KEGG   Homo sapiens (human): 4077
Entry
4077              CDS       T01001                                 
Symbol
NBR1, 1A1-3B, IAI3B, M17S2, MIG19
Name
(RefSeq) NBR1 autophagy cargo receptor
  KO
K17987  next to BRCA1 gene 1 protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa04140  Autophagy - animal
Network
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06532  Autophagy
nt06536  Mitophagy
  Element
N01137  PINK-Parkin-mediated autophagosome formation
N01140  TBK1-mediated autophagosome formation
N01141  Mutation-inactivated TBK1 to TBK1-mediated autophagosome formation
N01716  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    4077 (NBR1)
   04137 Mitophagy - animal
    4077 (NBR1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4077 (NBR1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    4077 (NBR1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    4077 (NBR1)
  Pexophagy
   Other pexophagy associated proteins
    4077 (NBR1)
  Aggrephagy
   Cargo receptors
    4077 (NBR1)
  Xenophagy
    4077 (NBR1)
  Other autophagy associated proteins
   Midbophagy
    4077 (NBR1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Other mitophagy factors
    4077 (NBR1)
SSDB
Motif
Pfam: N_BRCA1_IG PB1 UBA_NBR1_C ZZ CENP-B_dimeris Sgf11
Other DBs
NCBI-GeneID: 4077
NCBI-ProteinID: NP_005890
OMIM: 166945
HGNC: 6746
Ensembl: ENSG00000188554
UniProt: Q14596
Structure
LinkDB
Position
17:43170409..43211688
AA seq 966 aa
MEPQVTLNVTFKNEIQSFLVSDPENTTWADIEAMVKVSFDLNTIQIKYLDEENEEVSINS
QGEYEEALKMAVKQGNQLQMQVHEGHHVVDEAPPPVVGAKRLAARAGKKPLAHYSSLVRV
LGSDMKTPEDPAVQSFPLVPCDTDQPQDKPPDWFTSYLETFREQVVNETVEKLEQKLHEK
LVLQNPSLGSCPSEVSMPTSEETLFLPENQFSWHIACNNCQRRIVGVRYQCSLCPSYNIC
EDCEAGPYGHDTNHVLLKLRRPVVGSSEPFCHSKYSTPRLPAALEQVRLQKQVDKNFLKA
EKQRLRAEKKQRKAEVKELKKQLKLHRKIHLWNSIHGLQSPKSPLGRPESLLQSNTLMLP
LQPCTSVMPMLSAAFVDENLPDGTHLQPGTKFIKHWRMKNTGNVKWSADTKLKFMWGNLT
LASTEKKDVLVPCLKAGHVGVVSVEFIAPALEGTYTSHWRLSHKGQQFGPRVWCSIIVDP
FPSEESPDNIEKGMISSSKTDDLTCQQEETFLLAKEERQLGEVTEQTEGTAACIPQKAKN
VASERELYIPSVDLLTAQDLLSFELLDINIVQELERVPHNTPVDVTPCMSPLPHDSPLIE
KPGLGQIEEENEGAGFKALPDSMVSVKRKAENIASVEEAEEDLSGTQFVCETVIRSLTLD
AAPDHNPPCRQKSLQMTFALPEGPLGNEKEEIIHIAEEEAVMEEEEDEEDEEEEDELKDE
VQSQSSASSEDYIIILPECFDTSRPLGDSMYSSALSQPGLERGAEGKPGVEAGQEPAEAG
ERLPGGENQPQEHSISDILTTSQTLETVPLIPEVVELPPSLPRSSPCVHHHGSPGVDLPV
TIPEVSSVPDQIRGEPRGSSGLVNSRQKSYDHSRHHHGSSIAGGLVKGALSVAASAYKAL
FAGPPVTAQPIISEDQTAALMAHLFEMGFCDRQLNLRLLKKHNYNILQVVTELLQLNNND
WYSQRY
NT seq 2901 nt   +upstreamnt  +downstreamnt
atggaaccacaggttactctaaatgtgacttttaaaaatgaaattcaaagctttctggtt
tctgatccagaaaatacaacttgggctgatatcgaagctatggtaaaagtttcatttgat
ctgaatactattcaaataaaatacctggatgaggaaaatgaagaggtatccatcaacagt
caaggagaatatgaagaagcgcttaagatggcagttaaacagggaaaccaactgcagatg
