| Entry |
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| Name |
Mutation-activated KRAS/NRAS to PI3K signaling pathway
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| Definition |
(KRAS*,NRAS*) -> PI3K -> PIP3 -> AKT -| BAD |
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| Expanded |
(3845v1,4893v1) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
| H00014 | Non-small cell lung cancer |
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| Gene |
| 3845 | KRAS; KRAS proto-oncogene, GTPase |
| 4893 | NRAS; NRAS proto-oncogene, GTPase |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 572 | BAD; BCL2 associated agonist of cell death |
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| Variant |
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Schubbert S, Shannon K, Bollag G |
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| Title |
Hyperactive Ras in developmental disorders and cancer. |
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| Journal |
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| Reference |
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| Authors |
Adjei AA. |
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| Title |
Blocking oncogenic Ras signaling for cancer therapy. |
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| Journal |
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| Reference |
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| Authors |
Janssen KP. |
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| Title |
Murine models of colorectal cancer: studying the role of oncogenic K-ras. |
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| Journal |
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| Reference |
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| Authors |
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L. |
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| Title |
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia. |
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| Journal |
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| Reference |
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| Authors |
Miller AJ, Mihm MC Jr. |
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| Title |
Melanoma. |
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| Journal |
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| LinkDB |
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