KEGG   ORTHOLOGY: K20561
Entry
K20561                      KO                                     
Symbol
CYP71BL2
Name
costunolide synthase [EC:1.14.14.150]
Pathway
map00909  Sesquiterpenoid and triterpenoid biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R09575  germacra-1(10),4,11(13)-trien-12-oate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (6alpha-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00909 Sesquiterpenoid and triterpenoid biosynthesis
    K20561  CYP71BL2; costunolide synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K20561  CYP71BL2; costunolide synthase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.150  costunolide synthase
     K20561  CYP71BL2; costunolide synthase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, plant type
  CYP71 family
   K20561  CYP71BL2; costunolide synthase
Other DBs
GO: 0102934
Genes
HAN: 110928784
ECAD: 122593991 122602228
LSV: 111885020 111890493 111890503
CCAV: 112526537
AG: AEG79727(CYP71BL3) AEI59780(CYP71BL2)
Reference
PMID:21515683 (CYP71BL2)
  Authors
Ikezawa N, Gopfert JC, Nguyen DT, Kim SU, O'Maille PE, Spring O, Ro DK
  Title
Lettuce costunolide synthase (CYP71BL2) and its homolog (CYP71BL1) from sunflower catalyze distinct regio- and stereoselective hydroxylations in sesquiterpene lactone metabolism.
  Journal
J Biol Chem 286:21601-11 (2011)
DOI:10.1074/jbc.M110.216804
  Sequence
[ag:AEI59780]
Reference
PMID:21858047 (CYP71BL3)
  Authors
Liu Q, Majdi M, Cankar K, Goedbloed M, Charnikhova T, Verstappen FW, de Vos RC, Beekwilder J, van der Krol S, Bouwmeester HJ
  Title
Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana.
  Journal
PLoS One 6:e23255 (2011)
DOI:10.1371/journal.pone.0023255
  Sequence
[ag:AEG79727]
LinkDB

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