KEGG   ORTHOLOGY: K19644
Entry
K19644            Tight     KO                                     
Symbol
dfrA19, dfrA18
Name
dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Pathway
map00670  One carbon pool by folate
map00790  Folate biosynthesis
map01100  Metabolic pathways
Reaction
R00936  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00937  5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
R00939  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R00940  5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
R02235  dihydrofolate:NAD+ oxidoreductase
R02236  dihydrofolate:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    K19644  dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein)
   00670 One carbon pool by folate
    K19644  dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes
    K19644  dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3  dihydrofolate reductase
     K19644  dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance genes [BR:ko01504]
 Gene variants
  Trimethoprim resistance genes
   Dihydrofolate reductases
    K19644  dfrA19, dfrA18; dihydrofolate reductase (trimethoprim resistance protein)
Antimicrobial resistance: KEGG signatures [br01600.html]
 Signature KOs for antimicrobial resistance
  K19644
Other DBs
COG: COG0262
GO: 0004146
Genes
ECLY: LI62_012820
EAX: AAHF05_23660(dfrA19)
KOK: KONIH1_31170
CFD: CFNIH1_06135
CFQ: C2U38_21260(dfrA)
CFAR: CI104_25730
KIN: AB182_03125
PVJ: LMA04_21320(dfrA19)
EBC: C2U52_01420(dfrA)
AG: CAC81324(dfrA18)
Reference
PMID:9835490
  Authors
Tosini F, Visca P, Luzzi I, Dionisi AM, Pezzella C, Petrucca A, Carattoli A
  Title
Class 1 integron-borne multiple-antibiotic resistance carried by IncFI and IncL/M plasmids in Salmonella enterica serotype typhimurium.
  Journal
Antimicrob Agents Chemother 42:3053-8 (1998)
DOI:10.1128/AAC.42.12.3053
  Sequence
[ag:CAC81324]
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