KEGG   NETWORK: N00238
Entry
N00238                      Network                                
Name
IGF1R-overexpression to PI3K signaling pathway
Definition
IGF2 -> IGF1R* -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
3481 -> 3480v1 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06263 Hepatocellular carcinoma
nt06214 PI3K signaling (cancer)
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
Disease
H00048  Hepatocellular carcinoma
Gene
3481  IGF2; insulin like growth factor 2
3480  IGF1R; insulin like growth factor 1 receptor
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Variant
3480v1 (IGF1R*)  IGF1R overexpression
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:20639898
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236
Reference
PMID:21829020
  Authors
Kudo M
  Title
Signaling pathway and molecular-targeted therapy for hepatocellular carcinoma.
  Journal
Dig Dis 29:289-302 (2011)
DOI:10.1159/000327562
Reference
PMID:19387255
  Authors
Minguez B, Tovar V, Chiang D, Villanueva A, Llovet JM
  Title
Pathogenesis of hepatocellular carcinoma and molecular therapies.
  Journal
Curr Opin Gastroenterol 25:186-94 (2009)
DOI:10.1097/MOG.0b013e32832962a1
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