KEGG ORTHOLOGY: K18463

ORTHOLOGY: K18463

Entry

K18463                      KO

Symbol

CCDC53

Name

WASH complex subunit CCDC53

Pathway

map04144

Endocytosis

map04212

Longevity regulating pathway - worm

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K18463  CCDC53; WASH complex subunit CCDC53
09150 Organismal Systems
  09149 Aging
   04212 Longevity regulating pathway - worm
    K18463  CCDC53; WASH complex subunit CCDC53
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K18463  CCDC53; WASH complex subunit CCDC53
Membrane trafficking [BR:ko04131]
Protein recycling
  Others
   WASH complex
    K18463  CCDC53; WASH complex subunit CCDC53

Genes

HSA:	51019(WASHC3)

PTR:	740826(WASHC3)

PPS:	100984779(WASHC3)

GGO:	101152474(WASHC3)

PON:	100442954(WASHC3)

PPYG:

129010134(WASHC3)

NLE:	100593788(WASHC3)

HMH:	116478041(WASHC3)

SSYN:

129461279(WASHC3)

MCC:	697824(WASHC3)

MCF:	102124959(WASHC3)

MTHB:

126931777

MNI:	105493823(WASHC3)

CSAB:

103238953(WASHC3)

CATY:

105573311(CCDC53)

PANU:

101008664(WASHC3)

TGE:	112635442(WASHC3)

MLEU:

105534473(CCDC53)

RRO:	104676453(WASHC3)

RBB:	108543136(CCDC53)

TFN:	117089535(WASHC3)

PTEH:

111523215(WASHC3)

CANG:

105506711(CCDC53)

CJC:	100393192(WASHC3)

SBQ:	101035471(CCDC53)

CIMI:

108294790(WASHC3)

ANAN:

105711492 105728710(WASHC3)

CSYR:

103258826(WASHC3)

MMUR:

105875564(WASHC3)

LCAT:

123639379(WASHC3)

PCOQ:

105815119(CCDC53)

OGA:	100952355(WASHC3)

MMU:	67282(Washc3)

MCAL:

110303331(Washc3)

MPAH:

110326621(Washc3)

RNO:	299707(Washc3)

MCOC:

116075922(Washc3)

ANU:	117696096(Washc3)

ASYL:

127670510(Washc3)

MUN:	110550292(Washc3)

CGE:	100771573(Washc3) 103161736

MAUA:

101824333(Washc3)

PROB:

127237926(Washc3)

PLEU:

114700642(Washc3)

MORG:

121460839(Washc3)

MFOT:

126503811

AAMP:

119803597(Washc3)

NGI:	103733729(Washc3)

HGL:	101709358(Washc3)

CPOC:

100723671(Washc3)

CCAN:

109700661(Washc3)

DORD:

105987923(Ccdc53)

DSP:	122119304(Washc3)

DMER:

138805989(Washc3)

PLOP:

125359471(Washc3)

NCAR:

124983319

MMMA:

107139966(Washc3)

ITI:	101970441(Washc3)

OCU:	100341085(WASHC3)

OPI:	101527399(WASHC3)

OCZ:	121159328(WASHC3)

TUP:	102488308(WASHC3)

GVR:	103604199(CCDC53)

CFA:	475444(WASHC3)

CLUD:

112654779(WASHC3) 112671927

VVP:	112930688(WASHC3)

VLG:	121481532(WASHC3) 121483441

NPO:	129517032(WASHC3)

AML:	100474273(WASHC3)

UMR:	103676499(WASHC3)

UAH:	113256084(WASHC3)

UAR:	123780949(WASHC3)

ELK:

111142189

LLV:	125086903 125106556 125107768

MPUF:

101678518(CCDC53)

MNP:	132019324(WASHC3)

MLK:	131839332(WASHC3)

NVS:	122892625(WASHC3)

ORO:	101385151(CCDC53)

EJU:	114223005(WASHC3)

ZCA:	113922828(WASHC3)

MLX:	117998819(WASHC3)

NSU:	110578050(WASHC3)

LWW:	102727181(WASHC3)

FCA:	101100491(WASHC3)

PYU:	121040530(WASHC3)

PCOO:

112863601(WASHC3)

PBG:	122472599(WASHC3)

PVIV:

125170484(WASHC3)

LRUF:

124501450

LGF:	123590767(WASHC3)

AJU:	106971902(WASHC3)

PTG:	102970430(WASHC3)

PPAD:

