KEGG   MODULE: M00842
Entry
M00842            Pathway   Module                                 
Name
Tetrahydrobiopterin biosynthesis, GTP => BH4
Definition
K01495 K01737 K00072
Diagram
M00842

Orthology
K01495  
GTP cyclohydrolase IA [EC:3.5.4.16] [RN:R00428 R05046 R05048 R04639]
K01737  
6-pyruvoyltetrahydropterin synthase [EC:4.2.3.12] [RN:R04286]
K00072  
sepiapterin reductase [EC:1.1.1.153] [RN:R08208]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00790  Folate biosynthesis
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C00044  GTP
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C04895  7,8-Dihydroneopterin 3'-triphosphate
C03684  6-Pyruvoyltetrahydropterin
C00272  Tetrahydrobiopterin
Reference
  Authors
Thony B, Auerbach G, Blau N
  Title
Tetrahydrobiopterin biosynthesis, regeneration and functions.
  Journal
Biochem J 347 Pt 1:1-16 (2000)
DOI:10.1042/bj3470001
LinkDB

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