| Entry |
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| Name |
Amplified MYC to p15-cell cycle G1/S
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| Definition |
(MYC*+MAX) -| ZBTB17 => CDKN2B -| (CCND+CDK4/6) -> RB1 // E2F |
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| Expanded |
(4609v1+4149) -| 7709 => 1030 -| ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871) |
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| Class |
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| Type |
Variant
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| Pathway |
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| Disease |
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| Gene |
| 4609 | MYC; MYC proto-oncogene, bHLH transcription factor |
| 4149 | MAX; MYC associated factor X |
| 7709 | ZBTB17; zinc finger and BTB domain containing 17 |
| 1030 | CDKN2B; cyclin dependent kinase inhibitor 2B |
| 1019 | CDK4; cyclin dependent kinase 4 |
| 1021 | CDK6; cyclin dependent kinase 6 |
| 5925 | RB1; RB transcriptional corepressor 1 |
| 1869 | E2F1; E2F transcription factor 1 |
| 1870 | E2F2; E2F transcription factor 2 |
| 1871 | E2F3; E2F transcription factor 3 |
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| Variant |
4609v1 (MYC*) MYC amplification
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| Reference |
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| Authors |
Osada H, Takahashi T. |
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| Title |
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer. |
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| Journal |
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| Reference |
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| Authors |
Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Moroy T, Bartek J, Massague J, Hanel F, Eilers M |
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| Title |
Repression of p15INK4b expression by Myc through association with Miz-1. |
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| Journal |
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| Reference |
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| Authors |
Adhikary S, Eilers M. |
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| Title |
Transcriptional regulation and transformation by Myc proteins. |
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| Journal |
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| Reference |
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| Authors |
Zajac-Kaye M |
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| Title |
Myc oncogene: a key component in cell cycle regulation and its implication for lung cancer. |
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| Journal |
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| LinkDB |
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