KEGG   Homo sapiens (human): 65018
Entry
65018             CDS       T01001                                 
Symbol
PINK1, BRPK, PARK6
Name
(RefSeq) PTEN induced kinase 1
  KO
K05688  PTEN induced putative kinase 1 [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04137  Mitophagy - animal
hsa05012  Parkinson disease
hsa05014  Amyotrophic lateral sclerosis
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06463  Parkinson disease
nt06464  Amyotrophic lateral sclerosis
nt06466  Pathways of neurodegeneration
nt06536  Mitophagy
  Element
N01043  Mutation-inactivated PINK1 to electron transfer in Complex I
N01048  Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01050  Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01052  PINK1-Parkin-mediated MFN2 degradation
N01053  Mutation-inactivated PINK1 to PINK1-Parkin-mediated MFN2 degradation
N01137  PINK-Parkin-mediated autophagosome formation
N01138  Mutation-inactivated OPTN to PINK-Parkin-mediated autophagosome formation
N01139  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01756  PINK-Parkin-independent ubiquitin-mediated mitophagy
N01757  PINK-Parkin-independent ubiquitin-mediated mitophagy, ubiquitin E3 ligase
Disease
H00057  Parkinson disease
H01600  Parkinsonian syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    65018 (PINK1)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    65018 (PINK1)
   05014 Amyotrophic lateral sclerosis
    65018 (PINK1)
   05022 Pathways of neurodegeneration - multiple diseases
    65018 (PINK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    65018 (PINK1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    65018 (PINK1)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    65018 (PINK1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     65018 (PINK1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: Other
  NKF2 family
   65018 (PINK1)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    65018 (PINK1)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    65018 (PINK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kinase-like APH
Other DBs
NCBI-GeneID: 65018
NCBI-ProteinID: NP_115785
OMIM: 608309
HGNC: 14581
Ensembl: ENSG00000158828
UniProt: Q9BXM7
Structure
LinkDB
Position
1:20633458..20651511
AA seq 581 aa
MAVRQALGRGLQLGRALLLRFTGKPGRAYGLGRPGPAAGCVRGERPGWAAGPGAEPRRVG
LGLPNRLRFFRQSVAGLAARLQRQFVVRAWGCAGPCGRAVFLAFGLGLGLIEEKQAESRR
AVSACQEIQAIFTQKSKPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQ
NLEVTKSTGLLPGRGPGTSAPGEGQERAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQE
LVPASRVALAGEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLP
SRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAH
RDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVST
ARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPP
DVRQLVRALLQREASKRPSARVAANVLHLSLWGEHILALKNLKLDKMVGWLLQQSAATLL
ANRLTEKCCVETKMKMLFLANLECETLCQAALLLCSWRAAL
NT seq 1746 nt   +upstreamnt  +downstreamnt
atggcggtgcgacaggcgctgggccgcggcctgcagctgggtcgagcgctgctgctgcgc
ttcacgggcaagcccggccgggcctacggcttggggcggccgggcccggcggcgggctgt
gtccgcggggagcgtccaggctgggccgcaggaccgggcgcggagcctcgcagggtcggg
ctcgggctccctaaccgtctccgcttcttccgccagtcggtggccgggctggcggcgcgg
ttgcagcggcagttcgtggtgcgggcctggggctgcgcgggcccttgcggccgggcagtc
tttctggccttcgggctagggctgggcctcatcgaggaaaaacaggcggagagccggcgg
gcggtctcggcctgtcaggagatccaggcaatttttacccagaaaagcaagccggggcct
gacccgttggacacgagacgcttgcagggctttcggctggaggagtatctgatagggcag
tccattggtaagggctgcagtgctgctgtgtatgaagccaccatgcctacattgccccag
aacctggaggtgacaaagagcaccgggttgcttccagggagaggcccaggtaccagtgca
ccaggagaagggcaggagcgagctccgggggcccctgccttccccttggccatcaagatg
atgtggaacatctcggcaggttcctccagcgaagccatcttgaacacaatgagccaggag
ctggtcccagcgagccgagtggccttggctggggagtatggagcagtcacttacagaaaa
tccaagagaggtcccaagcaactagcccctcaccccaacatcatccgggttctccgcgcc
ttcacctcttccgtgccgctgctgccaggggccctggtcgactaccctgatgtgctgccc
tcacgcctccaccctgaaggcctgggccatggccggacgctgttcctcgttatgaagaac
tatccctgtaccctgcgccagtacctttgtgtgaacacacccagcccccgcctcgccgcc
atgatgctgctgcagctgctggaaggcgtggaccatctggttcaacagggcatcgcgcac
agagacctgaaatccgacaacatccttgtggagctggacccagacggctgcccctggctg
gtgatcgcagattttggctgctgcctggctgatgagagcatcggcctgcagttgcccttc
agcagctggtacgtggatcggggcggaaacggctgtctgatggccccagaggtgtccacg
gcccgtcctggccccagggcagtgattgactacagcaaggctgatgcctgggcagtggga
gccatcgcctatgaaatcttcgggcttgtcaatcccttctacggccagggcaaggcccac
cttgaaagccgcagctaccaagaggctcagctacctgcactgcccgagtcagtgcctcca
gacgtgagacagttggtgagggcactgctccagcgagaggccagcaagagaccatctgcc
cgagtagccgcaaatgtgcttcatctaagcctctggggtgaacatattctagccctgaag
aatctgaagttagacaagatggttggctggctcctccaacaatcggccgccactttgttg
gccaacaggctcacagagaagtgttgtgtggaaacaaaaatgaagatgctctttctggct
aacctggagtgtgaaacgctctgccaggcagccctcctcctctgctcatggagggcagcc
ctgtga

DBGET integrated database retrieval system