109265413(WASHC3)

PUC:

125919485

PLEZ:

122224996(WASHC3)

HHV:	120245440(WASHC3)

BTA:	613720(WASHC3)

BOM:	102270601(WASHC3)

BIU:	109559444(WASHC3)

BBUB:

102390414(WASHC3) 102396449

BBIS:

104998324(CCDC53)

CHX:	102175370(CCDC53)

OAS:	101109346(WASHC3)

BTAX:

128048501(WASHC3)

CSUM:

138078998(WASHC3)

ODA:	120858666(WASHC3)

CCAD:

122423484(WASHC3) 122454391

MREE:

136159159(WASHC3)

OVR:	110129531(WASHC3)

MBEZ:

129537186(WASHC3)

SSC:	102165500(WASHC3)

CFR:	102508135(WASHC3)

CBAI:

105075048(CCDC53)

CDK:	105097463(WASHC3)

VPC:	102529142(WASHC3)

BACU:

103017107(WASHC3)

BMUS:

118902354(WASHC3) 118904337

LVE:	103074096 103074279(CCDC53)

OOR:	101271424(WASHC3) 101282705 101287305

LALB:

132515578 132527964 132529142(WASHC3)

GMF:	115852939(WASHC3)

DDP:	132433993(WASHC3)

DLE:	111171732 111187906(WASHC3)

PCAD:

102990902 102991419(WASHC3)

PSIU:

116752068 116756962 116761058(WASHC3)

PPHC:

136131013(WASHC3)

NASI:

112391074(WASHC3)

ECB:	100053117(WASHC3)

EPZ:	103549355(WASHC3)

EAI:	106827277(WASHC3)

MYB:	102254242(WASHC3)

MYD:	102754447(WASHC3)

MMYO:

118650901(WASHC3) 118651141 118666123

MLF:	102426348(WASHC3)

MDT:	132227112(WASHC3) 132228021

MYUM:

139007458(WASHC3)

PKL:	118729800(WASHC3)

EFUS:

103288957(WASHC3)

MNA:	107545148(CCDC53)

DRO:	112321900(WASHC3)

SHON:

119002271(WASHC3)

AJM:	119060289(WASHC3)

PDIC:

114514077(WASHC3)

PHAS:

123810662(WASHC3)

MMF:	118624013(WASHC3)

PPAM:

129071378(WASHC3)

HAI:	109387744(WASHC3)

RFQ:	117028086(WASHC3)

PALE:

102891779(WASHC3)

PGIG:

120614960(WASHC3)

PVP:	105310649(WASHC3)

RAY:	107501179(WASHC3)

MJV:	108410306(WASHC3)

TOD:	119247372(WASHC3)

SARA:

101540611(CCDC53)

SFUM:

130026659(WASHC3)

SETR:

126022304(WASHC3)

LAV:	100669444(WASHC3)

TMU:

101360917

ETF:	101645595(WASHC3)

DNM:	101444285(WASHC3)

MDO:	100014429(WASHC3)

GAS:	123248937(WASHC3)

SHR:	100917610(WASHC3)

AFZ:

127537801

PCW:	110205647(WASHC3)

TVP:	118844836 118850366(WASHC3)

PBRV:

138166745(WASHC3)

MLAO:

141515275(WASHC3)

OAA:	107547933(WASHC3)

TACU:

119936901(WASHC3)

GGA:	418094(WASHC3)

PCOC:

116226787(WASHC3)

MGP:	100544587 104911600

CJO:	107316264(WASHC3)

TPAI:

128073948(WASHC3)

LMUT:

125700305(WASHC3)

NMEL:

110393972(WASHC3)

APLA:

101793125(WASHC3)

ACYG:

106031033(WASHC3)

CATA:

118255282(WASHC3)

TGU:	100217627(WASHC3)

LSR:	110473667(WASHC3)

SCAN:

103819651(WASHC3)

PMOA:

120501636(WASHC3)

OTC:	121332908(WASHC3)

PRUF:

121363571(WASHC3)

ATRC:

139587800(WASHC3)

GFR:	102039592(WASHC3)

FAB:	101807301(WASHC3)

OMA:	130263399(WASHC3)

PHI:	102113510(CCDC53)

PMAJ:

107204675(WASHC3)

CCAE:

111936186(WASHC3)

CCW:	104696495(WASHC3)

CBRC:

103619568(CCDC53)

ACOE:

138104161(WASHC3)

ETL:	114056152(WASHC3)

