KEGG   ORTHOLOGY: K22202
Entry
K22202                      KO                                     
Symbol
vpr
Name
HIV virus protein R
Pathway
map03230  Viral genome structure
map03240  Viral replication
map03250  Viral life cycle - HIV-1
map03260  Virion - Human immunodeficiency virus
map05170  Human immunodeficiency virus 1 infection
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06516  TNF signaling
nt06520  CGAS-STING signaling
nt06524  Apoptosis
  Element
N00440  HIV Vpu/Vif/Vpr to cGAS-STING signaling pathway
N00443  HIV Vpr/Nef/Tat to TNF-NFKB signaling pathway
N00447  HIV Vpr/Tat to TNF-JNK signaling pathway
N00453  HIV Vpr to intrinsic apoptotic pathway
N00454  HIV Vpr to intrinsic apoptotic pathway
N00456  HIV Vpr to CDC25-cell cycle G2M
N00457  HIV Vpr to cell cycle G2M
N00458  HIV Vpr to CDC25-cell cycle G2M
N00460  HIV Vpr to WEE1-cell cycle G2M
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22202  vpr; HIV virus protein R
   03240 Viral replication
    K22202  vpr; HIV virus protein R
   03250 Viral life cycle - HIV-1
    K22202  vpr; HIV virus protein R
   03260 Virion - Human immunodeficiency virus
    K22202  vpr; HIV virus protein R
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K22202  vpr; HIV virus protein R
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22202  vpr; HIV virus protein R
Viral proteins [BR:ko03200]
 ssRNA-RT viruses
  Human immunodeficiency virus
   K22202  vpr; HIV virus protein R
Other DBs
TC: 1.A.42.1
Genes
VG: 155807(vpr) 1724718(HIV2gp4) 956112(vpr)
Reference
PMID:8552585
  Authors
Piller SC, Ewart GD, Premkumar A, Cox GB, Gage PW
  Title
Vpr protein of human immunodeficiency virus type 1 forms cation-selective channels in planar lipid bilayers.
  Journal
Proc Natl Acad Sci U S A 93:111-5 (1996)
DOI:10.1073/pnas.93.1.111
  Sequence
[vg:155807]
Reference
PMID:27460548
  Authors
Yan Y, Huang F, Yuan T, Sun B, Yang R
  Title
HIV-1 Vpr increases HCV replication through VprBP in cell culture.
  Journal
Virus Res 223:153-60 (2016)
DOI:10.1016/j.virusres.2016.07.007
  Sequence
[vg:155807]
LinkDB

KEGG   ORTHOLOGY: K19258
Entry
K19258                      KO                                     
Symbol
tat
Name
HIV protein Tat
Pathway
map03230  Viral genome structure
map03250  Viral life cycle - HIV-1
map03260  Virion - Human immunodeficiency virus
map05170  Human immunodeficiency virus 1 infection
Network
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06516  TNF signaling
nt06517  TLR signaling
nt06524  Apoptosis
  Element
N00436  HIV Tat to TLR2/4-NFKB signaling pathway
N00443  HIV Vpr/Nef/Tat to TNF-NFKB signaling pathway
N00445  HIV Tat/Nef to TNF-p38 signaling pathway
N00447  HIV Vpr/Tat to TNF-JNK signaling pathway
N00448  HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00449  HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways
N00450  HIV Tat to intrinsic apoptotic pathway
N00451  HIV Tat to intrinsic apoptotic pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K19258  tat; HIV protein Tat
   03250 Viral life cycle - HIV-1
    K19258  tat; HIV protein Tat
   03260 Virion - Human immunodeficiency virus
    K19258  tat; HIV protein Tat
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K19258  tat; HIV protein Tat
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K19258  tat; HIV protein Tat
  09185 Viral protein families
   03200 Viral proteins
    K19258  tat; HIV protein Tat
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Microbial pathogens
   K19258  tat; HIV protein Tat
Viral proteins [BR:ko03200]
 ssRNA-RT viruses
  Human immunodeficiency virus
   K19258  tat; HIV protein Tat
Genes
VG: 155871(tat) 1724713(HIV2gp5) 956113(tat)
Reference
PMID:2990041
  Authors
Sodroski J, Patarca R, Rosen C, Wong-Staal F, Haseltine W
  Title
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.
  Journal
Science 229:74-7 (1985)
DOI:10.1126/science.2990041
  Sequence
[vg:155871]
Reference
PMID:19812265
  Authors
Romani B, Engelbrecht S, Glashoff RH
  Title
Functions of Tat: the versatile protein of human immunodeficiency virus type 1.
  Journal
J Gen Virol 91:1-12 (2010)
DOI:10.1099/vir.0.016303-0
LinkDB

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