KEGG   REACTION: R00939
Entry
R00939                      Reaction                               
Name
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Definition
Tetrahydrofolate + NADP+ <=> Dihydrofolate + NADPH + H+
Equation
C00101 + C00006 <=> C00415 + C00005 + C00080
Comment
NADH (see R00936)
Reaction class
RC00001  C00005_C00006
RC00109  C00101_C00415
Enzyme
1.5.1.3
Pathway
rn00670  One carbon pool by folate
rn00790  Folate biosynthesis
rn01100  Metabolic pathways
rn01240  Biosynthesis of cofactors
Module
M00126  Tetrahydrofolate biosynthesis, GTP => THF
M00840  Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF
M00841  Tetrahydrofolate biosynthesis, mediated by PTPS, GTP => THF
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.3
     R00939  Tetrahydrofolate + NADP+ <=> Dihydrofolate + NADPH + H+
Orthology
K00287  dihydrofolate reductase [EC:1.5.1.3]
K13938  dihydromonapterin reductase / dihydrofolate reductase [EC:1.5.1.50 1.5.1.3]
K13998  dihydrofolate reductase / thymidylate synthase [EC:1.5.1.3 2.1.1.45]
K18589  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18590  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K18591  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19643  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19644  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
K19645  dihydrofolate reductase (trimethoprim resistance protein) [EC:1.5.1.3]
Other DBs
RHEA: 15012
LinkDB

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