KEGG   NETWORK: N01065
Entry
N01065                      Network                                
Name
Mutation-activated RET to PI3K signaling pathway
Definition
RET* -> PI3K -> PIP3 -> AKT -> MTOR
  Expanded
5979v2 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475
Class
nt06214 PI3K signaling
Type
Variant
Disease
H00032  Thyroid cancer
Gene
5979  RET; ret proto-oncogene
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin kinase
Variant
5979v2 (RET*)  RET mutation
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Giunti S, Antonelli A, Amorosi A, Santarpia L
  Title
Cellular signaling pathway alterations and potential targeted therapies for medullary thyroid carcinoma.
  Journal
Int J Endocrinol 2013:803171 (2013)
DOI:10.1155/2013/803171
Reference
  Authors
Ceolin L, Duval MADS, Benini AF, Ferreira CV, Maia AL
  Title
Medullary thyroid carcinoma beyond surgery: advances, challenges, and perspectives.
  Journal
Endocr Relat Cancer 26:R499-R518 (2019)
DOI:10.1530/ERC-18-0574
Reference
  Authors
Arighi E, Borrello MG, Sariola H
  Title
RET tyrosine kinase signaling in development and cancer.
  Journal
Cytokine Growth Factor Rev 16:441-67 (2005)
DOI:10.1016/j.cytogfr.2005.05.010
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