Entry Name Mutation-inactivated APC to Wnt signaling pathway
Definition (GSK3B+AXIN) // APC* // CTNNB1 -> TCF/LEF => (BIRC5,MYC,CCND1)
Expanded (2932+(8312,8313)) // 324v1 // 1499 -> (6932,83439,6934,51176) => (332,4609,595)
Class Type Variant
Pathway Disease Gene 2932 GSK3B; glycogen synthase kinase 3 beta
324 APC; APC, WNT signaling pathway regulator
1499 CTNNB1; catenin beta 1
6932 TCF7; transcription factor 7
83439 TCF7L1; transcription factor 7 like 1
6934 TCF7L2; transcription factor 7 like 2
51176 LEF1; lymphoid enhancer binding factor 1
332 BIRC5; baculoviral IAP repeat containing 5
4609 MYC; MYC proto-oncogene, bHLH transcription factor
Variant 324v1 (APC*) APC mutation
Reference Authors Duchartre Y, Kim YM, Kahn M
Title The Wnt signaling pathway in cancer.
Journal Reference Authors Takebe N, Harris PJ, Warren RQ, Ivy SP
Title Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways.
Journal Reference Authors Takayama T, Miyanishi K, Hayashi T, Sato Y, Niitsu Y.
Title Colorectal cancer: genetics of development and metastasis.
Journal Reference Authors Polakis P.
Title The adenomatous polyposis coli (APC) tumor suppressor.
Journal Reference Authors Behrens J.
Title The role of the Wnt signalling pathway in colorectal tumorigenesis.
Journal Reference Authors Giles RH, van Es JH, Clevers H
Title Caught up in a Wnt storm: Wnt signaling in cancer.
Journal Reference Authors Li X, Wu WK, Xing R, Wong SH, Liu Y, Fang X, Zhang Y, Wang M, Wang J, Li L, Zhou Y, Tang S, Peng S, Qiu K, Chen L, Chen K, Yang H, Zhang W, Chan MT, Lu Y, Sung JJ, Yu J
Title Distinct Subtypes of Gastric Cancer Defined by Molecular Characterization Include Novel Mutational Signatures with Prognostic Capability.
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