KEGG   MODULE: M00843
Entry
M00843            Pathway   Module                                 
Name
L-threo-Tetrahydrobiopterin biosynthesis, GTP => L-threo-BH4
Definition
K01495 K01737 K17745
Diagram
M00843

Orthology
K01495  
GTP cyclohydrolase IA [EC:3.5.4.16] [RN:R00428 R05046 R05048 R04639]
K01737  
6-pyruvoyltetrahydropterin [EC:4.2.3.12] [RN:R04286]
K17745  
sepiapterin reductase [EC:1.1.1.325] [RN:R09990]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00790  Folate biosynthesis
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
Reaction
Compound
C00044  GTP
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C04895  7,8-Dihydroneopterin 3'-triphosphate
C03684  6-Pyruvoyltetrahydropterin
C20264  L-threo-Tetrahydrobiopterin
Reference
  Authors
Cho SH, Na JU, Youn H, Hwang CS, Lee CH, Kang SO
  Title
Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum.
  Journal
Biochem J 340 ( Pt 2):497-503 (1999)
DOI:10.1042/bj3400497
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