ZAB:	102064451(WASHC3)

ZLE:	135460370(WASHC3)

ACHL:

103801352(CCDC53)

SVG:	106853664(CCDC53)

MMEA:

130584523 130586579

HRT:	120752313(WASHC3)

SATI:

136361781(WASHC3)

CCIC:

134043575(WASHC3)

FPG:	101911859(WASHC3)

FCH:	102048875(WASHC3)

CCRI:

104159427(CCDC53)

NNT:	104406688(CCDC53)

SHAB:

115604752(WASHC3)

ACUN:

113491481(WASHC3)

TALA:

104355657(WASHC3)

ACHC:

115352676(WASHC3)

HALD:

104322826(CCDC53)

HLE:	104830996(CCDC53)

AGEN:

126048033

HHAR:

128143144(WASHC3)

GCL:

127016374

CSTI:

104557794(CCDC53)

LDI:	104350214(CCDC53)

MNB:	103778624(CCDC53)

DPUB:

104296558(CCDC53)

PPUS:

135181933(WASHC3)

AVIT:

104269056(CCDC53)

BRHI:

104500294(CCDC53)

EGZ:	104135596(WASHC3)

NNI:	104013377(CCDC53)

PCRI:

104029945(CCDC53)

PCAO:

104040173(CCDC53)

PADL:

103924524(CCDC53)

AFOR:

103906500(WASHC3)

FGA:	104084002(CCDC53)

CBOR:

142085499(WASHC3)

GSTE:

104257155(CCDC53)

CBOY:

140656185(WASHC3)

MAME:

142410388(WASHC3)

CLV:	102091302(WASHC3)

CNIC:

135994053(WASHC3)

MUI:	104537104(CCDC53)

PGUU:

104457971(CCDC53)

PLET:

104615076(CCDC53)

EHS:	104510618(CCDC53)

CMAC:

104477784(CCDC53)

CUCA:

104058928(WASHC3)

TEO:

104377635

BREG:

104637343(CCDC53)

OHA:	104338294(CCDC53)

ACAR:

104519029(WASHC3)

CPEA:

104396083(CCDC53)

CVF:	104288615(CCDC53)

RTD:	128915191(WASHC3)

CRID:

134508697(WASHC3)

LMIC:

141741298(WASHC3)

AAM:	106488927(WASHC3)

AROW:

112974671(WASHC3)

NPD:	112946620(WASHC3)

TGT:	104578352(CCDC53)

DNE:	112995060(WASHC3)

SCAM:

104147346(CCDC53)

ASN:	102373970(WASHC3)

AMJ:	102558128(WASHC3)

CPOO:

109316553(WASHC3)

GGN:	109296132(WASHC3)

PSS:	102446330(WASHC3)

CIZ:	142020037(WASHC3)

CMY:	102933299(WASHC3)

CCAY:

125627379(WASHC3)

DCC:	119844100(WASHC3)

CPIC:

101938047(WASHC3)

TST:	117881481(WASHC3)

CABI:

116825725(WASHC3)

MRV:	120395853(WASHC3)

ACS:	100565829(washc3)

ASAO:

132775846(WASHC3)

PVT:	110084780(WASHC3)

SUND:

121931285(WASHC3)

PBI:	103063148(WASHC3)

PMUR:

107289476(WASHC3)

CTIG:

120305862(WASHC3)

TSR:	106542981(CCDC53)

PGUT:

117655351(WASHC3)

PCAE:

139319172(WASHC3)

APRI:

131202031(WASHC3)

PTEX:

113455193(WASHC3)

NSS:	113432815(WASHC3)

VKO:	123028884(WASHC3)

PMUA:

114605151(WASHC3)

PRAF:

128422217(WASHC3)

ZVI:	118090804(WASHC3)

HCG:	128327747(WASHC3)

GJA:	107120684(WASHC3)

STOW:

125435118(WASHC3)

EMC:	129335272(WASHC3)

XLA:	444750(washc3.L)

XTR:	549578(washc3)

NPR:	108787164(CCDC53)

RTEM:

120932132(WASHC3)

ACAT:

141132203(WASHC3)

BBUF:

120979141(WASHC3)

BGAR:

122925959(WASHC3)

DTC:	141088931(WASHC3)

PWL:	138287941(WASHC3)

MUO:	115477786(WASHC3)

GSH:	117363874(WASHC3)

DRE:	393142(washc3)

SRX:	107725528(ccdc53) 107744922

SANH:

