KEGG   ORTHOLOGY: K27780
Entry
K27780                      KO                                     
Symbol
GO
Name
(19E)-geissoschizine oxidase [EC:1.14.19.80]
Pathway
map00901  Indole alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine
M00980  Strychnine biosynthesis, geissoschizine => strychnine
Reaction
R13329  
R13331  
R13342  
R13382  
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K27780  GO; (19E)-geissoschizine oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.19  With oxidation of a pair of donors resulting in the reduction of O2 to two molecules of water
    1.14.19.80  (19E)-geissoschizine oxidase
     K27780  GO; (19E)-geissoschizine oxidase
Genes
AG: AVM85916(GO) UQZ09621(GO) UQZ09630(GO)
Reference
PMID:35794473
  Authors
Hong B, Grzech D, Caputi L, Sonawane P, Lopez CER, Kamileen MO, Hernandez Lozada NJ, Grabe V, O'Connor SE
  Title
Biosynthesis of strychnine.
  Journal
Nature 607:617-622 (2022)
DOI:10.1038/s41586-022-04950-4
  Sequence
[ag:UQZ09621 UQZ09630]
Reference
PMID:29511102
  Authors
Qu Y, Easson MEAM, Simionescu R, Hajicek J, Thamm AMK, Salim V, De Luca V
  Title
Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine.
  Journal
Proc Natl Acad Sci U S A 115:3180-3185 (2018)
DOI:10.1073/pnas.1719979115
  Sequence
[ag:AVM85916]
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