| Entry |
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| Name |
NRG-ERBB4-PI3K signaling pathway
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| Definition |
NRG -> ERBB4 -> PI3K -> PIP3 -> AKT |
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| Expanded |
(3084,9542,10718,145957) -> 2066 -> (5290,5291,5293) -> C05981 -> (207,208,10000) |
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| Class |
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| Type |
Reference
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| Pathway |
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| Gene |
| 2066 | ERBB4; erb-b2 receptor tyrosine kinase 4 |
| 5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
| 5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
| 5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
| 207 | AKT1; AKT serine/threonine kinase 1 |
| 208 | AKT2; AKT serine/threonine kinase 2 |
| 10000 | AKT3; AKT serine/threonine kinase 3 |
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| Metabolite |
| C05981 | Phosphatidylinositol-3,4,5-trisphosphate |
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| Reference |
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| Authors |
Mei L, Nave KA |
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| Title |
Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases. |
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| Journal |
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| Reference |
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| Authors |
Liang X, Ding Y, Zhang Y, Chai YH, He J, Chiu SM, Gao F, Tse HF, Lian Q |
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| Title |
Activation of NRG1-ERBB4 signaling potentiates mesenchymal stem cell-mediated myocardial repairs following myocardial infarction. |
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| Journal |
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| Reference |
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| Authors |
Xie F, Padival M, Siegel RE |
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| Title |
Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture. |
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| Journal |
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| Reference |
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| Authors |
Vasti C, Hertig CM |
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| Title |
Neuregulin-1/erbB activities with focus on the susceptibility of the heart to anthracyclines. |
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| Journal |
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| LinkDB |
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