KEGG   NETWORK: N00572
Entry
N00572                      Network                                
Name
HSV ICP34.5 to PKR-eIF2alpha signaling pathway
Definition
ICP34.5 -- PPP1C -| EIF2S1
  Expanded
K19437 -- (5499,5500,5501) -| 1965
Class
nt06138 PKR-eIF2alpha signaling (viruses)
nt06168 Herpes simplex virus 1 (HSV-1)
Type
Pathogen
Pathway
hsa05168  Herpes simplex virus 1 infection
Disease
H00365  Herpes simplex virus infection
Gene
5499  PPP1CA; protein phosphatase 1 catalytic subunit alpha
5500  PPP1CB; protein phosphatase 1 catalytic subunit beta
5501  PPP1CC; protein phosphatase 1 catalytic subunit gamma
1965  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
Perturbant
K19437 (ICP34.5)  RL1; HSV1 neurovirulence factor ICP34.5
Reference
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:9023344
  Authors
He B, Gross M, Roizman B
  Title
The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by  double-stranded RNA-activated protein kinase.
  Journal
Proc Natl Acad Sci U S A 94:843-8 (1997)
DOI:10.1073/pnas.94.3.843
Reference
  Authors
Leib DA
  Title
Counteraction of interferon-induced antiviral responses by herpes simplex viruses.
  Journal
Curr Top Microbiol Immunol 269:171-85 (2002)
DOI:10.1007/978-3-642-59421-2_11
Reference
  Authors
Walsh D, Mohr I
  Title
Viral subversion of the host protein synthesis machinery.
  Journal
Nat Rev Microbiol 9:860-75 (2011)
DOI:10.1038/nrmicro2655
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