Entry |
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Name |
mGluR5-Ca2+ -apoptotic pathway
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Definition |
Glutamate -> GRM5 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7) |
Expanded |
C00025 -> 2915 -> 2776 -> (23236,5330,5331,5332) -> C01245 -> (3708,3709,3710) -> C00076 -- 90550 -> C00076 -- (7416,7417,7419,291,292,293,83447) -> 54205 == 317 -> 842 -> (836,840) |
Class |
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Type |
Reference
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Pathway |
|
Gene |
2915 | GRM5; glutamate metabotropic receptor 5 |
2776 | GNAQ; G protein subunit alpha q |
23236 | PLCB1; phospholipase C beta 1 |
5330 | PLCB2; phospholipase C beta 2 |
5331 | PLCB3; phospholipase C beta 3 |
5332 | PLCB4; phospholipase C beta 4 |
3708 | ITPR1; inositol 1,4,5-trisphosphate receptor type 1 |
3709 | ITPR2; inositol 1,4,5-trisphosphate receptor type 2 |
3710 | ITPR3; inositol 1,4,5-trisphosphate receptor type 3 |
90550 | MCU; mitochondrial calcium uniporter |
7416 | VDAC1; voltage dependent anion channel 1 |
7417 | VDAC2; voltage dependent anion channel 2 |
7419 | VDAC3; voltage dependent anion channel 3 |
291 | SLC25A4; solute carrier family 25 member 4 |
292 | SLC25A5; solute carrier family 25 member 5 |
293 | SLC25A6; solute carrier family 25 member 6 |
83447 | SLC25A31; solute carrier family 25 member 31 |
54205 | CYCS; cytochrome c, somatic |
317 | APAF1; apoptotic peptidase activating factor 1 |
|
Metabolite |
C01245 | D-myo-Inositol 1,4,5-trisphosphate |
|
Reference |
|
Authors |
Berridge MJ, Lipp P, Bootman MD. |
Title |
The versatility and universality of calcium signalling. |
Journal |
|
Reference |
|
Authors |
Sushma, Mondal AC |
Title |
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease. |
Journal |
|
Reference |
|
Authors |
Penna E, Espino J, De Stefani D, Rizzuto R |
Title |
The MCU complex in cell death. |
Journal |
|
Reference |
|
Authors |
Giorgi C, Danese A, Missiroli S, Patergnani S, Pinton P |
Title |
Calcium Dynamics as a Machine for Decoding Signals. |
Journal |
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LinkDB |
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