Homo sapiens (human): 65018
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Entry
65018 CDS
T01001
Symbol
PINK1, BRPK, PARK6
Name
(RefSeq) PTEN induced kinase 1
KO
K05688
PTEN induced putative kinase 1 [EC:
2.7.11.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04137
Mitophagy - animal
hsa05012
Parkinson disease
hsa05014
Amyotrophic lateral sclerosis
hsa05022
Pathways of neurodegeneration - multiple diseases
Network
nt06463
Parkinson disease
nt06464
Amyotrophic lateral sclerosis
nt06466
Pathways of neurodegeneration
nt06536
Mitophagy
Element
N01043
Mutation-inactivated PINK1 to electron transfer in Complex I
N01048
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01050
Mutation-inactivated PINK1 to intrinsic apoptotic pathway
N01052
PINK1-Parkin-mediated MFN2 degradation
N01053
Mutation-inactivated PINK1 to PINK1-Parkin-mediated MFN2 degradation
N01137
PINK-Parkin-mediated autophagosome formation
N01138
Mutation-inactivated OPTN to PINK-Parkin-mediated autophagosome formation
N01139
Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation
N01756
PINK-Parkin-independent ubiquitin-mediated mitophagy
N01757
PINK-Parkin-independent ubiquitin-mediated mitophagy, ubiquitin E3 ligase
Disease
H00057
Parkinson disease
H01600
Parkinsonian syndrome
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09140 Cellular Processes
09141 Transport and catabolism
04137 Mitophagy - animal
65018 (PINK1)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
65018 (PINK1)
05014 Amyotrophic lateral sclerosis
65018 (PINK1)
05022 Pathways of neurodegeneration - multiple diseases
65018 (PINK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
65018 (PINK1)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
hsa04131
]
65018 (PINK1)
03029 Mitochondrial biogenesis [BR:
hsa03029
]
65018 (PINK1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
65018 (PINK1)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: Other
NKF2 family
65018 (PINK1)
Membrane trafficking [BR:
hsa04131
]
Autophagy
Mitophagy
PINK1-Parkin associated proteins
65018 (PINK1)
Mitochondrial biogenesis [BR:
hsa03029
]
Mitochondrial quality control factors
Mitophagy factors
Parkin-dependent mechanism factors
65018 (PINK1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
PK_Tyr_Ser-Thr
Kinase-like
APH
Motif
Other DBs
NCBI-GeneID:
65018
NCBI-ProteinID:
NP_115785
OMIM:
608309
HGNC:
14581
Ensembl:
ENSG00000158828
UniProt:
Q9BXM7
LinkDB
All DBs
Position
1:20633458..20651511
Genome browser
AA seq
581 aa
AA seq
DB search
MAVRQALGRGLQLGRALLLRFTGKPGRAYGLGRPGPAAGCVRGERPGWAAGPGAEPRRVG
LGLPNRLRFFRQSVAGLAARLQRQFVVRAWGCAGPCGRAVFLAFGLGLGLIEEKQAESRR
AVSACQEIQAIFTQKSKPGPDPLDTRRLQGFRLEEYLIGQSIGKGCSAAVYEATMPTLPQ
NLEVTKSTGLLPGRGPGTSAPGEGQERAPGAPAFPLAIKMMWNISAGSSSEAILNTMSQE
LVPASRVALAGEYGAVTYRKSKRGPKQLAPHPNIIRVLRAFTSSVPLLPGALVDYPDVLP
SRLHPEGLGHGRTLFLVMKNYPCTLRQYLCVNTPSPRLAAMMLLQLLEGVDHLVQQGIAH
RDLKSDNILVELDPDGCPWLVIADFGCCLADESIGLQLPFSSWYVDRGGNGCLMAPEVST
ARPGPRAVIDYSKADAWAVGAIAYEIFGLVNPFYGQGKAHLESRSYQEAQLPALPESVPP
DVRQLVRALLQREASKRPSARVAANVLHLSLWGEHILALKNLKLDKMVGWLLQQSAATLL
ANRLTEKCCVETKMKMLFLANLECETLCQAALLLCSWRAAL
NT seq
1746 nt
NT seq
+upstream
nt +downstream
nt
atggcggtgcgacaggcgctgggccgcggcctgcagctgggtcgagcgctgctgctgcgc
ttcacgggcaagcccggccgggcctacggcttggggcggccgggcccggcggcgggctgt
gtccgcggggagcgtccaggctgggccgcaggaccgggcgcggagcctcgcagggtcggg
ctcgggctccctaaccgtctccgcttcttccgccagtcggtggccgggctggcggcgcgg
ttgcagcggcagttcgtggtgcgggcctggggctgcgcgggcccttgcggccgggcagtc
tttctggccttcgggctagggctgggcctcatcgaggaaaaacaggcggagagccggcgg
gcggtctcggcctgtcaggagatccaggcaatttttacccagaaaagcaagccggggcct
gacccgttggacacgagacgcttgcagggctttcggctggaggagtatctgatagggcag
tccattggtaagggctgcagtgctgctgtgtatgaagccaccatgcctacattgccccag
aacctggaggtgacaaagagcaccgggttgcttccagggagaggcccaggtaccagtgca
ccaggagaagggcaggagcgagctccgggggcccctgccttccccttggccatcaagatg
atgtggaacatctcggcaggttcctccagcgaagccatcttgaacacaatgagccaggag
ctggtcccagcgagccgagtggccttggctggggagtatggagcagtcacttacagaaaa
tccaagagaggtcccaagcaactagcccctcaccccaacatcatccgggttctccgcgcc
ttcacctcttccgtgccgctgctgccaggggccctggtcgactaccctgatgtgctgccc
tcacgcctccaccctgaaggcctgggccatggccggacgctgttcctcgttatgaagaac
tatccctgtaccctgcgccagtacctttgtgtgaacacacccagcccccgcctcgccgcc
atgatgctgctgcagctgctggaaggcgtggaccatctggttcaacagggcatcgcgcac
agagacctgaaatccgacaacatccttgtggagctggacccagacggctgcccctggctg
gtgatcgcagattttggctgctgcctggctgatgagagcatcggcctgcagttgcccttc
agcagctggtacgtggatcggggcggaaacggctgtctgatggccccagaggtgtccacg
gcccgtcctggccccagggcagtgattgactacagcaaggctgatgcctgggcagtggga
gccatcgcctatgaaatcttcgggcttgtcaatcccttctacggccagggcaaggcccac
cttgaaagccgcagctaccaagaggctcagctacctgcactgcccgagtcagtgcctcca
gacgtgagacagttggtgagggcactgctccagcgagaggccagcaagagaccatctgcc
cgagtagccgcaaatgtgcttcatctaagcctctggggtgaacatattctagccctgaag
aatctgaagttagacaagatggttggctggctcctccaacaatcggccgccactttgttg
gccaacaggctcacagagaagtgttgtgtggaaacaaaaatgaagatgctctttctggct
aacctggagtgtgaaacgctctgccaggcagccctcctcctctgctcatggagggcagcc
ctgtga
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integrated database retrieval system
