KEGG   NETWORK: N00381
Entry
N00381                      Network                                
Name
HPV E6 to Notch signaling pathway
Definition
E6 -| MFNG -| NOTCH -> (NICD+RBPJ+MAML) => (HES1,HEY1)
  Expanded
K21807 -| 4242 -| (4851,4853,4854,4855) -> (C22528+(3516,11317)+(9794,84441,55534)) => (3280,23462)
Class
nt06511 NOTCH signaling
nt06166 Human papillomavirus (HPV)
Type
Pathogen
Pathway
hsa05165  Human papillomavirus infection
Disease
H00030  Cervical cancer
Gene
4242  MFNG; MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
4851  NOTCH1; notch 1
4853  NOTCH2; notch 2
4854  NOTCH3; notch 3
4855  NOTCH4; notch 4
3516  RBPJ; recombination signal binding protein for immunoglobulin kappa J region
11317  RBPJL; recombination signal binding protein for immunoglobulin kappa J region like
9794  MAML1; mastermind like transcriptional coactivator 1
84441  MAML2; mastermind like transcriptional coactivator 2
55534  MAML3; mastermind like transcriptional coactivator 3
3280  HES1; hes family bHLH transcription factor 1
23462  HEY1; hes related family bHLH transcription factor with YRPW motif 1
Perturbant
K21807 (E6)  E6; HPV protein E6
Metabolite
C22528  Notch intracellular domain
Reference
PMID:25752815
  Authors
Chen J
  Title
Signaling pathways in HPV-associated cancers and therapeutic implications.
  Journal
Rev Med Virol 25 Suppl 1:24-53 (2015)
DOI:10.1002/rmv.1823
Reference
PMID:15280477
  Authors
Veeraraghavalu K, Pett M, Kumar RV, Nair P, Rangarajan A, Stanley MA, Krishna S
  Title
Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation.
  Journal
J Virol 78:8687-700 (2004)
DOI:10.1128/JVI.78.16.8687-8700.2004
Reference
PMID:24109236
  Authors
Vliet-Gregg PA, Hamilton JR, Katzenellenbogen RA
  Title
NFX1-123 and human papillomavirus 16E6 increase Notch expression in keratinocytes.
  Journal
J Virol 87:13741-50 (2013)
DOI:10.1128/JVI.02582-13
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