KEGG   ORTHOLOGY: K23668
Entry
K23668                      KO                                     
Symbol
FMQD
Name
fumiquinazoline A oxidase [EC:1.5.3.-]
Pathway
map00997  Biosynthesis of various other secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00997 Biosynthesis of various other secondary metabolites
    K23668  FMQD; fumiquinazoline A oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.3  With oxygen as acceptor
    1.5.3.-
     K23668  FMQD; fumiquinazoline A oxidase
Other DBs
RN: R12420
COG: COG0277
Genes
AFM: AFUA_6G12070
ACT: ACLA_017880
PDP: PDIP_39980
TMF: PMAA_015700
TRG: TRUGW13939_02411
Reference
PMID:21899262
  Authors
Ames BD, Haynes SW, Gao X, Evans BS, Kelleher NL, Tang Y, Walsh CT
  Title
Complexity generation in fungal peptidyl alkaloid biosynthesis: oxidation of fumiquinazoline A to the heptacyclic hemiaminal fumiquinazoline C by the flavoenzyme Af12070 from Aspergillus fumigatus.
  Journal
Biochemistry 50:8756-69 (2011)
DOI:10.1021/bi201302w
  Sequence
[afm:AFUA_6G12070]
Reference
PMID:24612080
  Authors
Lim FY, Ames B, Walsh CT, Keller NP
  Title
Co-ordination between BrlA regulation and secretion of the oxidoreductase FmqD directs selective accumulation of fumiquinazoline C to conidial tissues in Aspergillus fumigatus.
  Journal
Cell Microbiol 16:1267-83 (2014)
DOI:10.1111/cmi.12284
  Sequence
[afm:AFUA_6G12070]
LinkDB

KEGG   REACTION: R12420
Entry
R12420                      Reaction                               
Definition
Fumiquinazoline A + Oxygen <=> Fumiquinazoline C + Hydrogen peroxide
Equation
C22147 + C00007 <=> C22148 + C00027
Comment
fumiquinazoline A oxidase
Enzyme
1.5.3.-
Pathway
rn00997  Biosynthesis of various other secondary metabolites
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00901  Fumiquinazoline biosynthesis, tryptophan + alanine + anthranilate => fumiquinazoline
Orthology
K23668  fumiquinazoline A oxidase [EC:1.5.3.-]
LinkDB

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