KEGG   ORTHOLOGY: K22273
Entry
K22273            Tight     KO                                     
Symbol
NS3
Name
Hepatitis C virus serine protease / helicase NS3 [EC:3.4.21.98 3.6.1.15 5.6.2.6]
Pathway
map03230  Viral genome structure
map03240  Viral replication
map05160  Hepatitis C
map05203  Viral carcinogenesis
Network
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
nt06519  RLR signaling
nt06524  Apoptosis
  Element
N00271  HCV NS3/4A to RIG-I-like receptor signaling pathway
N00516  HCV NS3/4A to TLR3-IRF3 signaling pathway
N00517  HCV NS3/4A to TLR3-IRF3 signaling pathway
N00522  HCV NS3 to p21-cell cycle G1/S
N00526  HCV NS3 to crosstalk between extrinsic and intrinsic apoptotic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22273  NS3; Hepatitis C virus serine protease / helicase NS3
   03240 Viral replication
    K22273  NS3; Hepatitis C virus serine protease / helicase NS3
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K22273  NS3; Hepatitis C virus serine protease / helicase NS3
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22273  NS3; Hepatitis C virus serine protease / helicase NS3
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22273  NS3; Hepatitis C virus serine protease / helicase NS3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.98  hepacivirin
     K22273  NS3; Hepatitis C virus serine protease / helicase NS3
  3.6  Acting on acid anhydrides
   3.6.1  In phosphorus-containing anhydrides
    3.6.1.15  nucleoside-triphosphate phosphatase
     K22273  NS3; Hepatitis C virus serine protease / helicase NS3
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.2  Enzymes altering nucleic acid conformation
    5.6.2.6  RNA 3'-5' helicase
     K22273  NS3; Hepatitis C virus serine protease / helicase NS3
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus (Hepacivirus C)
   K22273  NS3; Hepatitis C virus serine protease / helicase NS3
Other DBs
GO: 0017111 0034458
Genes
VP: 951475-6(NS3)
Reference
PMID:8861916
  Authors
Love RA, Parge HE, Wickersham JA, Hostomsky Z, Habuka N, Moomaw EW, Adachi T, Hostomska Z
  Title
The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site.
  Journal
Cell 87:331-42 (1996)
DOI:10.1016/s0092-8674(00)81350-1
  Sequence
[vp:951475-6]
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
LinkDB

KEGG   ORTHOLOGY: K22274
Entry
K22274            Tight     KO                                     
Symbol
NS4A
Name
Hepatitis C virus non-structural protein 4A
Pathway
map03230  Viral genome structure
map03240  Viral replication
map05160  Hepatitis C
Network
nt06163  Hepatitis C virus (HCV)
nt06263  Hepatocellular carcinoma
nt06517  TLR signaling
nt06519  RLR signaling
  Element
N00271  HCV NS3/4A to RIG-I-like receptor signaling pathway
N00516  HCV NS3/4A to TLR3-IRF3 signaling pathway
N00517  HCV NS3/4A to TLR3-IRF3 signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09125 Information processing in viruses
   03230 Viral genome structure
    K22274  NS4A; Hepatitis C virus non-structural protein 4A
   03240 Viral replication
    K22274  NS4A; Hepatitis C virus non-structural protein 4A
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    K22274  NS4A; Hepatitis C virus non-structural protein 4A
 09180 Brite Hierarchies
  09185 Viral protein families
   03200 Viral proteins
    K22274  NS4A; Hepatitis C virus non-structural protein 4A
Viral proteins [BR:ko03200]
 +ssRNA viruses
  Hepatitis C virus (Hepacivirus C)
   K22274  NS4A; Hepatitis C virus non-structural protein 4A
Genes
VP: 951475-7(NS4A)
Reference
PMID:27928005
  Authors
Murayama A, Sugiyama N, Suzuki R, Moriyama M, Nakamura N, Mochizuki H, Wakita T, Kato T
  Title
Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus Production.
  Journal
J Virol 91:e02124-16 (2017)
DOI:10.1128/JVI.02124-16
  Sequence
[vp:951475-7]
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
LinkDB

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