570(E2F1)

MLAO:

141505884(E2F1)

OAA:	100087014(E2F1)

TACU:

119937605(E2F1)

GGA:	396142(E2F1)

PCOC:

116235132(E2F1)

MGP:	100544202(E2F1)

CJO:	107322866(E2F1)

TPAI:

128081153(E2F1)

LMUT:

125701457(E2F1)

NMEL:

110408351(E2F1)

APLA:

101801576(E2F1)

AACU:

137865630(E2F1)

ACYG:

106047751(E2F1)

CATA:

118248968(E2F1)

AFUL:

116495793(E2F1)

TGU:	115497941(E2F1)

LSR:	110475930(E2F1)

SCAN:

103818778(E2F1)

PMOA:

120511294(E2F1)

PRUF:

121359607(E2F1)

ATRC:

139599381(E2F1)

GFR:	102032688(E2F1)

FAB:	101808436(E2F1)

OMA:	130261348(E2F1)

PHI:	102114020(E2F1)

CCAE:

111943945(E2F1)

CCW:	104687904(E2F1)

CBRC:

103616228(E2F1)

ACOE:

138120846(E2F1)

ETL:	114057267(E2F1)

ZLE:	135456202(E2F1)

SVG:	106853078(E2F1)

MMEA:

130581202(E2F1)

HRT:	120760111(E2F1)

SATI:

136368376(E2F1)

CFAI:

136298115(E2F1)

CCIC:

134051497(E2F1)

FPG:	101912302(E2F1)

FCH:	102052559(E2F1)

SHAB:

115615417(E2F1)

SURA:

141951639(E2F1)

TALA:

104368510(E2F1)

ACHC:

115339886(E2F1)

HLE:	104842025(E2F1)

AGEN:

126045907

HHAR:

128143173(E2F1)

BBUT:

142028693(E2F1)

GCL:

127023475

CSTI:

104555941(E2F1)

LDI:	104341983(E2F1)

MNB:	103773296(E2F1)

DPUB:

104302736(E2F1)

PPUS:

135188173(E2F1)

AVIT:

104278316(E2F1)

BRHI:

104500594(E2F1)

EGZ:	104124989(E2F1)

NNI:	104019977(E2F1)

PCAO:

104042773(E2F1)

PADL:

103912425(E2F1)

AFOR:

103902903(E2F1)

CBOR:

142089612(E2F1)

CBOY:

140659626(E2F1)

MAME:

142417087(E2F1)

CLV:	102096538(E2F1)

CNIC:

135994885(E2F1)

MUI:	104548447(E2F1)

PLET:

104627607(E2F1)

EHS:	104508594(E2F1)

CUCA:

104063255(E2F1)

GAME:

129214353(E2F1)

CPEA:

104389398(E2F1)

CVF:	104292699(E2F1)

RTD:	128916433(E2F1)

CRID:

134522403(E2F1)

LMIC:

141750146(E2F1)

NARQ:

141471179(E2F1)

AAM:	106496602(E2F1)

AROW:

112978310(E2F1)

NPD:	112950026(E2F1)

TGT:	104571117(E2F1)

DNE:	112992476(E2F1)

SCAM:

104147959(E2F1)

ASN:	102379028(E2F1)

AMJ:	102576551(E2F1)

CPOO:

109313227(E2F1)

GGN:	109294648(E2F1)

PSS:	102448890(E2F1)

CIZ:	142022104(E2F1)

CMY:	102941250(E2F1)

CCAY:

125622290(E2F1)

LKP:	140897360(E2F1)

NDS:	141997845(E2F1)

DCC:	119842163(E2F1)

CPIC:

101946215(E2F1)

TST:	117886072(E2F1)

CABI:

116832532(E2F1)

MRV:	120381158(E2F1)

ACS:	100562223(e2f1)

ASAO:

132773243(E2F1)

PVT:	110090563(E2F1)

SUND:

121928742(E2F1)

PBI:	103052541(E2F1)

PMUR:

107294015(E2F1)

CTIG:

120308527(E2F1)

TSR:	106550369(E2F1)

PGUT:

117663684(E2F1)

PCAE:

139315408(E2F1)

APRI:

131195280(E2F1)

PTEX:

113434456(E2F1)

NSS:	113421353(E2F1)

VKO:	123032002(E2F1)

PMUA:

114599500(E2F1)

PRAF:

128416319(E2F1)

ZVI:	118089236(E2F1)

HCG:	128325229(E2F1)

GJA:	107122240(E2F1)

STOW:

125433689(E2F1)

EMC:	129331311(E2F1)

XLA:	100036852(e2f1.L) 108702783(e2f1.S)

XTR:	100493924(e2f1)

NPR:	108786119(E2F1)

RTEM:

120918662(E2F1)

ACAT:

141113301(E2F1)

PADS:

140325692(E2F1)

BBUF:

121005108(E2F1)

BGAR:

122941880(E2F1)

DTC:	141059130(E2F1)

MUO:	115476036(E2F1)

GSH:	117345534(E2F1)

DRE:	101885420(e2f1)

SRX:	107751961 107752207

SANH:

107653203 107694410

SGH:	107550152 107571003

CCAR:

109098512 109106942

CAUA:

113040866 113041391 113041620 113065425 113065815

CGIB:

127944596 128011973

PTET:

122332882(e2f1)

LROH:

127154346(e2f1)

GRF:	141291306(e2f1) 141291315

OMC:	131532597(e2f1)

PPRM:

120481010(e2f1)

RKG:	130083758(e2f1)

MAMB:

125260481(e2f1)

CIDE:

127505453 127505454

CERY:

137009348(e2f1)

