Entry |
|
Name |
IGF-IGF1R-PI3K signaling pathway
|
Definition |
IGF1 -> IGF1R -> PI3K -> PIP3 -> AKT -| (TSC1+TSC2) -| RHEB -> MTOR -| EIF4EBP1 |
Expanded |
3479 -> 3480 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> (7248+7249) -| 6009 -> 2475 -| 1978 |
Class |
nt06168 Herpes simplex virus 1 (HSV-1)
nt06167 Human cytomegalovirus (HCMV)
nt06166 Human papillomavirus (HPV)
|
Type |
Reference
|
Pathway |
|
Gene |
3479 | IGF1; insulin like growth factor 1 |
3480 | IGF1R; insulin like growth factor 1 receptor |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
207 | AKT1; AKT serine/threonine kinase 1 |
208 | AKT2; AKT serine/threonine kinase 2 |
10000 | AKT3; AKT serine/threonine kinase 3 |
7248 | TSC1; TSC complex subunit 1 |
7249 | TSC2; TSC complex subunit 2 |
6009 | RHEB; Ras homolog, mTORC1 binding |
2475 | MTOR; mechanistic target of rapamycin kinase |
1978 | EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 |
|
Metabolite |
C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
|
Reference |
|
Authors |
Laplante M, Sabatini DM |
Title |
mTOR signaling at a glance. |
Journal |
|
Reference |
|
Authors |
Kim SG, Buel GR, Blenis J |
Title |
Nutrient regulation of the mTOR complex 1 signaling pathway. |
Journal |
|
Reference |
|
Authors |
Meng D, Frank AR, Jewell JL |
Title |
mTOR signaling in stem and progenitor cells. |
Journal |
|
Reference |
|
Authors |
Lamming DW |
Title |
Diminished mTOR signaling: a common mode of action for endocrine longevity factors. |
Journal |
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LinkDB |
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