KEGG   MODULE: M00374
Entry
M00374            Pathway   Module                                 
Name
Dicarboxylate-hydroxybutyrate cycle
Definition
(K00169+K00170+K00171+K00172) K01007 K01595 K00024 (K01677+K01678) (K00239+K00240-K00241-K18860) (K01902+K01903) (K15038,K15017) K14465 (K14467,K18861,K25774) K14534 K15016 K00626
Diagram
M00374  Dicarboxylate-hydroxybutyrate cycle
M00374

Class
Pathway modules; Energy metabolism; Carbon fixation
Pathway
map00720  Other carbon fixation pathways
map01200  Carbon metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Orthology
K00169,K00170,K00171,K00172  
pyruvate ferredoxin oxidoreductase [EC:1.2.7.1] [RN:R01196]
K01007  
pyruvate, water dikinase [EC:2.7.9.2] [RN:R00199]
K01595  
phosphoenolpyruvate carboxylase [EC:4.1.1.31] [RN:R00345]
K00024  
malate dehydrogenase [EC:1.1.1.37] [RN:R00342]
K01677,K01678  
fumarate hydratase [EC:4.2.1.2] [RN:R01082]
K00239,K00240,K00241,K18860  
succinate dehydrogenase / fumarate reductase [EC:1.3.5.1 1.3.5.4] [RN:R02164]
K01902,K01903  
succinyl-CoA synthetase [EC:6.2.1.5] [RN:R00405]
K15038,K15017  
succinyl-CoA reductase [EC:1.2.1.76] [RN:R09280]
K14465  
succinate semialdehyde reductase (NADPH) [EC:1.1.1.-] [RN:R09281]
K14467,K18861,K25774  
4-hydroxybutyrate---CoA ligase (AMP-forming) [EC:6.2.1.40] [RN:R09279]
K14534  
4-hydroxybutyryl-CoA dehydratase [EC:4.2.1.120] [RN:R10782]
K15016  
3-hydroxybutyryl-CoA dehydratase / 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.35] [RN:R03026 R01975]
K00626  
acetyl-CoA C-acetyltransferase [EC:2.3.1.9] [RN:R00238]
Complete
mse  Metallosphaera sedula DSM 5348
memj  Metallosphaera sedula MJ1HA
mhk  Metallosphaera hakonensis JCM 8857 = DSM 7519
mpru  Metallosphaera prunae
mten  Metallosphaera tengchongensis
pis  Pyrobaculum islandicum
pcl  Pyrobaculum calidifontis
pyr  Pyrobaculum ferrireducens
tne  Pyrobaculum neutrophilum
pyw  Pyrobaculum sp. WP30
ttn  Thermoproteus tenax
tuz  Thermoproteus uzoniensis
 » show all
Reaction
R01196  
R00199  
R00345  
R00342  
R01082  
R02164  
R00405  
R09280  
R09281  
R09279  
R10782  
R03026  
R01975  
R00238  
Compound
C00024  Acetyl-CoA
C00022  Pyruvate
C00074  Phosphoenolpyruvate
C00036  Oxaloacetate
C00149  (S)-Malate
C00122  Fumarate
C00042  Succinate
C00091  Succinyl-CoA
C00232  Succinate semialdehyde
C00989  4-Hydroxybutanoic acid
C11062  4-Hydroxybutyryl-CoA
C00877  Crotonoyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C00332  Acetoacetyl-CoA
Comment
Organism group: anaerobic hyperthermophilic archaea
Reference
PMID:18511565
  Authors
Huber H, Gallenberger M, Jahn U, Eylert E, Berg IA, Kockelkorn D, Eisenreich W, Fuchs G
  Title
A dicarboxylate/4-hydroxybutyrate autotrophic carbon assimilation cycle in the hyperthermophilic Archaeum Ignicoccus hospitalis.
  Journal
Proc Natl Acad Sci U S A 105:7851-6 (2008)
DOI:10.1073/pnas.0801043105
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