Entry |
|
Name |
VGCC-Ca2+ -apoptotic pathway
|
Definition |
Ca2+(extracellular) -- VGCC -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7) |
Expanded |
C00076 -- (779,775,776,778,773,774,777,8913,8912,8911) -> C00076 -- 90550 -> C00076 -- (7416,7417,7419,291,292,293,83447) -> 54205 == 317 -> 842 -> (836,840) |
Class |
|
Type |
Reference
|
Pathway |
|
Gene |
779 | CACNA1S; calcium voltage-gated channel subunit alpha1 S |
775 | CACNA1C; calcium voltage-gated channel subunit alpha1 C |
776 | CACNA1D; calcium voltage-gated channel subunit alpha1 D |
778 | CACNA1F; calcium voltage-gated channel subunit alpha1 F |
773 | CACNA1A; calcium voltage-gated channel subunit alpha1 A |
774 | CACNA1B; calcium voltage-gated channel subunit alpha1 B |
777 | CACNA1E; calcium voltage-gated channel subunit alpha1 E |
8913 | CACNA1G; calcium voltage-gated channel subunit alpha1 G |
8912 | CACNA1H; calcium voltage-gated channel subunit alpha1 H |
8911 | CACNA1I; calcium voltage-gated channel subunit alpha1 I |
90550 | MCU; mitochondrial calcium uniporter |
7416 | VDAC1; voltage dependent anion channel 1 |
7417 | VDAC2; voltage dependent anion channel 2 |
7419 | VDAC3; voltage dependent anion channel 3 |
291 | SLC25A4; solute carrier family 25 member 4 |
292 | SLC25A5; solute carrier family 25 member 5 |
293 | SLC25A6; solute carrier family 25 member 6 |
83447 | SLC25A31; solute carrier family 25 member 31 |
54205 | CYCS; cytochrome c, somatic |
317 | APAF1; apoptotic peptidase activating factor 1 |
|
Metabolite |
|
Reference |
|
Authors |
Catterall WA |
Title |
Voltage-gated calcium channels. |
Journal |
|
Reference |
|
Authors |
Catterall WA, Lenaeus MJ, Gamal El-Din TM |
Title |
Structure and Pharmacology of Voltage-Gated Sodium and Calcium Channels. |
Journal |
|
Reference |
|
Authors |
Kondratskyi A, Kondratska K, Skryma R, Prevarskaya N |
Title |
Ion channels in the regulation of apoptosis. |
Journal |
|
Reference |
|
Authors |
Giorgi C, Danese A, Missiroli S, Patergnani S, Pinton P |
Title |
Calcium Dynamics as a Machine for Decoding Signals. |
Journal |
|
Reference |
|
Authors |
Bahar E, Kim H, Yoon H |
Title |
ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key Players. |
Journal |
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LinkDB |
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