| Entry |
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| Name |
IGF-IGF1R-PI3K signaling pathway
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| Definition |
IGF1 -> IGF1R -> PI3K -> PIP3 -> AKT -| (TSC1+TSC2) -| RHEB -> MTOR -| EIF4EBP1 |
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| Expanded |
3479 -> 3480 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (7248+7249) -| 6009 -> 2475 -| 1978 |
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| Class |
nt06168 Herpes simplex virus 1 (HSV-1)
nt06167 Human cytomegalovirus (HCMV)
nt06166 Human papillomavirus (HPV)
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| Type |
Reference
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| Pathway |
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| Gene |
| 3479 | IGF1; insulin like growth factor 1 |
| 3480 | IGF1R; insulin like growth factor 1 receptor |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
| 7248 | TSC1; TSC complex subunit 1 |
| 7249 | TSC2; TSC complex subunit 2 |
| 6009 | RHEB; Ras homolog, mTORC1 binding |
| 2475 | MTOR; mechanistic target of rapamycin kinase |
| 1978 | EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 |
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Laplante M, Sabatini DM |
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| Title |
mTOR signaling at a glance. |
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| Journal |
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| Reference |
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| Authors |
Kim SG, Buel GR, Blenis J |
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| Title |
Nutrient regulation of the mTOR complex 1 signaling pathway. |
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| Journal |
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| Reference |
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| Authors |
Meng D, Frank AR, Jewell JL |
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| Title |
mTOR signaling in stem and progenitor cells. |
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| Journal |
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| Reference |
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| Authors |
Lamming DW |
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| Title |
Diminished mTOR signaling: a common mode of action for endocrine longevity factors. |
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| Journal |
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| LinkDB |
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