Entry |
|
Name |
Mutation-caused aberrant SNCA to VGCC-Ca2+ -apoptotic pathway
|
Definition |
Ca2+(extracellular) -- SNCA* -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3 |
Expanded |
C00076 -- 6622v1 -> C00076 -- 90550 -> C00076 -- (7416,7417,7419,291,292,293,83447) -> 54205 == 317 -> 842 -> 836 |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
|
Gene |
6622 | SNCA; synuclein alpha |
90550 | MCU; mitochondrial calcium uniporter |
7416 | VDAC1; voltage dependent anion channel 1 |
7417 | VDAC2; voltage dependent anion channel 2 |
7419 | VDAC3; voltage dependent anion channel 3 |
291 | SLC25A4; solute carrier family 25 member 4 |
292 | SLC25A5; solute carrier family 25 member 5 |
293 | SLC25A6; solute carrier family 25 member 6 |
83447 | SLC25A31; solute carrier family 25 member 31 |
54205 | CYCS; cytochrome c, somatic |
317 | APAF1; apoptotic peptidase activating factor 1 |
|
Variant |
|
Metabolite |
|
Reference |
|
Authors |
Bezprozvanny I |
Title |
Calcium signaling and neurodegenerative diseases. |
Journal |
|
Reference |
|
Authors |
Zaichick SV, McGrath KM, Caraveo G |
Title |
The role of Ca(2+) signaling in Parkinson's disease. |
Journal |
|
Reference |
|
Authors |
Cali T, Ottolini D, Brini M |
Title |
Calcium signaling in Parkinson's disease. |
Journal |
|
LinkDB |
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