NETWORK: N00413
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Entry
N00413 Network
Name
CXCR4-GNB/G-PLCB-PKC signaling pathway
Definition
CXCL12 -> CXCR4 -> GNB/G -> PLCB -> (Ca2+,
DAG) -> PKC -> PTK2B -> (PTK2+BCAR1+CRK+PXN)
Expanded
6387 -> 7852 -> (2782,
2783,
2784,
59345,
10681,
54331,
2785,
2786,
2787,
2788,
94235,
2790,
2791,
55970,
51764,
2792,
2793) -> (23236,
5330,
5331,
5332) -> (C00076,
C00165) -> (5578,
5579,
5582) -> 2185 -> (5747+9564+1398+5829)
Class
nt06167
Human cytomegalovirus (HCMV)
Type
Reference
Pathway
hsa04062
Chemokine signaling pathway
Gene
6387
CXCL12; C-X-C motif chemokine ligand 12
7852
CXCR4; C-X-C motif chemokine receptor 4
2782
GNB1; G protein subunit beta 1
2783
GNB2; G protein subunit beta 2
2784
GNB3; G protein subunit beta 3
59345
GNB4; G protein subunit beta 4
10681
GNB5; G protein subunit beta 5
54331
GNG2; G protein subunit gamma 2
2785
GNG3; G protein subunit gamma 3
2786
GNG4; G protein subunit gamma 4
2787
GNG5; G protein subunit gamma 5
2788
GNG7; G protein subunit gamma 7
94235
GNG8; G protein subunit gamma 8
2790
GNG10; G protein subunit gamma 10
2791
GNG11; G protein subunit gamma 11
55970
GNG12; G protein subunit gamma 12
51764
GNG13; G protein subunit gamma 13
2792
GNGT1; G protein subunit gamma transducin 1
2793
GNGT2; G protein subunit gamma transducin 2
23236
PLCB1; phospholipase C beta 1
5330
PLCB2; phospholipase C beta 2
5331
PLCB3; phospholipase C beta 3
5332
PLCB4; phospholipase C beta 4
5578
PRKCA; protein kinase C alpha
5579
PRKCB; protein kinase C beta
5582
PRKCG; protein kinase C gamma
2185
PTK2B; protein tyrosine kinase 2 beta
5747
PTK2; protein tyrosine kinase 2
9564
BCAR1; BCAR1, Cas family scaffold protein
1398
CRK; CRK proto-oncogene, adaptor protein
5829
PXN; paxillin
Metabolite
C00076
Calcium cation
C00165
Diacylglycerol
Reference
PMID:
17169327
Authors
Busillo JM, Benovic JL
Title
Regulation of CXCR4 signaling.
Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:
10.1016/j.bbamem.2006.11.002
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