KEGG   NETWORK: N01137
Entry
N01137                      Network                                
Name
PINK-Parkin-mediated autophagosome formation
Definition
PINK1 -> PRKN -> (CISD1,CISD2,FAF2,FKBP8,TOMM70,HK1) == (SQSTM1,OPTN,NDP52,TAX1BP1,NBR1) == LC3
  Expanded
65018 -> 5071 -> ((55847,493856,23197,23770,9868,3098) == (8878,10133,10241,8887,4077) == (84557,81631,643246,440738)
Class
nt06464 Amyotrophic lateral sclerosis
nt06466 Pathways of neurodegeneration
Type
Reference
Pathway
hsa04137  Mitophagy - animal
Gene
65018  PINK1; PTEN induced kinase 1
5071  PRKN; parkin RBR E3 ubiquitin protein ligase
55847  CISD1; CDGSH iron sulfur domain 1
493856  CISD2; CDGSH iron sulfur domain 2
23197  FAF2; Fas associated factor family member 2
23770  FKBP8; FKBP prolyl isomerase 8
9868  TOMM70; translocase of outer mitochondrial membrane 70
3098  HK1; hexokinase 1
8878  SQSTM1; sequestosome 1
10133  OPTN; optineurin
10241  CALCOCO2; calcium binding and coiled-coil domain 2
8887  TAX1BP1; Tax1 binding protein 1
4077  NBR1; NBR1 autophagy cargo receptor
84557  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha
81631  MAP1LC3B; microtubule associated protein 1 light chain 3 beta
643246  MAP1LC3B2; microtubule associated protein 1 light chain 3 beta 2
440738  MAP1LC3C; microtubule associated protein 1 light chain 3 gamma
Reference
PMID:30154567
  Authors
Palikaras K, Lionaki E, Tavernarakis N
  Title
Mechanisms of mitophagy in cellular homeostasis, physiology and pathology.
  Journal
Nat Cell Biol 20:1013-1022 (2018)
DOI:10.1038/s41556-018-0176-2
Reference
PMID:29370689
  Authors
Yoo SM, Jung YK
  Title
A Molecular Approach to Mitophagy and Mitochondrial Dynamics.
  Journal
Mol Cells 41:18-26 (2018)
DOI:10.14348/molcells.2018.2277
Reference
PMID:23503661
  Authors
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW
  Title
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
  Journal
Nature 496:372-6 (2013)
DOI:10.1038/nature12043
Reference
PMID:29656925
  Authors
Ordureau A, Paulo JA, Zhang W, Ahfeldt T, Zhang J, Cohn EF, Hou Z, Heo JM, Rubin LL, Sidhu SS, Gygi SP, Harper JW
  Title
Dynamics of PARKIN-Dependent Mitochondrial Ubiquitylation in Induced Neurons and Model Systems Revealed by Digital Snapshot Proteomics.
  Journal
Mol Cell 70:211-227.e8 (2018)
DOI:10.1016/j.molcel.2018.03.012
Reference
PMID:26268526
  Authors
Herhaus L, Dikic I
  Title
Expanding the ubiquitin code through post-translational modification.
  Journal
EMBO Rep 16:1071-83 (2015)
DOI:10.15252/embr.201540891
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