107664856 107695862

SGH:	107590199 107596601

CCAR:

109052694 109068507(washc3)

CAUA:

113048162 113062729

CGIB:

127956685 127974847

PTET:

122342930(washc3)

LROH:

127164103(washc3)

GRF:	141333163(washc3)

OMC:	131538915(washc3)

PPRM:

120477030(washc3)

RKG:	130072249(washc3)

MAMB:

125244821(washc3)

CIDE:

127510477

CERY:

137024441(washc3)

MASI:

127434887 127436891

TROS:

130548041(washc3)

TDW:	130420354(washc3)

MANU:

129432201(washc3)

PDAB:

135749814(washc3)

IPU:	108274748(washc3)

IFU:	128618122(washc3)

PHYP:

113529945(washc3)

SMEO:

124392713(washc3)

TFD:	113653988(washc3)

TVC:	132856667(washc3)

CGAR:

128511910(washc3)

NGRA:

132881623(washc3)

TRN:	134322254(washc3)

AMEX:

103031856(washc3)

CMAO:

118812020(washc3)

EEE:	113588010(washc3)

CHAR:

105898358(washc3) 122131469

SPIL:

134062536(washc3)

ASAD:

121697171(washc3)

TRU:	101061891(washc3) 101062120

TFS:	130519167(washc3) 130519168

TNG:	GSTEN00021552G001

LCO:	109138269(washc3)

NCC:	104950105(ccdc53)

TBEN:

117484857(washc3)

CGOB:

115028540(washc3)

PGEO:

117468433(washc3)

GACU:

117559196(washc3)

EMAC:

134879055(washc3)

ELY:	117249332(washc3)

EFO:	125882638(washc3)

PLEP:

121961439(washc3)

SLUC:

116060115(washc3)

ECRA:

117938749(washc3)

ESP:	116673307(washc3)

PFLV:

114550382(washc3)

GAT:	120817681(washc3)

PPUG:

119210391(washc3)

AFB:	129112642(washc3)

CLUM:

117726199(washc3)

PSWI:

130200704(washc3)

CANA:

137791800(washc3)

CVE:	137877428(washc3)

MSAM:

119918160(washc3)

SCHU:

122871286(washc3)

CUD:	121505170(washc3)

SPUL:

138599541(washc3)

LMIX:

132956394(washc3)

HTC:	141810961(washc3)

ALAT:

119032658(washc3)

ASTR:

137589688(washc3)

MZE:	101475429(washc3)

ONL:	100693454(washc3)

OAU:	116334889(washc3)

OLA:	101173272(washc3)

OML:	112156187(washc3)

CSAI:

133424241(washc3)

XMA:	102234469(washc3)

XCO:	114160990(washc3)

XHE:	116736877(washc3)

PRET:

103459181(ccdc53)

PFOR:

103156926(ccdc53)

PLAI:

106949778(ccdc53)

PMEI:

106914471(ccdc53)

GAF:	122826195(washc3)

PPRL:

129375518(washc3)

CVG:	107105004(ccdc53)

CTUL:

119789327(washc3)

GMU:	124882814(washc3)

NFU:	107386120(ccdc53)

KMR:	108233179(washc3)

ALIM:

106514803(ccdc53)

NWH:	119428020(washc3)

AOCE:

111568562(washc3)

EJA:	138207521(washc3)

BFRE:

138631041(washc3)

MCEP:

124999965(washc3)

CSEM:

103382689(ccdc53)

POV:	109632786(washc3)

SSEN:

122767249(washc3)

SSOE:

131457303(washc3)

HHIP:

117757201(washc3)

HSP:	118101282(washc3)

PPLT:

128428880(washc3)

SMAU:

118288045(washc3)

LCF:	108890223(washc3)

SDU:	111224731(washc3)

SLAL:

111656502(washc3)

XGL:	120798268(washc3)

HCQ:	109523722(washc3)

SSCV:

125992136(washc3)

SBIA:

133493260(washc3)

PEE:	133397336(washc3)

PTAO:

133471770(washc3)

BPEC:

110161604(washc3)

ENY:	140367347(washc3)

MALB:

109959811(washc3)

BSPL:

114862764(washc3)

SJO:	128385324(washc3)

SSCO:

134004621(washc3)

TTY:	137176073(washc3)

GMH:	115532394(washc3)

SASA:

100195265(ccd53) 106576276

STRU:

115180022 115198938

OTW:	112214207 112217004(washc3)

