| Entry |
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| Name |
RAC/CDC42-PAK-ERK signaling pathway
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| Definition |
(RAC1,CDC42) -> PAK1 -> RAF -> MEK -> ERK |
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| Expanded |
(5879,998) -> 5058 -> (369,673,5894) -> (5604,5605) -> (5594,5595) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 5879 | RAC1; Rac family small GTPase 1 |
| 998 | CDC42; cell division cycle 42 |
| 5058 | PAK1; p21 (RAC1) activated kinase 1 |
| 369 | ARAF; A-Raf proto-oncogene, serine/threonine kinase |
| 673 | BRAF; B-Raf proto-oncogene, serine/threonine kinase |
| 5894 | RAF1; Raf-1 proto-oncogene, serine/threonine kinase |
| 5604 | MAP2K1; mitogen-activated protein kinase kinase 1 |
| 5605 | MAP2K2; mitogen-activated protein kinase kinase 2 |
| 5594 | MAPK1; mitogen-activated protein kinase 1 |
| 5595 | MAPK3; mitogen-activated protein kinase 3 |
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| Reference |
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| Authors |
Shaul YD, Seger R |
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| Title |
The MEK/ERK cascade: from signaling specificity to diverse functions. |
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| Journal |
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| Reference |
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| Authors |
Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH |
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| Title |
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. |
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| Journal |
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| LinkDB |
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