ORTHOLOGY: K22466
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Entry
K22466 KO
Symbol
bzaF
Name
5-hydroxybenzimidazole synthase [EC:
4.1.99.23
]
Pathway
map00860
Porphyrin metabolism
Reaction
R11919
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole formate-lyase (5-hydroxybenzimidazole-forming)
Brite
KEGG Orthology (KO) [BR:
ko00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
K22466 bzaF; 5-hydroxybenzimidazole synthase
Enzymes [BR:
ko01000
]
4. Lyases
4.1 Carbon-carbon lyases
4.1.99 Other carbon-carbon lyases
4.1.99.23 5-hydroxybenzimidazole synthase
K22466 bzaF; 5-hydroxybenzimidazole synthase
BRITE hierarchy
Genes
GSU:
GSU3005
(thiC-2)
GSK:
KN400_2948
(thiC-2)
GME:
Gmet_0471
(thiC-2)
GPI:
GPICK_02630
GAO:
A2G06_14140
GBZ:
JZM60_08015
(thiC)
GEM:
GM21_3893
GEB:
GM18_4239
GEF:
FO488_14370
(thiC)
GEV:
GSVR_35330
(thiC)
GEC:
GEO60473_24280
(thiC_2)
GUR:
Gura_4183
GEO:
Geob_0543
(thiC-2)
GLO:
Glov_3677
TAMM:
GEAMG1_2108
(bzaF)
GBM:
Gbem_3809
(thiC-2)
GBN:
GEOBRER4_37000
(thiC)
GER:
KP004_18205
(thiC)
GSUB:
KP001_18030
(thiC)
GNT:
KP003_18225
(thiC)
GPL:
M1B72_01565
(thiC)
GHC:
L9S41_11450
(thiC)
PPD:
Ppro_2809
DEU:
DBW_3101
DVE:
DESUT3_08050
(thiC)
DEP:
AOP6_0798
(thiC)
DES:
DSOUD_0618
(thiC-2)
DSF:
UWK_02784
DAK:
DaAHT2_1596
DBK:
DGMP_09610
(thiC_1)
DDU:
GF1_11200
(thiC)
ECOM:
QTN59_15175
(thiC)
EAJ:
Q3M24_07245
(thiC)
ELAX:
KKHLCK_12900
(thiC)
EAQ:
LDFHOB_04700
(thiC)
DAL:
Dalk_0439
DAT:
HRM2_06760
(thiC)
DTO:
TOL2_C39750
(thiC2)
DWD:
DSCW_64740
(thiC)
DALK:
DSCA_61910
(thiC_2)
DVR:
Dvar_50470
DML:
Dmul_38190
(thiC2)
DLI:
dnl_04700
(thiC2)
DEK:
DSLASN_49290
(thiC_2)
DBR:
Deba_2032
DMP:
FAK_24670
(thiC)
TAV:
G4V39_09730
(thiC)
TMAI:
FVE67_00935
(thiC)
BROC:
IPI25_07410
(thiC)
BPIT:
BPIT_18350
DTP:
JZK55_23310
(thiC_2)
DHR:
LGS26_04000
(thiC)
» show all
Taxonomy
UniProt
Reference
PMID:
26237670
Authors
Mehta AP, Abdelwahed SH, Fenwick MK, Hazra AB, Taga ME, Zhang Y, Ealick SE, Begley TP
Title
Anaerobic 5-Hydroxybenzimidazole Formation from Aminoimidazole Ribotide: An Unanticipated Intersection of Thiamin and Vitamin B(1)(2) Biosynthesis.
Journal
J Am Chem Soc 137:10444-7 (2015)
DOI:
10.1021/jacs.5b03576
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integrated database retrieval system
