KEGG   MODULE: M00894
Entry
M00894            Pathway   Module                                 
Name
Cannabidiol biosynthesis, malonyl-CoA => cannabidiol/dronabinol
Definition
K20503 K20508 K27602 K20502 K20501
Diagram
M00894  Cannabidiol biosynthesis, malonyl-CoA => cannabidiol/dronabinol
M00894

Class
Pathway modules; Biosynthesis of other secondary metabolites; Biosynthesis of phytochemical compounds
Pathway
map00999  Biosynthesis of various plant secondary metabolites
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Orthology
K20503  
OLS; 3,5,7-trioxododecanoyl-CoA synthase [EC:2.3.1.206] [RN:R10171]
K20508  
OAC; olivetolic acid cyclase [EC:4.4.1.26] [RN:R10278]
K27602  
PT4; geranyl-pyrophosphate---olivetolic acid geranyltransferase [EC:2.5.1.102] [RN:R10176]
K20502  
CBDAS; cannabidiolic acid synthase [EC:1.21.3.8] [RN:R10160]
K20501  
THCAS; tetrahydrocannabinolic acid synthase [EC:1.21.3.7] [RN:R12101]
Complete
csav  Cannabis sativa (hemp)
Reaction
R10171  
R10278  
R10176  
R10160  
R12103  
R12101  
R12102  
Compound
C00083  Malonyl-CoA
C20413  3,5,7-Trioxododecanoyl-CoA
C20417  2,4-Dihydroxy-6-pentylbenzoate
C20406  Cannabigerolate
C10784  Cannabidiolic acid
C07578  Cannabidiol
C21903  Delta9-Tetrahydrocannabinolate
C06972  Dronabinol
Reference
PMID:17544411
  Authors
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S
  Title
Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
  Journal
FEBS Lett 581:2929-34 (2007)
DOI:10.1016/j.febslet.2007.05.043
LinkDB

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