KEGG   NETWORK: N00572
Entry
N00572                      Network                                
Name
HSV ICP34.5 to PKR-eIF2alpha signaling pathway
Definition
ICP34.5 == PPP1C -| EIF2S1
  Expanded
K19437 == (5499,5500,5501) -| 1965
Class
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
5499  PPP1CA; protein phosphatase 1 catalytic subunit alpha
5500  PPP1CB; protein phosphatase 1 catalytic subunit beta
5501  PPP1CC; protein phosphatase 1 catalytic subunit gamma
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
Perturbant
K19437 (ICP34.5)  RL1; HSV1 neurovirulence factor ICP34.5
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:9023344
  Authors
He B, Gross M, Roizman B
  Title
The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by  double-stranded RNA-activated protein kinase.
  Journal
Proc Natl Acad Sci U S A 94:843-8 (1997)
DOI:10.1073/pnas.94.3.843
Reference
PMID:12224508
  Authors
Leib DA
  Title
Counteraction of interferon-induced antiviral responses by herpes simplex viruses.
  Journal
Curr Top Microbiol Immunol 269:171-85 (2002)
DOI:10.1007/978-3-642-59421-2_11
Reference
PMID:22002165
  Authors
Walsh D, Mohr I
  Title
Viral subversion of the host protein synthesis machinery.
  Journal
Nat Rev Microbiol 9:860-75 (2011)
DOI:10.1038/nrmicro2655
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