| Entry |
|
|---|
| Name |
HSV gD to HVEM-NFKB signaling pathway
|
|---|
| Definition |
GD -> TNFRSF14 -> TRAF2/5 -> IKK -> NFKBIA -> NFKB => (BIRC2,BIRC3,NFKB1,RELA,CCL2) |
|---|
| Expanded |
K19264 -> 8764 -> (7186,7188) -> (1147+3551+8517) -> 4792 -> (4790+5970) => (329,330,4790,5970,6347) |
|---|
| Class |
|
|---|
| Type |
Pathogen
|
|---|
| Pathway |
| hsa05168 | Herpes simplex virus 1 infection |
| hsa04061 | Viral protein interaction with cytokine and cytokine receptor |
|
|---|
| Disease |
| H00365 | Herpes simplex virus infection |
|
|---|
| Gene |
| 8764 | TNFRSF14; TNF receptor superfamily member 14 |
| 7186 | TRAF2; TNF receptor associated factor 2 |
| 7188 | TRAF5; TNF receptor associated factor 5 |
| 1147 | CHUK; conserved helix-loop-helix ubiquitous kinase |
| 3551 | IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta |
| 8517 | IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma |
| 4792 | NFKBIA; NFKB inhibitor alpha |
| 4790 | NFKB1; nuclear factor kappa B subunit 1 |
| 5970 | RELA; RELA proto-oncogene, NF-kB subunit |
| 329 | BIRC2; baculoviral IAP repeat containing 2 |
| 330 | BIRC3; baculoviral IAP repeat containing 3 |
| 6347 | CCL2; C-C motif chemokine ligand 2 |
|
|---|
| Perturbant |
| K19264 (GD) | gD; Simplexvirus envelope glycoprotein D |
|
|---|
| Reference |
|
|---|
| Authors |
Edwards RG, Longnecker R |
|---|
| Title |
Herpesvirus Entry Mediator and Ocular Herpesvirus Infection: More than Meets the Eye. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
MacLeod IJ, Minson T |
|---|
| Title |
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry. |
|---|
| Journal |
|
|---|
| Reference |
|
|---|
| Authors |
Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffre-Cuculletto M, Venuti A, Grelli S, Bramanti P, Mastino A |
|---|
| Title |
Involvement of gD/HVEM interaction in NF-kB-dependent inhibition of apoptosis by HSV-1 gD. |
|---|
| Journal |
|
|---|
| LinkDB |
|
|---|