OMY:	110490422 110500056

OGO:	123995604 124014197(washc3)

ONE:	115107063 115133035

OKI:	109896660(washc3) 109896672

OKE:	118366327 118392471

OMM:	135515841 135533690

OCLA:

139378556 139392630

SALP:

111951375 111951431 111982858

SNH:	120032217 120049943

SFON:

129838279 129865009(washc3)

CCLU:

121555314 123484744

ELS:	105030157(washc3)

OEP:	134037776(washc3)

SFM:	108931364(washc3)

PKI:	111846564(washc3)

AANG:

118218701 118231583

AROT:

135245532 135259184

CCOG:

133118932 133135583(washc3)

LOC:	102689730(ccdc53)

PSPA:

121318432(washc3)

ARUT:

117414803(washc3)

PSEX:

120534257(washc3)

LCM:	102357671(WASHC3)

CMK:	103179871(washc3)

RTP:

109930067

CPLA:

122559342(washc3)

HOC:	132824836(washc3)

SCAU:

119954836(washc3)

LERI:

129706323(washc3)

HAKA:

140734977(washc3)

PMRN:

116939996(WASHC3)

LRJ:	133350237(WASHC3)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115918018 115923701 590305

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

PFLL:

DME:	Dmel_CG7429(CCDC53)

DER:

6542295

DSE:

6611607

DSI:	Dsimw501_GD23500(Dsim_GD23500)

DYA:	Dyak_GE18730

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17916

DAZ:

108612001

DNV:

115563113

DHE:

111594957

DVI:	6627792(CCDC53)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135951204(CCDC53)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

109430884 109431638 115267491

ASUA:

134211123

CQU:	CpipJ_CPIJ003979

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108729747(CCDC53)

CCOA:

TCZ:

TSEP:

PBAR:

VEM:

COBS:

139104142(Ccdc53)

TLN:	139820918(Ccdc53)

HST:

DQU:

CFO:

FEX:

PMEC:

138940742(Ccdc53)

LHU:	105677689(CCDC53)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141529969(Ccdc53)

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:	124214891(CCDC53)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138133395(CCDC53)

DPA:

109535353

ESIM:

136416189(CCDC53)

EFOR:

136347916(CCDC53)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_202771

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137933002(CCDC53)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141432273(CCDC53)

CFEL:

113368382

CCRN:

123294502

API:	100168435(Ccdc53)

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106691448(CCDC53)

LDA:	142321748(CCDC53)

HVI:

124359128

MQU:

128993248

PHU:	Phum_PHUM549390

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138700310(CCDC53)

SGRE:

126278703

BROR:

134531017

IEL:

124157629

HAMR:

139700152(CCDC53)

FCD:

110853247

DPX:	DAPPUDRAFT_306616

DPZ:

124350031

AFRA:

136038758

PVM:	113821310(CCDC53)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123746272(CCDC53)

CQD:	128702711(CCDC53)

PTRU:

123510365

ESN:

126995842

MNZ:

135216116

MRJ:	136849220(CCDC53)

PORN:

139764344(CCDC53)

HAZT:

EAF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

GOE:

DFR:

CSCU:

CVS:	136972363(CCDC53)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_F59E12.10(ddl-1)

CBR:	CBG_02459(Cbr-ddl-1)

CRQ:	GCK72_006080

HRO:	HELRODRAFT_178638

LGI:	LOTGIDRAFT_183391

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:	106178160 106178161

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_51405

AQU:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

OBR:

OGL:

MFLO:

SITA:

SVS:

PAUA:

TANG:

ZOF:	121997584 122036910

MSIN:

ACAK:

ATR:

CJF:

OLU:	OSTLU_28270

OTA:	OT_ostta18g00600

BPG:	Bathy09g01470

MBR:	MONBRDRAFT_22818

SRE:	PTSG_09522

DFA:

DFA_06680

ACAN:

ACA1_158440

PTM:	GSPATT00015813001 GSPATT00027844001

AAF:	AURANDRAFT_20953

TVA:	4756109(TVAGG3_0506370)

GTT:	GUITHDRAFT_100316

» show all

Reference

PMID:19922875

Authors

Derivery E, Sousa C, Gautier JJ, Lombard B, Loew D, Gautreau A

Title

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

Journal

Dev Cell 17:712-23 (2009)
DOI:10.1016/j.devcel.2009.09.010

Sequence

[hsa:51019]

LinkDB

DBGET integrated database retrieval system