KEGG   NETWORK: N00023
Entry
N00023                      Network                                
Name
EGF-EGFR-PLCG-ERK signaling pathway
Definition
EGF -> EGFR -> PLCG -> IP3 -> (Ca2+,DAG) -> PKC -> RAF -> MEK -> ERK -> CCND1
  Expanded
1950 -> 1956 -> (5335,5336) -> C01245 -> (C00076,C00165) -> (5578,5579,5582) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595
Class
nt06266 Non-small cell lung cancer
nt06220 Calcium signaling (cancer)
Type
Reference
Pathway
hsa04020  Calcium signaling pathway
Gene
1950  EGF; epidermal growth factor
1956  EGFR; epidermal growth factor receptor
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
595  CCND1; cyclin D1
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
C00165  Diacylglycerol
Reference
PMID:16107508
  Authors
Heo JS, Lee YJ, Han HJ
  Title
EGF stimulates proliferation of mouse embryonic stem cells: involvement of Ca2+ influx and p44/42 MAPKs.
  Journal
Am J Physiol Cell Physiol 290:C123-33 (2006)
DOI:10.1152/ajpcell.00142.2005
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