caagtccacgaagggcaccatgtcgttgatgaagccccacccccagttgtaggagcaaaa
cgactagctgccagggcagggaagaagccacttgcacattactcttcactggtgagagtc
ttgggatcagacatgaagaccccagaggatcctgcagtgcagtcgtttccacttgttcca
tgtgacacagaccagcctcaagacaagcccccagactggttcacaagctacctggagacg
ttcagagaacaagtggttaacgaaacggttgagaagcttgaacagaaattacatgaaaag
cttgtcctccagaacccatccttgggttcttgtccctcagaagtctcaatgcctacttca
gaagaaacattgtttttgccagaaaaccagttcagctggcatattgcttgcaacaactgc
caaagaaggattgttggtgtccgctaccagtgtagcctatgcccatcctacaatatctgt
gaagattgtgaagcagggccatatggccatgacactaaccacgtcctgctgaagttgcgg
agacctgttgtgggctcctctgaaccgttctgtcactcaaagtactctactcctcgtctt
cctgctgctctggaacaagtcaggctccagaaacaggttgataagaactttcttaaagca
gaaaagcaaaggttgcgagctgagaagaaacaacgtaaagcagaggtcaaggaacttaaa
aagcagcttaaactccataggaaaattcacctgtggaattcaatccatggactccagagc
cccaagtctcctttaggccgacctgagagcttgctccagtctaataccctgatgctccct
ttgcagccctgtacctccgttatgccaatgctcagtgcagcatttgtggatgagaatttg
cctgatgggactcaccttcagccaggaaccaagtttatcaaacactggaggatgaaaaat
acaggaaatgtaaagtggagtgcagacacaaagctcaagttcatgtggggaaacctgact
ttggcttccacagaaaagaaggatgttttggttccctgcctcaaggccggccatgtggga
gttgtatctgtggagttcattgccccagccttggagggaacgtatacttcccattggcgt
ctttctcacaaaggccagcaatttgggcctcgggtctggtgcagtatcatagtagatcct
ttcccctccgaagagagccctgataacattgaaaagggcatgatcagctcaagcaaaact
gatgatctcacctgccagcaagaggaaacttttcttctggctaaagaagaaagacagctt
ggtgaagtgactgagcagacagaagggacagcagcctgcatcccacagaaggcaaaaaat
gttgccagtgagagggagctctacatcccatctgtggatcttctgactgcccaggacctg
ctgtcctttgagctgttggatataaacattgttcaagagttggagagagtgccccacaac
acccctgtggatgtgactccctgcatgtctcctctgccacatgacagtcctttaatagag
aagccaggcttggggcagatagaggaagagaatgaaggggcaggatttaaagcacttcct
gattctatggtgtcagtaaagaggaaggctgagaacattgcttctgtggaggaagcagaa
gaagacctgagtgggacccagtttgtgtgtgagacagtaatccgatcccttaccttggat
gctgccccagaccacaaccctccttgcagacagaagtccttgcagatgacatttgccttg
cctgaaggaccacttggaaatgagaaggaggagattatccatatcgctgaggaagaagct
gtcatggaggaggaggaggatgaggaggatgaggaggaggaggatgagctcaaagatgaa
gttcaaagtcagtcctctgcttcctcagaggattacatcatcatcctgcctgagtgcttt
gataccagccgccccctgggggattctatgtacagctctgcgctctcacagccaggcctg
gagcgaggtgctgaaggcaagcctggggttgaggctgggcaggaaccagctgaggctggg
gaaagactccctggaggggagaaccagccacaggagcacagcataagtgacatcctcacg
acctcacagactctggaaacagtgcccctaatcccagaggtagtggagcttccaccgtca
ctgcccaggagctctccttgtgtacatcatcatggttccccaggagtggatttaccagtt
accataccagaagtttcttcagtccctgatcagatcagaggagagcccagaggctcatca
ggacttgtaaacagcagacagaagagctatgaccactcaaggcaccatcatgggagcagc
attgctggaggactggtgaagggggctttgtctgttgctgcctctgcatacaaggccctg
tttgctgggccaccagtcactgcacagccaataatttctgaagatcagacagcagccctg
atggcccatctctttgaaatgggattctgtgacaggcagctgaacctacggctgctgaag
aaacacaattacaatatcctgcaggttgtgacagaacttcttcagttaaacaacaacgac
tggtacagccaacgctattga

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