| Entry |
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| Name |
Mutation-activated EGFR to PI3K signaling pathway
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| Definition |
EGFR* -> PI3K -> PIP3 -> AKT -| BAD |
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| Expanded |
(1956v2,1956v3) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572 |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
| H00014 | Non-small cell lung cancer |
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| Gene |
| 1956 | EGFR; epidermal growth factor receptor |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 572 | BAD; BCL2 associated agonist of cell death |
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| Variant |
1956v2 (EGFR*) EGFR mutation in non-small cell lung cancer
1956v3 (EGFR*) First generation TKI-resistant EGFR mutation
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Osada H, Takahashi T. |
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| Title |
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. |
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| Journal |
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| Reference |
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| Authors |
Hirsch FR, Scagliotti GV, Langer CJ, Varella-Garcia M, Franklin WA. |
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| Title |
Epidermal growth factor family of receptors in preneoplasia and lung cancer: perspectives for targeted therapies. |
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| Journal |
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| LinkDB |
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