MASI:

127418794 127419645

TROS:

130572030(e2f1)

TDW:	130409351(e2f1)

MANU:

129430874(e2f1)

PDAB:

135765023(e2f1)

IPU:

108275488

IFU:	128619837(e2f1)

PHYP:

113530396(e2f1)

SMEO:

124398910(e2f1)

TFD:	113655298(e2f1)

TVC:	132862625(e2f1)

CGAR:

128509974(e2f1)

NGRA:

132896713(e2f1)

TRN:	134333817(e2f1)

AMEX:

103022816(e2f1)

CMAO:

118822798(e2f1)

EEE:	113582354(e2f1)

CHAR:

105894245(e2f1)

TRU:	101061025(e2f1)

TFS:	130530203(e2f1)

TNG:	GSTEN00008908G001

LCO:	104929162(e2f1)

NCC:	104951480(e2f1)

TBEN:

117494423(e2f1)

CGOB:

115011372(e2f1)

PGEO:

117448986(e2f1)

GACU:

117532846(e2f1)

EMAC:

134869543(e2f1)

EFO:	125892153(e2f1)

PLEP:

121947243(e2f1)

SLUC:

116040864(e2f1)

ECRA:

117948041(e2f1)

ESP:	116692506(e2f1)

PFLV:

114559356(e2f1)

GAT:	120828798(e2f1)

PPUG:

119223406(e2f1)

AFB:	129100157(e2f1)

CLUM:

117733420(e2f1)

PSWI:

130200020(e2f1)

CANA:

137801013(e2f1)

CVE:	137889352(e2f1)

MSAM:

119906030(e2f1)

SCHU:

122883769(e2f1)

EARM:

139289495(e2f1)

CUD:	121518189(e2f1)

SPUL:

138590272(e2f1)

LMIX:

132989481(e2f1)

HTC:	141799977(e2f1)

ALAT:

119022881(e2f1)

ASTR:

137608391(e2f1)

PKLU:

139209192(e2f1)

MZE:	101472732(e2f1)

ONL:	100697698(e2f1)

OAU:	116311199(e2f1)

OLA:	101159192(e2f1)

OML:	112159014(e2f1)

CSAI:

133457490(e2f1)

XMA:	102233776(e2f1)

XCO:	114145865(e2f1)

XHE:	116723528(e2f1)

PRET:

103466857(e2f1)

PFOR:

103156104(e2f1)

PLAI:

106938542(e2f1)

PMEI:

106909249(e2f1)

GAF:	122824479(e2f1)

PPRL:

129371813(e2f1)

CVG:	107098766(e2f1)

CTUL:

119796401(e2f1)

GMU:	124868321(e2f1)

NFU:	107391318(e2f1)

KMR:	108233019(e2f1)

ALIM:

106522384(e2f1)

NWH:	119417168(e2f1)

AOCE:

111571778(e2f1)

EJA:	138193374(e2f1)

BFRE:

138618295(e2f1)

MCEP:

125021233(e2f1)

CSEM:

103384742(e2f1)

POV:

109630589

SSEN:

122777408(e2f1)

SSOE:

131469002(e2f1)

HHIP:

117765303(e2f1)

HSP:	118111424(e2f1)

PPLT:

128442900(e2f1)

SMAU:

118317237(e2f1)

LCF:

108882652

SDU:	111230697(e2f1)

SLAL:

111655259(e2f1)

XGL:	120803336(e2f1)

HCQ:	109511673(e2f1)

SSCV:

125989059(e2f1)

SBIA:

133490734(e2f1)

PEE:	133412580(e2f1)

PTAO:

133475392(e2f1)

BPEC:

110158087

ENY:	140363174(e2f1)

MALB:

109967120(e2f1)

BSPL:

114859244(e2f1)

SJO:	128357776(e2f1)

SSCO:

133988166(e2f1)

TTY:	137184118(e2f1)

GMH:	115551041(e2f1)

SASA:

106566901 106572360

STRU:

115165830 115168160

OTW:	112221983(e2f1) 112244985

OMY:	110492203(e2f1) 110532406

OGO:	124032072 124045852

ONE:	115102291 115132275

OKI:	109869539 109908098

OKE:	118359816(e2f1) 118360914

OMM:	135504296 135528193

OCLA:

139367674 139417304

SALP:

111966568 111976973

SNH:	120058860 120060707

SFON:

129829973 129860851(e2f1)

CCLU:

121538459 121545597

ELS:	105022766(e2f1)

OEP:	134019216(e2f1)

SFM:	108939107(e2f1)

PKI:	111842303(e2f1)

AANG:

118207213(e2f1)

AROT:

135234627(e2f1)

LOC:	102693522(e2f1)

PSPA:

121297708 121319268

ARUT:

117406596 117963853

PSEX:

120538014(e2f1)

LCM:	102358341(E2F1)

CMK:

CPLA:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

140735204(e2f1)

SDM:

118197693

» show all

Reference

PMID:1638634

Authors

Helin K, Lees JA, Vidal M, Dyson N, Harlow E, Fattaey A

Title

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F.

Journal

Cell 70:337-50 (1992)
DOI:10.1016/0092-8674(92)90107-N

Sequence

[hsa:1869]

Reference

PMID:17135249

Authors

Sylvestre Y, De Guire V, Querido E, Mukhopadhyay UK, Bourdeau V, Major F, Ferbeyre G, Chartrand P

Title

An E2F/miR-20a autoregulatory feedback loop.

Journal

J Biol Chem 282:2135-43 (2007)
DOI:10.1074/jbc.M608939200

Sequence

[hsa:1869]

LinkDB

DBGET integrated database retrieval system