KEGG   MODULE: M00773
Entry
M00773            Pathway   Module                                 
Name
Tylosin biosynthesis, methylmalonyl-CoA + malonyl-CoA => tylactone => tylosin
Definition
K15988+K24555+K24556+K24557+K24558 K15989+K15990 K15992 K15991 K15993 K15994 K15995 K15996
Diagram
M00773

Orthology
K15988,K24555,K24556,K24557,K24558  
tylG; tylactone synthase [RN:R06448]
K15989  
tylMII; tylactone mycaminosyltransferase [EC:2.4.1.316] [RN:R06450]
K15990  
tylMIII; tylactone mycaminosyltransferase auxiliary protein [RN:R06450]
K15992  
tylI; cytochrome P450 TylI [RN:R06449]
K15991  
tylHI; 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase [EC:1.14.15.34] [RN:R10656]
K15993  
tylN; O-mycaminosyltylonolide 6-deoxyallosyltransferase [EC:2.4.1.317] [RN:R06451]
K15994  
tylCV; demethyllactenocin mycarosyltransferase [EC:2.4.1.318] [RN:R06452]
K15995  
tylE; demethylmacrocin O-methyltransferase [EC:2.1.1.102] [RN:R02859]
K15996  
tylF; macrocin O-methyltransferase [EC:2.1.1.101] [RN:R02858]
Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Macrolide biosynthesis
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R06448  
R06450  
R06449  
R10656  
R06451  
R06452  
R02859  
R02858  
Compound
C02557  Methylmalonyl-CoA
C00083  Malonyl-CoA
C12000  Tylactone
C12001  5-O-beta-D-Mycaminosyltylactone
C20760  20-Oxo-5-O-beta-mycaminosyltylactone
C12002  5-O-beta-D-Mycaminosyltylonolide
C12003  Demethyllactenocin
C02400  Demethylmacrocin
C00744  Macrocin
C01457  Tylosin
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